2010 Biopolymers Gordon Research Conference

2010年生物聚合物戈登研究会议

基本信息

批准号：
7903511
负责人：
DOROTHY BECKETT
金额：
$ 0.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-01 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7903511
关键词：
Amyloid Binding Biological Biological Process Biomedical Research Biopolymers Birth Cessation of life Communities Complex DNA Defect Disease Drug Delivery Systems Engineering Fostering Funding Applicant Gene Expression Goals Membrane Proteins Metabolism Minority Molecular Machines Nucleic Acids Play Problem Solving Property Proteins RNA Recording of previous events Research Role Schedule Science Scientist Signal Transduction Structure Students Suggestion System Techniques Therapeutic Agents Time Woman chemical property design human disease improved interest macromolecule meetings member programs protein structure public health relevance response symposium

Amyloid Binding Biological Biological Process Biomedical Research Biopolymers Birth Cessation of life Communities Complex DNA Defect Disease Drug Delivery Systems Engineering Fostering Funding Applicant Gene Expression Goals Membrane Proteins Metabolism Minority Molecular Machines Nucleic Acids Play Problem Solving Property Proteins RNA Recording of previous events Research Role Schedule Science Scientist Signal Transduction Structure Students Suggestion System Techniques Therapeutic Agents Time Woman chemical property design human disease improved interest macromolecule meetings member programs protein structure public health relevance response symposium

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项目摘要

DESCRIPTION (provided by applicant): Funds are requested for partial support of the 2010 Biopolymers Gordon Research Conference. This conference has a long and distinguished history of serving the segment of the scientific community that is focused on understanding fundamental physical-chemical properties of biopolymers (proteins, RNA, DNA), including their structures, folding, dynamics, stability, and interactions. The 2010 Biopolymers GRC is particularly interested in supporting the participation of minorities and women. The broad goals of the conference are to improve our understanding of the fundamental properties of biopolymers and the relationship of these properties to their biological function. The specific aims of this meeting are to assemble leaders in the biopolymers field with junior scientists, postdocs and students in a five-day conference to discuss current approaches to elucidating the structures, function and folding of biopolymers and their complexes. The significance of the proposal is the unique role that the Biopolymers Gordon Conference plays in fostering interdisciplinary interactions among scientists who apply a breadth of techniques to understanding a number of distinct systems. Regular interdisciplinary meetings of this type inevitably support advances in science by promoting integration of distinct approaches to solving problems. Most importantly, the format of the Gordon Research Conference, in which much time is allotted to informal and formal discussion, is ideal for fostering the interactions that are critical precursors to interdisciplinary science. Furthermore, the Biopolymers GRC, by advancing understanding of the fundamental properties of biological macromolecules will directly benefit biomedical research across diverse fields. In choosing topics and speakers for the 2010 meeting, input was sought from members of science community. The organizers have also incorporated suggestions offered in response to the 2008 program. In addition to a keynote session, the 2010 schedule includes the following regular sessions: 1. RNA structure, folding and dynamics 2. Molecular Machines Acting on Nucleic Acids; 3. Binding, Allostery and Dynamics; 4. Proteins from Birth to Death; 5. Biopolymers by Design; 6. Membrane Proteins: Structure, Folding and Function; 7. Folding and Unfolding, Order and Disorder, and 8. Amyloid (Death by Misfolding). PUBLIC HEALTH RELEVANCE: Biopolymers (proteins, RNA, DNA) are central to biological processes including signal transduction, metabolism and gene expression. Since defects in biopolymers are implicated in many human diseases, they are drug targets and are increasingly utilized as therapeutic agents themselves. The 2010 Biopolymers Gordon Research Conference will feature discussion of recent advances in understanding the structure, stability and dynamics of biopolymers as well as engineering of biopolymers for new function.

描述（由申请人提供）：要求资金部分支持2010年生物聚合物戈登研究会议。这次会议有一个悠久而杰出的历史，即为科学界的部分服务，该会议的重点是理解生物聚合物（蛋白质，RNA，RNA，DNA）的基本物理化学特性，包括其结构，折叠，动力学，稳定性和相互作用。 2010年的生物聚合物GRC对支持少数民族和妇女的参与特别感兴趣。会议的广泛目标是提高我们对生物聚合物基本特性以及这些特性与其生物学功能的关系的理解。这次会议的具体目的是在为期五天的会议上与初级科学家，博士后和学生一起在生物聚合物领域组成领导者，以讨论当前阐明生物聚合物及其复合物的结构，功能和折叠的方法。该提案的重要性是生物聚合物戈登会议在促进跨学科互动中发挥的独特作用，这些科学家在理解许多不同系统的科学家之间进行了跨学科的互动。这种类型的定期跨学科会议不可避免地通过促进解决问题的不同方法来支持科学的进步。最重要的是，戈登研究会议的格式在大量时间内分配给非正式和正式讨论，是培养互动是跨学科科学至关重要的相互作用的理想选择。此外，生物聚合物GRC通过促进对生物大分子的基本特性的理解将直接受益于各种领域的生物医学研究。在为2010年会议选择主题和发言人时，科学界成员寻求了意见。组织者还纳入了针对2008年计划提供的建议。除了主题演讲外，2010年的时间表还包括以下常规会话：1。RNA结构，折叠和动力学2。作用在核酸上的分子机器； 3。绑定，变构和动力学； 4。从出生到死亡的蛋白质； 5。设计的生物聚合物； 6。膜蛋白：结构，折叠和功能； 7。折叠和展开，秩序和混乱，以及8。淀粉样蛋白（通过错误折叠死亡）。公共卫生相关性：生物聚合物（蛋白质，RNA，DNA）对于包括信号转导，代谢和基因表达在内的生物过程至关重要。由于生物聚合物的缺陷与许多人类疾病有关，因此它们是药物靶标，并且越来越多地用作治疗剂。 2010年的生物聚合物戈登研究会议将讨论有关了解生物聚合物的结构，稳定性和动态以及生物聚合物的新功能的最新进展。