Aspen Perinatal Biology Conference

阿斯彭围产期生物学会议

• 批准号: 8004491
• 负责人: LOREN P THOMPSON
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8004491
• 关键词: Address; Adult; Biology; Cardiovascular Diseases; Diabetes Mellitus; Drug Exposure; Educational workshop; Endocrine; Environment; Epigenetic Process; Fetal Development; Fetus; Funding; Gestational Diabetes; Goals; Growth; Health; Hypertension; Hypoxia; Imaging Techniques; Link; Medicine; Molecular; Mothers; Nutrient; Obesity; Outcome; Perinatal; Placentation; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Production; Regulation; Reproductive Medicine; Request for Applications; Research Personnel; Risk; Scientist; Slide; Stress; angiogenesis; career; fetal; fetal programming; forging; global health; graduate student; interest; lecture notes; lectures; multidisciplinary; nutrition; offspring; posters; public health relevance; stressor; symposium

DESCRIPTION (provided by applicant): This application requests funds for support of the Aspen Perinatal Biology Conference on August 28-31, 2010. This Conference is organized every 3 years to encompass topics related to intrauterine stress and its impact on placental development and fetal outcomes. Its focus is to identify perinatal mechanisms that link maternal illnesses during pregnancy and fetal adaptations and has broad implication for understanding maternal/fetal health and the long term consequences of fetal programming on the offspring. Growth restricted fetuses are born with an increased risk of hypertension, diabetes, and obesity. Recent studies have now identified altered nutrition (both the under- and overfed mother), hypoxia, gestational diabetes, preeclampsia, and drug exposure as intrauterine stressors that alter specific cellular mechanisms leading to both immediate consequences in the fetus and lasting effects into adulthood through fetal programming. Because perinatal medicine is a multidisciplinary field, the goal of the conference is to bring together both basic scientists and perinatologists to discuss the maternal, placental and fetal mechanisms that contribute to both normal and altered fetal outcomes. The proposed 2.5 day conference is organized into 3 Plenary Slide Sessions, 1 key note lecture, 2 poster sessions and 2 Workshop Lectures. The 4 specific goals of the conference are: 1) to understand the cellular mechanisms associated with maternal adaptations during pregnancy, 2) to discuss the current mechanisms important in placental function and fetal maturation, 3) to understand the interaction of adverse intrauterine environments on fetal development, and 4) to identify key factors important in contributing to placental/fetal adaptations to adverse pregnancy conditions. The 3 Plenary Sessions will include topics on 1) Maternal Conditions Causing Intrauterine Stress, 2) Placental Mechanisms of Nutrient Transport/Endocrine Production, and 3) Fetal Adaptive Mechanisms. Speakers will include 1) senior investigators, well established in their fields of maternal, placental and fetal mechanisms of adaptation during pregnancy, 2) young investigators, beginning to forge a successful career in reproductive medicine, and 3) postdocs and graduate students. Poster sessions will provide young investigators a format for direct interaction with conferees. The key note lecture will be "Mechanisms of Placental Angiogenesis", which will have broad interest to the field of perinatal biology. The Workshop Lectures will address "Placental Imaging Techniques" and "Molecular Regulation of Epigenetic Mechanisms". This Conference of basic scientists and clinicians, whose broad interests lie in understanding the mechanisms underlying adverse pregnancy outcomes, is expected to generate new ideas on how to address the impact of intrauterine stress in global health issues such as obesity, diabetes, and cardiovascular disease. PUBLIC HEALTH RELEVANCE: This application requests funds for support of the Aspen Perinatal Biology Conference on August 28-31, 2010. This will be a 3d Conference organized into 3 Plenary Slide Sessions, 1 key note lecture, 2 poster sessions and 2 Workshop Lectures. Because perinatal medicine is a multidisciplinary field, the goal of the conference is to bring together both basic scientists and perinatologists to discuss the effects of a stressed intrauterine environment on maternal, placental and fetal mechanisms that contribute to altered fetal outcomes.

描述（由申请人提供）：本申请要求资金支持2010年8月28日至31日的Aspen围产期生物学会议。该会议每3年进行一次，以包含与胎儿内压力及其对胎盘发育和胎儿结果的影响有关的主题。它的重点是确定围产期机制，这些机制将怀孕期间的孕产妇疾病与胎儿适应联系起来，并具有广泛的意义，这对理解孕产妇/胎儿健康以及胎儿编程对后代的长期后果具有广泛的影响。 受限制的胎儿天生有高血压，糖尿病和肥胖的风险增加。最近的研究现已确定营养的改变（不足和过度喂食的母亲），缺氧，妊娠糖尿病，先兆子痫和药物暴露是宫内胁迫，这些疗法会改变特定的细胞机制，从而改变了特定的细胞机制，从而导致胎儿中的直接后果以及通过胎儿程序通过胎儿程序造成持久的影响。由于围产期医学是一个多学科的领域，因此会议的目的是召集基础科学家和周期学家，讨论孕产妇，胎盘和胎儿机制，从而导致正常和改变的胎儿结果。 拟议的2.5天会议分为3个全体幻灯片会议，1个关键便笺讲座，2个海报会议和2次讲习班讲座。会议的4个具体目标是：1）了解与孕妇适应性相关的细胞机制，2）讨论对胎盘功能和胎儿成熟重要的当前机制，3）3）了解不良内环境在胎儿发育中的相互作用和4），以确定对对胎盘适应性造成不良胎盘适应性的关键因素。这3个全体会议将包括关于1）产妇条件的主题，导致宫内应激，2）营养转运/内分泌的胎盘机制，以及3）胎儿自适应机制。演讲者将包括1）高级调查人员，在怀孕期间的孕产妇，胎盘和胎儿适应机制领域良好建立，2）年轻的研究人员，开始在生殖医学领域取得成功的职业，以及3）研究生和研究生和研究生。海报会议将为年轻的调查人员提供一种与同盟直接互动的格式。关键说明讲座将是“胎盘血管生成的机制”，它将引起围产期生物学领域的广泛兴趣。研讨会讲座将解决“胎盘成像技术”和“表观遗传机制的分子调节”。这次基础科学家和临床医生的会议在于了解不良怀孕结果的基本机制，预计将产生有关如何解决肥胖，糖尿病和心血管疾病等全球健康问题影响的新想法。 公共卫生相关性：该申请要求资金支持2010年8月28日至31日的Aspen围产期生物学会议。这将是一个3D会议，该会议组织为3个全体幻灯片会议，1个关键笔记讲座，2个海报会议和2次研讨会讲座。由于围产期医学是一个多学科的领域，因此会议的目的是将基本科学家和周期学家汇总在一起，讨论压力性宫内环境对胎儿，胎盘和胎儿机制的影响，从而有助于改变胎儿的结果。