17th Conference on Hemoglobin Switching

第十七届血红蛋白转换会议

• 批准号: 8005636
• 负责人: George Stamatoyannopoulos
• 金额: $ 2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8005636
• 关键词: Cells; Clinical; Development; Developmental Gene; Developmental Process; Disease; Europe; Event; Faculty; Genetic; Globin; Hematopoiesis; Hemoglobin; Hemoglobinopathies; Inherited; Institutes; International; Interruption; Minority; Molecular; Molecular Biology; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Participant; Postdoctoral Fellow; Research Personnel; Rotation; Scientist; Sickle Cell Anemia; Site; Students; Thalassemia; United States National Institutes of Health; Woman; Work; career; college; disease mechanisms study; effective therapy; human disease; meetings; public health relevance; success; symposium

DESCRIPTION (provided by applicant): The biennial Conferences on Hemoglobin Switching were initiated in 1978 initially with support by NIDDK and NHLBI and have been held thereafter with support by NIDDK, NHLBI and other Institutes of NIH without interruption for 31 years. There are multiple reasons for the resounding success of these Conferences. First and foremost, the Conference organizers (in the past Stamatoyannopoulos and Nienhuis; currently Stamatoyannopoulos, Higgs and Engel) strive to identify and then highlight new discoveries by always including new investigators and studies that impinge on the process of the developmental control of globin genes and the developmental control of hematopoiesis. Second, this is the only venue that brings together basic scientists and clinicians to discuss both the molecular and developmental origins of the hemoglobinopathies, and the development of molecular and cellular treatments. Third, these Conferences have launched the careers of all the current leaders in this field who as postdoctoral fellows and young faculty first presented their work in plenary sessions of the Conferences. Fourth, this is the only Conference on this topic with postdoctoral fellows and students representing over 50% of the participants. Fifth the Conference has consistently provided a Forum for plenary presentations by women and minority investigators. Sixth the Conference is the main international event in this field as illustrated by the attendance of investigators from both inside and outside the US, and by the biennial rotation of its site between the USA and Europe. In 2010 the Conference on Hemoglobin Switching will be held at St. John's College, Oxford UK, where the previous Conferences in Europe have been held. PUBLIC HEALTH RELEVANCE: Project Narrative The most common inherited human diseases worldwide are the thalassemias and sickle cell disease, we understand the genetics and molecular biology of these diseases but we are only at the beginning of devising effective therapies to treat them. This International Conference, held every two years, is the only meeting of its kind, and provides a Forum for sharing information between molecular and cell biologists who study disease mechanisms and their clinical counterparts who treat these diseases. This conference is also consciously more inclusive of young people, women and minorities than any other roughly comparable Forum.

描述（由申请人提供）：1978年，在Niddk和NHLBI的支持下，在1978年开始了关于血红蛋白转换的两年一次会议，此后由NIDDK，NHLBI和其他NIH研究所的支持并在不中断的情况下进行了支持。这些会议取得了巨大成功的原因。首先，会议组织者（过去的Stamatoyannopoulos和Nienhuis；目前的Stamatoyannopoulos，Higgs和Engel）努力识别，然后通过包括新的调查人员和研究构成新的研究人员和研究，这些研究构成新的发现和研究，这些研究影响了全球基因的发育控制以及血型瘤的发展控制过程。其次，这是唯一将基础科学家和临床医生汇集在一起​​讨论血红蛋白病的分子和发育起源的场所，以及分子和细胞处理的发展。第三，这些会议启动了该领域所有现任领导人的职业，他们作为博士后研究员和年轻教师首先在全体会议上展示了他们的工作。第四，这是与博士后研究员和代表50％以上参与者的学生有关此主题的唯一会议。第五会议一直为妇女和少数群体调查员提供了一个论坛。第六届会议是该领域的主要国际活动，如美国内部和外部的调查人员以及美国和欧洲之间的两年一次轮换所示。 2010年，关于血红蛋白转换的会议将在英国牛津大学的圣约翰学院举行，欧洲以前的会议已在那里举行。 公共卫生相关性：项目叙事全球最常见的遗传性人类疾病是Thalassecnemias和镰状细胞疾病，我们了解这些疾病的遗传学和分子生物学，但我们只是在设计有效治疗它们的有效疗法开始时。一次国际会议每两年举行一次，是同类唯一的会议，并为研究疾病机制及其临床对应物的分子和细胞生物学家之间的信息提供了一个论坛。这次会议也比任何其他大致可比的论坛都更有意识地包含年轻人，妇女和少数民族。