UW/FHCRC TRAINING IN HEMOGLOBINPATHIES, GENOMICS AND PROTEOMICS

UW/FHCRC 血红蛋白病、基因组学和蛋白质组学培训

• 批准号: 7475274
• 负责人: George Stamatoyannopoulos
• 金额: $ 5.9万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7475274
• 关键词: Biological; Biological Assay; Biology; Complement; Complex; Computational Biology; Data; Educational Background; Faculty; Funding; Genome; Genomics; Goals; Hemoglobinopathies; Institution; Interdisciplinary Study; Journals; Knowledge; Laboratories; Measures; Mentors; Proteins; Proteomics; Research; Research Training; Rotation; Senior Scientist; Sequence Analysis; Series; Training; Training Programs; Universities; Variant; Washington; Work; career; cohesion; computerized tools; programs; tool

We request funds to establish an interdisciplinary training program in hemoglobinopathies, genomicsand proteomics at the University of Washington and affiliated institutions. The program focuses onpreparing postgraduates for a research career that includes knowledge of hemoglobinopathies, genomics, proteomics and coniputational biology. In addition to their research training in hemoglobinopathies, trainees will be engaged in projects that include discovering how a genome encodes the information for gene products to perform complex biological tasks; measuring and analyzing sequence variation; developingtechnologies to accommodate high throughputexperimental assays, and generating new computational tools to analyze gehbmic and prbteomic data. Given the expected wide diversity in educational backgrounds and career goals among our trainees, the program emphasizes highly individualized training and interdisciplinary research. A rtiultidisciplinary group of faculty, selected for their involvement in hemdglobinopathy, genomics and protemics research and for their training record will serve as mentors of the trainees. Senior scientists with a strong record Ofcontributions in the field of hemoglobinopathies will serve as advisors of the trainees They will'advise the trainees in the initial 6 month period of laboratory rotations, iri selection of their course work and in selection of their research mentor. They will also advise the trainees throughout the training period with a goal of keepingtheir focus on application of the genomicsand proteomics tools in answeringimportant questions in the field of hemoglobinopathies. Research experiencewill be complemented with a varietyof didactic courses arid electives. Training on ethical researchconduct is part of the program. Breadthof knowledge and program cohesion are achieved throughtrainee participation in two seminar series that feature genomic researchand computational biology,journal clubs,research in progress, and a variety oftopical discussion groupsled by programfaculty. Training is expectedto last 4 to 5 years of whichthe first three will be supportedby the training program and the remainingby research funds of research mentors or KO8s of the trainee's. ¿ '. '

我们要求资金在血红蛋白病，基因组和 华盛顿大学和会员机构的蛋白质组学。该计划将重点放在首位 研究生涯的研究职业，包括有关血红蛋白病的知识，基因组学，蛋白质组学 和构造生物学。除了他们在血红蛋白疗法方面的研究培训外，学员还将 从事项目，包括发现基因组如何编码基因产品的信息 执行复杂的生物学任务；测量和分析序列变化；发展技术 容纳高透明度测定法，并生成新的计算工具来分析 GEHBMIC和PRBTEOMIC数据。鉴于教育背景和职业目标的预期多样性 在我们的培训中，该计划强调了高度个性化的培训和跨学科研究。一个 教师的rtiultidogery群体，因参与Hemdglobinopathy，基因组学和 保护研究及其培训记录将成为学员的导师。高级科学家 在血红蛋白病领域的贡献记录很强，将作为他们训练的顾问 将在最初的6个月的实验室轮换期间，授予学员，iri选择其课程工作 并选择他们的研究导师。他们还将在整个培训期间建议培训 目的是将其专注于基因组学和蛋白质组学工具的应用 血红蛋白病领域的问题。研究经验将通过多样性完成 教学课程干旱选修课。道德研究调查培训是该计划的一部分。广度 知识和程序的凝聚力通过训练性参与两个开创性系列而实现 基因组研究和计算生物学，期刊俱乐部，正在进行的研究以及各种各样的人 讨论由ProgramFulty组成的小组。预计训练将在过去的4到5年中进行，其中前三个将 得到培训计划以及研究导师或KO8的剩余研究基金的支持 实习生的。 �'。'