Oklahoma Rheumatic Disease Research Cores Center (Overall Application)

俄克拉荷马州风湿病研究核心中心（整体申请）

基本信息

批准号：
10016168
负责人：
JUDITH A JAMES
金额：
$ 87.4万
依托单位：
OKLAHOMA MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-07 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10016168
关键词：
Aging Applications Grants Autoimmune Process Autoimmunity Basic Science Biological Assay Biological Markers Biomedical Engineering Brain Cells Clinical Clinical Management Clinical Research Clinical Trials Clinical Trials Design Collaborations Collection Communication Complex Connective Tissue Diseases Consult Cytometry Data Data Set Degenerative polyarthritis Development Diagnosis Diagnostic Disease Distant Evaluation Flow Cytometry Foundations Future Genus Capra Goals Health Human Human Resources Immune response Immunologic Monitoring Indigenous Inflammatory Informatics Information Systems Infrastructure Institutes Institution International Investigation Investments Leadership Literature Lupus Manuscripts Medicine Mentors Methodology Mission Modeling Molecular Monitor NCI Scholars Program National Institute of Allergy and Infectious Disease Oklahoma Pathogenesis Pathologic Patient Selection Patient-Focused Outcomes Patients Phenotype Pilot Projects Precision therapeutics Pregnancy Preparation Prevalence Prevention Prevention trial Procedures Proteomics Public Health Research Research Design Research Infrastructure Research Personnel Resources Rheumatism Rheumatoid Arthritis Rheumatology Sampling Scientist Seasons Services Sjogren&apos s Syndrome Study Subject Symptoms System Systemic Lupus Erythematosus Technology Testing Training Undifferentiated United States National Institutes of Health Work assay development base biobank career clinical care cost data access data warehouse disease classification experience high dimensionality inter-institutional molecular phenotype multidimensional data multidisciplinary outcome forecast patient subsets phenotypic data precision medicine prognostic programs recruit response sample collection systems research therapeutic target transcriptomics

项目摘要

Oklahoma Rheumatic Disease Research Cores Center: Overall Project Summary The Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) unites 25 established Center Investigators, 22 junior center investigators (11 within and 11 outside Oklahoma) and a newly proposed Reichlin/Capra Scholar program to develop early-stage investigators with outstanding promise in rheumatic disease research. The mission of the ORDRCC is to optimize interactions between basic, clinical and analytic scientists focused on deciphering pathogenesis, prediction, prevention and precision therapeutic selection in rheumatic disease. As the foundation for this mission, the ORDRCC has developed some of the largest existing cross-sectional and longitudinal collections of SLE, Sjogren’s, and rheumatoid arthritis. With a CAP- certified Biorepository and electronic clinical research management system, the ORDRCC continues to expand these large, well-characterized collections and to build others in osteoarthritis, undifferentiated connective tissue disease and autoimmune rheumatic disease pregnancies. The ORDRCC-supported collections and biorepository infrastructure are critical resources for many established rheumatic disease investigators and inter-institutional rheumatic disease collaborations, and have helped launch the independent careers of 27 former New Investigators. Without ORDRCC support, these collections would be unavailable, as would the basic infrastructure that enables the Biorepository to serve several NIH-sponsored and other investigator- initiated clinical trials at a fraction of the cost of a commercial biorepository. The Clinical Characterization and Biorepository Core (CCBC) which houses these collections, also provides clinical research units to aid in study recruitment, regulatory assistance for junior investigators and Scholars, and translational informatics to help visualize complex datasets of clinical and molecular data. The newly revised Human Phenotyping Core (HPC) empowers ORDRCC investigators to use the latest high-content phenotyping methodologies for precision medicine approaches by providing experienced technical personnel, proven standard operating procedures and training for sample preparation, assay development, data QC, and analytical assistance. The HPC helps ORDRCC investigators perform and analyze high-dimensional cytometry, single-cell transcriptomics and proteomics, high-content flow cytometry for functional immune response assays, molecular phenotyping by transcriptomics, and high-throughput testing of soluble biomarkers. Together the CCBC and HPC will integrate clinical and molecular information to identify molecularly homogeneous subsets of subjects for studies or trials. The Administrative Core serves as the central management and communication hub for the ORDRCC and coordinates a multi-disciplinary enrichment program, including a Rheumatic Disease Research Forum, a vibrant and successful Pilot Projects program, a new Proposal Development Core to assist investigators with developing robust manuscripts and competitive grant applications and a new Expanding Rheumatic Disease Research Colloquium to forge interactions between ORDRCC scientists and investigators from other fields.

俄克拉荷马州风湿病研究核心中心：总体项目摘要俄克拉荷马州风湿病研究核心中心 (ORDRCC) 建立了 25 个中心调查员、22 名初级中心调查员（俄克拉荷马州内 11 名、俄克拉荷马州外 11 名）以及新提议的 Reichlin/Capra 学者计划旨在培养在风湿病领域具有杰出前景的早期研究人员 ORDRCC 的使命是优化基础、临床和分析之间的相互作用。科学家们专注于破译发病机制、预测、预防和精准治疗选择作为这一使命的基础，ORDRCC 开发了一些最大的药物。现有的 SLE、干燥病和类风湿性关节炎的横断面和纵向数据集。经过认证的生物样本库和电子临床研究管理系统，ORDRCC 不断扩展这些大型的、特征明确的集合并建立了骨关节炎、未分化结缔组织的其他集合 ORDRCC 支持的组织疾病和自身免疫性风湿病妊娠。生物样本库基础设施是许多风湿病研究人员的重要资源，机构间风湿病合作，并帮助 27 人开启了独立职业生涯如果没有 ORDRCC 的支持，这些藏品将不可用，同样如此。使生物样本库能够为 NIH 资助的多名研究人员和其他研究人员提供服务的基本基础设施 - 以商业生物样本库成本的一小部分启动临床试验。生物样本库核心 (CCBC) 拥有这些藏品，还提供临床研究单位来协助研究招聘、对初级研究人员和学者的监管援助以及翻译信息学以提供帮助可视化临床和分子数据的复杂数据集新修订的人类表型核心 (HPC)。使 ORDRCC 研究人员能够使用最新的高内涵表型分析方法来实现精确性通过提供经验丰富的技术人员、经过验证的标准操作程序来实现医学方法 HPC 可以提供样品制备、分析开发、数据质量控制和分析协助方面的培训。 ORDRCC 研究人员执行并分析高维细胞计数、单细胞转录组学和蛋白质组学、功能性免疫反应的高内涵流式细胞术、分子表型分析 CCBC 和 HPC 将整合转录组学和可溶性生物标志物的高通量测试。临床和分子信息，用于识别用于研究或试验的分子同质子集的受试者。行政核心作为 ORDRCC 的中央管理和通信中心，协调多学科丰富计划，包括风湿病研究论坛、充满活力和成功的试点项目计划，一个新的提案开发核心，可协助调查人员开发可靠的手稿和竞争性资助申请以及新的扩展风湿病研究研讨会旨在促进 ORDRCC 科学家和其他领域研究人员之间的互动。