Biocontainment Engineering

生物防护工程

• 批准号: 8080177
• 负责人: Lee Thompson
• 金额: $ 214.29万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8080177
• 关键词: Air; Animals; Area; Autopsy; Biological; Breathing; Centers for Disease Control and Prevention (U.S.); Chemicals; Containment; Core Facility; Decontamination; Devices; Engineering; Ensure; Environment; Environmental air flow; Equipment; Health; Laboratories; Logistics; Maintenance; Monitor; Particulate; Positive-Pressure Respiration; Procedures; Process; Risk Assessment; Safety; Schedule; Services; System; Training; Vent; Work; air filter; air filtration; monitoring device; operation; pressure; programs; repaired

The Biocontainment Engineering Core will provide service in support of maintaining and monitoring the specific containment devices required for the GNL. Both primary and secondary containment features use directional airflow, negative pressure, High Efficiency Particulate Air (HEPA) filter, perimeter integrity to provide these protective capabilities. This core will provide annual decontamination and recertifications of all primary containment devices to include Biological Safety Cabinets, Class III aerobiology cabinets, downdraft necropsy tables, procedure tables, animal isolators and Chemical Fume hood. It will also provide repair capabilities for these primary containment devices. To ensure that Biocontainment capabilities are maintained in a BSL-3 and BSL-4 environment requires constant monitoring and recertification of the many aspects of the facility to ensure proper and safe operations. This core will provide monitoring of all HEPA filtration devices installed in the system. This will include decontamination and recertification of HEPA device installed in ventilation systems, effluent vent lines, pressure monitoring devices, breathing air systems and positive pressure breathing air suits. This core will also be responsible for the gaseous decontamination of equipment from the contained spaces, decontaminations of laboratories, and effluent decontamination systems. Working with the Facility and Logistics Services Core, the Biocontainment Engineering Core will perform risk assessment on all engineering features of the facility, identify pieces of equipment or systems that require decontamination or isolation to facilitate maintenance operations, and develop SOP's that will ensure safety during these operations. Utilizing information developed during the commissioning process these cores will develop overall operational SOP's for the facility. This core will schedule and coordinate with scientific programs, Health, Safety and Training Services Core and Facility and Logistics Services Core the shut down of the various containment areas for annual recertification and commissioning. This will enable the facility to ensure compliance with the requirements of the CDC and USDA Select Agent.

生物疗法工程核心将提供服务，以支持和监视 GNL所需的特定遏制设备。主要和次要遏制功能都使用 方向气流，负压，高效率颗粒空气（HEPA）滤波器，周长完整性 提供这些保护功能。该核心将提供年度净化和重新认证 所有主要的遏制设备，包括生物安全柜，III类的特技生物学机柜， 向下气流表，手术表，动物隔离器和化学烟雾罩。它也将提供 这些主要遏制设备的维修功能。确保生物内在功能是 维持在BSL-3和BSL-4环境中需要持续监控和重新认证。 设施的各个方面，以确保适当和安全的操作。该核心将提供所有HEPA的监视 系统中安装的过滤设备。这将包括HEPA的去污和重新认证 设备安装在通风系统，废水排气管线，压力监测设备，呼吸空气中 系统和正压呼吸空气西服。该核心也将负责气体 从包含的空间，实验室的净化和废水中净化设备的净化 去污系统。与设施和物流服务核心合作，生物内在 工程核心将对设施的所有工程特征进行风险评估，确定 需要去污或隔离以促进维护操作的设备或系统，并且 开发SOP，以确保在这些操作中确保安全。利用在 调试过程这些核心将为该设施开发整体运营SOP。这个核心将 安排并与科学计划，健康，安全和培训服务核心和设施进行协调 物流服务核心关闭各个遏制区域，以进行年度重新认证和 调试。这将使该设施能够确保符合CDC的要求和 USDA选择代理。