Innovative Tools for Chemical Synthesis: Cyclase-Inspired Catalysis, Shuttle Catalysis, and Tandem Catalysis

化学合成的创新工具：环化酶催化、穿梭催化和串联催化

• 批准号: 9788994
• 负责人: Vy M Dong
• 金额: $ 3.34万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9788994
• 关键词: Address; Aldehydes; Alkenes; Alkynes; Amines; Architecture; Carbon; Catalysis; Chemical Structure; Chemicals; Clothing; Cobalt; Coupling; Data; Hydrogen Bonding; Knowledge; Laboratories; Life; Medicine; Methods; Modernization; Molecular; Nature; Nickel; Nitrogen; Organic Chemistry; Research; Rhodium; Ruthenium; Savings; Therapeutic; catalyst; chemical synthesis; design; functional group; human disease; innovation; insight; invention; metalloenzyme; programs; tool

Project(Summary!! This research program focuses on addressing gaps in chemical structure and reactivity through the power of catalysis. Inspired by metalloenzymes, my laboratory designs, studies, and invents innovative tools for chemical synthesis that overcome the need for chiral auxiliaries and stoichiometric activating agents. The cross-coupling methods proposed feature the use of common functional groups (e.g., aldehydes, amines, alkynes, and alkenes) and generate new carbon-carbon and carbon-nitrogen bond with excellent atom economy. A wide range of chiral motifs can be accessed by this approach and the insights gained will ultimately enhance our ability to control chemical reactivity and build chemical structures. In turn, this knowledge greatly augments our ability to discover new medicines for treating human diseases, as well as prepare these medicines on large scale. The program features many new directions supported by compelling preliminary data including cyclase-inspired catalysis, shuttle catalysis, and tandem catalysis. Besides the practical value, this program will provide fundamental insights into the use of various catalysts, including rhodium, ruthenium, cobalt, and nickel, for the activation and functionalization of carbon-hydrogen bonds—a long standing challenge in modern organic chemistry.

项目（摘要！！ 该研究计划的重点是通过动力解决化学结构和反应性方面的差距 受金属酶的启发，我的实验室设计、研究和发明了创新工具。 化学合成克服了对手性助剂和化学计量活化剂的需求。 提出的交叉偶联方法的特点是使用常见的官能团（例如醛、胺、 炔烃和烯烃）并生成具有优良原子的新碳-碳和碳-氮键 通过这种方法可以获取广泛的手性基序，并且获得的见解将会。 最终增强我们控制化学反应性和构建化学结构的能力。 知识极大地增强了我们发现治疗人类疾病的新药的能力，以及 该计划具有许多新方向的支持。 令人信服的初步数据，包括环化酶催化、穿梭催化和串联催化。 除了实用价值外，该计划还将提供对各种催化剂的使用的基本见解， 包括铑、钌、钴和镍，用于碳氢的活化和功能化 键——现代有机化学中长期存在的挑战。