Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular Probes

化学合成的创新工具：金属氢化物催化、药用基序和分子探针

• 批准号: 10624041
• 负责人: Vy M Dong
• 金额: $ 47.49万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624041
• 关键词: Address; Aldehydes; Alkenes; Alkynes; Amines; Architecture; Biology; Carbon; Catalysis; Chemicals; Cobalt; Copper; Coupling; Environment; Friends; Medicine; Metals; Methods; Microscopy; Modernization; Molecular; Molecular Probes; NMR Spectroscopy; Nature; Nitrogen; Organic Synthesis; Periodicity; Pharmaceutical Chemistry; Research Project Summaries; Rhodium; Science; Styrenes; Theoretical Studies; Therapeutic; Training; Transition Elements; cancer immunotherapy; catalyst; chemical synthesis; cyclopropene; design; design and construction; diene; drug discovery; experimental study; functional group; innovation; insight; invention; theories; tool; unsaturated bonds

Project Summary Research and training in organic synthesis impacts all fields of science that require the design and construction of molecular architecture. This project will advance catalytic methods, including hydroacylation and hydroamination, as attractive and powerful tools for chemical synthesis. The coupling methods proposed are modern and innovative because they rely on common functional groups (e.g., aldehydes, amines) to generate new carbon-carbon and carbon-nitrogen bonds from unsaturated partners (e.g., styrenes, dienes, cyclopropenes), with high selectivity and atom economy. Through experimental and theoretical studies, this project will yield fundamental insights into the mechanism of various transition metal catalysts, including rhodium, cobalt, and copper. Beyond catalysis and mechanistic studies, we plan to build chemical motifs of high significance to the field of drug discovery. We target privileged motifs (e.g., chiral nitrogen-containing heterocycles) and explore chemical space (e.g., tricyclic cages bearing high sp3 character). Through partnerships with experts in other fields, we address exciting challenges in fluorescent microscopy, NMR spectroscopy, and cancer immunotherapy by designing functional molecules. This project demonstrates innovation in making molecules at the interface of catalysis, medicinal chemistry, and biology.

项目概要 有机合成的研究和培训影响所有需要设计和建造的科学领域 分子结构。该项目将推进催化方法，包括加氢酰化和 加氢胺化作为化学合成中有吸引力且强大的工具。提出的耦合方法是 现代且创新，因为它们依靠常见的官能团（例如醛、胺）来生成 来自不饱和伙伴（例如苯乙烯、二烯、 环丙烯），具有高选择性和原子经济性。通过实验和理论研究，这 该项目将对各种过渡金属催化剂的机理产生基本的见解，包括铑， 钴和铜。除了催化和机理研究之外，我们计划构建高化学基序 对药物发现领域具有重要意义。我们的目标是特权基序（例如手性含氮基序） 杂环）并探索化学空间（例如，具有高 sp3 特征的三环笼）。通过 与其他领域的专家合作，我们解决荧光显微镜、核磁共振方面令人兴奋的挑战 通过设计功能分子进行光谱学和癌症免疫治疗。该项目展示了 在催化、药物化学和生物学界面制造分子的创新。

项目成果

A diverse view of science to catalyse change.

多样化的科学观点可以促进变革。

• 发表时间: 2020
• 影响因子: 21.8
• 作者: Urbina;Jilani, Safia Z;Speight, Isaiah R;Bojdys, Michael J;Friščić, Tomislav;Stoddart, J Fraser;Nelson, Toby L;Mack, James;Robinson, Renã A S;Waddell, Emanuel A;Lutkenhaus, Jodie L;Godfrey, Murrell;Abboud, Martine I;Aderinto
• 通讯作者: Aderinto

Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis.

通过立体选择性氢化和串联催化减少有机合成中的挑战。

• DOI: 10.1021/jacs.1c00750
• 发表时间: 2021-05-12
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Parker, Patrick D.;Hou, Xintong;Dong, Vy M.
• 通讯作者: Dong, Vy M.

A Diverse View of Science to Catalyse Change.

促进变革的多元化科学观点。

• 发表时间: 2020-10-12
• 作者: Urbina;Jilani, Safia Z;Speight, Isaiah R;Bojdys, Michael J;Friščić, Tomislav;Stoddart, J Fraser;Nelson, Toby L;Mack, James;Robinson, Renã A S;Waddell, Emanuel A;Lutkenhaus, Jodie L;Godfrey, Murrell;Abboud, Martine I;Aderinto
• 通讯作者: Aderinto

Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis.

通过 Ni 催化对 1,3-二烯进行对映选择性加氢烷氧基化。

• 发表时间: 2023-02-10
• 影响因子: 15
• 作者: Li, Qi;Wang, Zhen;Dong, Vy M;Yang, Xiao
• 通讯作者: Yang, Xiao

Tandem Catalysis: Transforming Alcohols to Alkenes by Oxidative Dehydroxymethylation.

串联催化：通过氧化脱羟甲基化将醇转化为烯烃。

• DOI: 10.1021/jacs.8b06069
• 发表时间: 2018-08-15
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Wu X;Cruz FA;Lu A;Dong VM
• 通讯作者: Dong VM