Core A - AdministrativeCore/Biocomputational Unit

核心 A - 管理核心/生物计算单元

基本信息

批准号：
10397004
负责人：
ANA MARIA CUERVO
金额：
$ 26.54万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-02-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10397004
关键词：
Administrative Personnel Advisory Committees Age Aging Alzheimer&apos s Disease Animal Model Animals Arbitration Area Autophagocytosis Awareness Biology of Aging Biometry Biostatistics Core Budgets Communication Communities Computer software Continuing Education Custom Data Data Analyses Data Collection Data Storage and Retrieval Database Management Systems Deterioration Disease Disputes Educational process of instructing Educational workshop Evaluation Experimental Designs Formulation Funding Future Geroscience Goals Grant Human Resources Individual Institutes Institution Joints Maintenance Mentors Mission Molecular Monitor Online Systems Output Predisposition Procedures Program Research Project Grants Progress Reports Protocols documentation Quality Control Reagent Reproducibility Research Research Activity Research Design Research Personnel Research Project Grants Resolution Resources Sampling Schools Scientist Secure Services Ships Standardization Statistical Data Interpretation Statistical Methods Techniques Testing Text Time Training Training Programs age related body system central database cohesion data curation data integration data management functional decline interest investigator training large datasets material transfer agreement meetings member power analysis programs proteostasis proteotoxicity symposium tool training opportunity

项目摘要

Summary The Administrative Core will continue coordinating the different activities of the four Projects and four Cores of this Program Project (PP). To respond to the demands of the different projects and to properly integrate the large amount of data that will be generated by projects and cores during this period, we have included as a new core component the Biostatistics and Data Management Unit (referred in the PP text as Biostatistics Unit) that will be fully dedicated to data analysis, management, and integration. The long-term goal of this core is two-fold: 1) to serve as the center of integration for the different parts of this collaborative effort and as a liaison of the PP with investigators and resources in and outside our school and 2) to assure that all data will be appropriately collected, managed, analyzed and integrated. The specific aims of this two-component core are: A) Administration (AC): 1) to provide the members of the PP with dedicated administrative and secretarial support required for the functioning of their programs, 2) to coordinate approval for transferring of materials and reagents to other members of the scientific community, 3) to facilitate communication among the different PP members, 4) to monitor and evaluate the scientific progress of the PP, 5) to promote interactions of the PP with Centers with related interests in our school and outside, 6) to increase awareness for aging research. B) Biostatistics and Data Management (BDMU): 1) to provide guidance on study design and formulation of hypothesis, 2) to develop a secure central database system, 3) to implement state-of-the-art techniques for data analysis, 4) to assist with findings interpretation/dissemination, 5) to offer training opportunities in statistical methods. Components: the administrative service, the Executive Committee and the Scientific Advisory Committee (overseen and coordinated by the director) and the experts of the BDMU (overseen by the unit director). Services offered: A) administrative and secretarial support exclusively tailored the needs of this PP (ordering of reagents and supplies, financial and progress reports, assistance with budget management, handling of material transfer agreements), organization of weekly meetings, monthly work-in-progress and of the biannual meetings with the Scientific Advisory Committee. B) experimental design, power analysis, data collection planning, data analysis, large data curation, web-based data integration, data storage, training on statistical analysis and on best practices to assure rigor and reproducibility. Relevance: This core is essential for integration of projects and cores into a cohesive program that allows for faster and efficient progress toward the elucidation of the basis for functional decline of organs and systems with age and in the context of Alzheimer’s disease-related proteotoxicity. In the basis for this cohesive program is the free and efficient communication of scientific results among the members of the program, the active review of progress and utilization of resources and the delineation of a common future goal and direction.

概括行政核心将继续协调四个项目和四个项目的不同活动本计划的核心项目（PP）响应不同项目的需求并适当地进行。整合这段时间项目和核心将产生的大量数据，我们有作为新的核心组成部分包括生物统计和数据管理单位（在 PP 文本中提及）作为生物统计部门）将完全致力于数据分析、管理和整合。该核心的长期目标有两个：1）作为不同部分的集成中心这一合作努力的一部分，并作为 PP 与我们内外的调查人员和资源的联络人学校；2) 确保所有数据得到适当收集、管理、分析和整合。这个由两部分组成的核心的具体目标是： A) 管理 (AC)： 1) 为成员提供 PP 为其计划的运作提供专门的行政和秘书支持， 2) 协调批准向科学组其他成员转让材料和试剂社区，3) 促进不同 PP 成员之间的沟通，4) 监督和评估 PP 的科学进步，5) 促进 PP 与我们的相关利益中心的互动学校内外，6) 提高对衰老研究的认识 B) 生物统计学和数据管理。 (BDMU)：1) 为研究设计和假设的制定提供指导，2) 开发一个安全的中心数据库系统，3) 实施最先进的数据分析技术，4) 协助发现结果解释/传播，5) 提供统计方法方面的培训机会。组成部分：行政部门、执行委员会和科学咨询委员会（由主任领导和协调）和BDMU专家（由单位主任领导）。提供的服务：A) 专门针对本 PP 的需求量身定制的行政和秘书支持（订购试剂和用品、财务和进度报告、预算管理协助、处理材料转移协议）、组织每周会议、每月进行中的工作和与科学咨询委员会每年两次举行的会议 B) 实验设计、功效分析、数据收集规划、数据分析、大数据管理、基于网络的数据集成、数据存储、统计分析和最佳实践培训，以确保严谨性和可重复性。相关性：该核心对于将项目和核心集成到一个有凝聚力的计划中至关重要，该计划允许在阐明器官和系统功能衰退的基础方面取得更快、更有效的进展与年龄和阿尔茨海默病相关的蛋白质毒性的背景下，这是这个有凝聚力的计划的基础。是该计划成员之间自由有效地交流科学成果，积极的审查进展和资源利用情况，并描绘共同的未来目标和方向。