Approach Bias Modification for Co-Occurring Cannabis and Alcohol Use among Treatment-Seeking Adolescents

针对寻求治疗的青少年同时吸食大麻和酗酒的方法偏差修正

基本信息

批准号：
10375380
负责人：
Austin Matthew Hahn
金额：
$ 20.9万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10375380
关键词：
Adolescence Adolescent Adult Aftercare Age Alcohol abuse Alcohol consumption Alcohols Area Award Behavioral Brain Cannabis Categories Clinical Trials Cognitive Communication Computers Cues Data Development Development Plans Drug Exposure Ecological momentary assessment Effectiveness Electroencephalogram Electroencephalography Ensure Environment Etiology Evaluation Event-Related Potentials Exhibits Funding Goals Image Intervention Joystick Knowledge Maintenance Measures Mediating Mediator of activation protein Mentors Mentorship Methods Modification National Institute of Drug Abuse National Institute on Alcohol Abuse and Alcoholism Neurocognitive Neurologic Participant Performance Pharmaceutical Preparations Play Portraits Positioning Attribute Process Productivity Publications Randomized Randomized Controlled Trials Reporting Research Research Personnel Resources Rewards Role SECTM1 gene Stimulus Strategic Planning Structure Testing Time Training addiction adolescent substance use alcohol effect alcohol use disorder brief intervention career career development computerized cost craving design emerging adult experience experimental study implicit bias innovation intervention effect marijuana use marijuana use disorder marijuana user neglect post intervention programs prospective response substance use substance use treatment underage drinker underage drinking

项目摘要

PROJECT SUMMARY/ABSTRACT Alcohol and cannabis are the first and second most commonly used substances among adolescents. Adolescence is a period of considerable development, making the adolescent brain particularly vulnerable to negative effects of alcohol and cannabis use. Developing and testing interventions that target both alcohol and cannabis use during adolescence are vital to decreasing costly consequences. Biases in cognitive processing of drug-related stimuli play an important role in the development and maintenance of problematic substance use. The Approach-Avoidance Task (AAT) is a computerized program, effective in assessing implicit approach biases for both alcohol and cannabis, in which participants push or pull a joystick in response to an irrelevant feature of an image presented on a computer screen (e.g., push when in portrait, pull when in landscape). A modified version of the AAT (mAAT) is also used as a Cognitive Bias Modification (CBM) intervention, to retrain participants’ implicit biases toward or away from stimuli by presenting the target stimuli predominantly in one format (e.g., push or pull). Despite research demonstrating the effectiveness of mAAT interventions to reduce problematic alcohol and cannabis use, there is a dearth of research examining this intervention among adolescents. The proposed research will test a pilot randomized controlled trial of an integrated mAAT intervention to target co-occurring alcohol and cannabis use among treatment-seeking adolescents (N=52). Specific aims include to test the effect of the intervention on approach biases for cannabis/alcohol stimuli (Aim 1) and cannabis/alcohol use at 1- and 3-months post-intervention (Aim 2), and to examine the role of intentions and cravings as mediators in the relationship between treatment condition and use. The research environment, facilities, and resources at MUSC are ideally suited for mentored career development in addiction research. K23 training objectives are to: 1) increase knowledge of etiological and treatment mechanisms for cannabis use; 2) acquire essential knowledge and experience across the stages of clinical trial research among treatment-seeking adolescents with substance use problems, including incorporating EMA methods; 3) develop expertise in CBM; 4) gain experience incorporating EEG to identify change mechanisms in substance use interventions; and 5) enhance scientific communication and overall academic productivity. Structured mentorship from Drs. Carla Kmett Danielson, Lindsay Squeglia, Lisa McTeague, and Robert Miranda Jr. will ensure training goals are met. The candidate’s long-term career goal Is to direct a research portfolio that: 1) develops and tests innovative intervention approaches for substance use problems among adolescents and emerging adults; 2) delivers these innovative interventions in existing real-world settings; and 3) identifies change mechanisms within interventions using multiple units of analysis. The training proposed herein is designed to develop expertise across these areas, represents a clear progression from prior training and would not be possible without this K23.

项目概要/摘要酒精和大麻是青少年中第一和第二最常用的物质。青春期是一个相当大的发展时期，使得青少年的大脑特别容易受到制定和测试针对酒精和大麻使用的干预措施。青春期吸食大麻对于减少认知过程中的代价高昂的后果至关重要。与药物相关的刺激在有问题的物质使用的发展和维持中发挥着重要作用。接近回避任务（AAT）是一个计算机化程序，可有效评估隐性接近偏差对于酒精和大麻，参与者推动或拉动操纵杆以响应与酒精和大麻无关的特征计算机屏幕上呈现的图像（例如，纵向时推，横向时拉）。 AAT (mAAT) 版本也用作认知偏差修正 (CBM) 干预，以重新训练通过优先呈现目标刺激，参与者对刺激的隐性偏见尽管研究表明 mAAT 干预措施可以有效减少风险。有问题的酒精和大麻使用，但缺乏研究来检验这种干预措施拟议的研究将测试综合 mAAT 的试点随机对照试验。针对寻求治疗的青少年同时使用酒精和大麻的情况进行干预（N=52）。具体目标包括测试干预措施对大麻/酒精刺激方法偏差的影响（目标 1) 以及干预后 1 个月和 3 个月的大麻/酒精使用情况（目标 2），并检查意图的作用和渴望作为治疗条件和使用之间关系的中介。 MUSC 的设施和资源非常适合 K23 成瘾研究的指导职业发展。培训目标是： 1) 增加对大麻使用病因和治疗机制的了解；2) 在寻求治疗的人中获得临床试验研究各个阶段的基本知识和经验有物质使用问题的青少年，包括纳入 EMA 方法；3) 发展 CBM 方面的专业知识； 4) 获得结合脑电图的经验，以确定药物使用干预措施的变化机制；以及 5) 增强卡拉博士的科学交流和整体学术生产力。 Kmett Danielson、Lindsay Squeglia、Lisa McTeague 和 Robert Miranda Jr. 将确保实现训练目标。候选人的长期职业目标是指导一个研究组合：1）开发和测试创新针对青少年和新兴成年人的药物使用问题的干预方法；2) 这些措施能够实现现有现实环境中的创新干预措施；3) 确定干预措施中的变革机制本文提出的培训旨在培养跨这些分析的专业知识。领域，代表了之前培训的明显进步，如果没有 K23，这是不可能实现的。