Biospecimen-Core

生物样本核心

• 批准号: 10376490
• 负责人: Mauricio Rojas
• 金额: $ 75.06万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10376490
• 关键词: Biospecimen; Core

ABSTRACT Biospecimen Core: Lung and heart function and aging are major determinants of human health and lifespan, respectively. Combined, lung and heart diseases are the leading cause of morbidity and mortality world-wide (WHO’s Global Health Estimates 2020). The Biospecimen Core (BC) will generate high-quality, clinically annotated, and pathologically evaluated specimens from normal human lung and heart (and corresponding vessels and lymph nodes) to provide the fundamental basis for the creation of high-resolution, multi-modal, and multi-dimensional senescence maps. The BC investigators will use their expertise in collecting, processing, annotating, classifying, and distributing tissue samples and primary cells lines for lung and heart senescence mapping. The core will excel in providing already catalogued tissues with as little ischemia-induced artifacts as possible, and meet all legal and ethical standards including broad donor consent. The BC follows NIH/NCI Best Practices for Biorepositories, with standard operating procedures (SOPs) in place to ensure the highest biospecimen and clinical information quality to meet all legal and ethical standards. The biorepository efforts are approved through OSU, Pitt, and URMC IRB protocols that cover the procurement, processing, and distribution of human biospecimens. The BC will collect whole tissue from humans across the lifespan and will provide whole tissue, precision cut tissue slices (PCTS), and purified cells to the TriState SenNet TMC. Together with the Data Analysis Core (DAC), the BC will use established metadata collection protocols to collect metadata in a consistent and interoperable format.

抽象的 生物样本核心：肺和心脏功能以及衰老是人类健康和寿命的主要决定因素， 肺病和心脏病分别是全世界发病率和死亡率的主要原因。 （世界卫生组织 2020 年全球健康估计）生物样本核心 (BC) 将产生高质量的临床样本。 来自正常人肺和心脏（以及相应的 血管和淋巴结），为创建高分辨率、多模式和 BC 研究人员将利用他们的专业知识来收集、处理、 注释、分类和分配肺和心脏衰老的组织样本和原代细胞系 核心将擅长为已编目的组织提供尽可能少的缺血引起的伪影。 BC 遵循 NIH/NCI Best 的要求。 生物样本库实践，制定标准操作程序 (SOP) 以确保最高的 生物样本和临床信息质量满足所有法律和道德标准。 通过 OSU、Pitt 和 URMC IRB 协议批准，涵盖采购、加工和分销 BC 将收集人类整个生命周期的完整组织，并提供完整的样本。 组织、精密切割组织切片 (PCTS) 和纯化细胞与数据一起传输至 TriState SenNet TMC。 分析核心 (DAC)，BC 将使用已建立的元数据收集协议来收集元数据 一致且可互操作的格式。