High spatial resolution dedicated head and neck PET system based on cadmium zinc telluride detectors

基于碲化镉锌探测器的高空间分辨率专用头颈 PET 系统

• 批准号: 9789282
• 负责人: Shiva Abbaszadeh
• 金额: $ 64.1万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789282
• 关键词: 3-Dimensional; Address; Aftercare; Algorithms; Animals; Anodes; Area; Beds; Calibration; Cathodes; CdZnTe; Charge; Clinic; Clinical Research; Collection; Crystallization; Detection; Development; Diagnosis; Diagnostic; Disease; Elements; Emission-Computed Tomography; Engineering; Evaluation; Event; Exhibits; Floor; Foundations; Functional Imaging; Goals; Head and Neck Cancer; Head and neck structure; Hospitals; Hot Spot; Illinois; Image; Invaded; Knowledge; Larynx; Lead; Malignant Neoplasms; Methods; Mucous Membrane; Neck; Noise; Nuclear; Patient-Focused Outcomes; Patients; Performance; Photons; Physicians; Plasma; Positioning Attribute; Positron-Emission Tomography; Probability; Procedures; Property; Protocols documentation; Public Health; Radiation; Radiology Specialty; Recovery; Recurrence; Research; Research Personnel; Research Project Grants; Resectable; Resolution; Scanning; Scheme; Semiconductors; Staging; Surface; System; Technology; Thinness; Thyroid cartilage structure; Time; Tissues; Translating; United States; Universities; Validation; X-Ray Computed Tomography; advanced system; base; cancer diagnosis; cancer imaging; cancer recurrence; cancer therapy; chemotherapy; data acquisition; design; detector; electric field; experience; image reconstruction; imaging approach; imaging platform; imaging system; improved; in vivo; individualized medicine; industry partner; kinematics; lymph nodes; millimeter; mortality; novel; outcome forecast; photon-counting detector; prototype; success; treatment planning; tumor; tumor growth; voltage

PROJECT SUMMARY Current head and neck cancer diagnosis and treatment planning suffers from poor spatial resolution of whole-body positron emission tomography (WB-PET) scans. In the neck, where tissue layers are thin, the spatial resolution of WB-PET (4-6 mm) is not sufficient to evaluate small lymph nodes (<5 mm), establish how far the tumor has invaded locally, and guide the decision to resect a tumor rather than irradiate and deliver chemotherapy. This proposal, responsive to PAR-18-009, “Academic-Industrial Partnerships to Translate and Validate in vivo Cancer Imaging Systems,” seeks to address this problem by translating high resolution radiation detection technology to head and neck imaging. The project research team consists of researchers from the Department of Nuclear, Plasma, and Radiological Engineering at the University of Illinois at Urbana-Champaign and eV Products Inc., a world leader in semiconductors for radiation detection. To achieve its goal, this research will pursue the design, development, optimization, characterization, and validation of a dedicated head and neck PET scanner. The proposed system will be the first head and neck scanner to exhibit features as small as 1 mm with high photon sensitivity, enabled by the use of high energy and spatial resolution properties of cadmium zinc telluride (CZT) crystals. This system will be integrated into a transportable stage and is designed to not interfere with the conventional workflow of the WB- PET scan procedure, and has the additional attraction of being used for dynamic PET studies. We expect that this dedicated head and neck PET imaging system will deliver the following new capabilities: i) detection and evaluation of small lymph nodes, ii) improved treatment planning and determining the extent of the tumor growth, and iii) improved confidence in differentiating post-treatment change from tumor recurrence. The system will consist of two panels and have an adjustment for panel-to-panel separation distance. Each panel contains 150, 4x4x0.5 cm3 cross-strip CZT crystals covering a 20x15 cm2 panel area. The crystals will be mounted in an edge-on configuration for increased photon detection efficiency. A novel event recovery scheme based on the 3D position sensitive cross-strip crystals will be developed to recover multiple interaction photon events, reject random events, and significantly increase the photon sensitivity of the system. In the final year of the project, a study consisting of 20 patients will be conducted to evaluate the performance of the developed prototype and validate the potential benefits.

项目概要 目前的头颈癌诊断和治疗计划空间有限 全身正电子发射断层扫描 (WB-PET) 扫描的分辨率 在颈部的位置。 组织层很薄，WB-PET（4-6毫米）的空间分辨率不足以评估 小淋巴结（<5毫米），确定肿瘤局部侵犯的程度，并指导 决定切除肿瘤而不是进行照射和化疗。 响应 PAR-18-009，“学术界与工业界的合作以在体内进行翻译和验证 癌症成像系统”试图通过转化高分辨率辐射来解决这个问题 该项目研究团队由以下人员组成。 来自核、等离子体和放射工程系的研究人员 伊利诺伊大学厄巴纳-香槟分校和 eV Products Inc. 是该领域的世界领先者 为了实现其目标，这项研究将追求设计， 专用头颈 PET 的开发、优化、表征和验证 所提出的系统将是第一个具有以下功能的头颈扫描仪。 小至 1 毫米，具有高光子灵敏度，通过使用高能量和空间 该系统将集成到碲化镉锌 (CZT) 晶体的分辨率特性中。 一个可移动的阶段，旨在不干扰 WB 的传统工作流程 PET 扫描程序，并具有用于动态 PET 研究的额外吸引力。 我们预计这款专用头颈 PET 成像系统将提供以下新功能 能力：i) 检测和评估小淋巴结，ii) 改进治疗计划 并确定肿瘤生长的程度，以及 iii) 提高区分肿瘤的信心 该系统将由两个面板组成，并具有肿瘤复发引起的治疗后变化。 调整面板与面板之间的间隔距离，每个面板包含 150、4x4x0.5 cm3。 覆盖 20x15 cm2 面板区域的交叉条 CZT 晶体 晶体将安装在一个 提高光子检测效率的边缘配置。 将开发基于 3D 位置敏感的十字带晶体来恢复多个 相互作用光子事件，拒绝随机事件，并显着提高光子灵敏度 在该项目的最后一年，将进行一项由 20 名患者组成的研究。 评估所开发原型的性能并验证潜在的好处。