JHU TRAC: Training and Supporting the Next Generation of TB Researchers

JHU TRAC：培训和支持下一代结核病研究人员

• 批准号: 10593142
• 负责人: Richard E. Chaisson
• 金额: $ 98.07万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-16 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593142
• 关键词: Acceleration; Address; Animal Model; Area; Baltimore; Basic Science; Bioinformatics; Biological Assay; Biometry; Biostatistics Core; Cessation of life; Clinical; Clinical Pharmacology; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Computer Models; Cost Effectiveness Analysis; Country; Data; Development; Diagnosis; Diagnostic; Discipline; Discipline of Nursing; Disease; Economic Models; Effectiveness; Engineering; Ensure; Epidemic; Epidemiology; Funding; Generations; Goals; Government; HIV/TB; Health; Health Services Accessibility; Image; Immunology; In Vitro; Interdisciplinary Study; Intervention; Knowledge; Laboratories; Medicine; Mentors; Microbiology; Mission; Modeling; Mycobacterium tuberculosis; Output; Participant; Pathogenesis; Pharmaceutical Preparations; Pharmacology; Pharmacology Study; Policies; Population Dynamics; Prevention; Productivity; Protocols documentation; Public Health; Research; Research Personnel; Role; Sampling; Schools; Scientist; Services; Site; Specific qualifier value; Strategic Planning; Sum; Talents; Training; Training Programs; Translational Research; Tuberculosis; Underrepresented Populations; United States National Institutes of Health; Universities; World Health Organization; animal imaging; biosafety level 3 facility; career; clinical research site; design; diagnostic tool; drug development; efficacy validation; epidemiological model; evidence base; experience; global health; imaging facilities; improved; innovation; interdisciplinary collaboration; large datasets; mathematical model; meetings; member; microbial; multidisciplinary; next generation; novel; novel diagnostics; outreach; pandemic disease; pharmacokinetics and pharmacodynamics; pharmacometrics; pre-clinical; public health intervention; radiotracer; recruit; research study; symposium; synergism; tool; training opportunity; translational model; tuberculosis treatment

ABSTRACT — JHU TRAC OVERALL Tuberculosis (TB) remains a major global health problem, and advances in the basic and clinical sciences are urgently needed to make progress towards the World Health Organization’s End TB Strategy goal of reducing TB deaths by 95% and new cases by 90% between 2015 and 2035. The Johns Hopkins University (JHU) Center for Tuberculosis Research (CTR) has been a global leader in TB pathogenesis, translational models, diagnostics, drug development, pharmacology, public health interventions, and epidemiological and economic modeling for more than two decades. Research emanating from the CTR and JHU has transformed the treatment of TB infection and disease, elucidated interactions between TB and HIV drugs, validated the efficacy and effectiveness of new diagnostic tools, and contributed to the development of evidence-based policies for global TB control, based on the epidemiology and population dynamics of TB. However, to make further progress in efforts to achieve the END TB goals, additional innovative, cross-disciplinary and impactful research is critical and a new generation of TB scientists must be recruited and trained, particularly among groups nationally underrepresented in health-related research (UHRR). We have assembled a multidisciplinary team of researchers from multiple departments spanning four JHU schools (Medicine, Public Health, Nursing and Engineering), with complementary expertise in microbial pathogenesis, immunology, animal models, imaging, clinical trials, diagnostics, epidemiology, pharmacology and pharmacometrics, computational modeling, and biostatistics, in order to provide added value to the TB research enterprise at JHU optimize training opportunities for junior investigators and support for new, interdisciplinary collaborations, with the goal of addressing key knowledge gaps in TB research. The JHU TRAC team comprises 58 researchers, including 32 experienced TB researchers (19 current members of the CTR), 15 senior researchers new to the TB field, and 11 Early Stage Investigators (ESI). The overarching mission of the JHU TRAC is to advance TB research by promoting innovative, multidisciplinary collaborations and by recruiting, training and supporting junior Investigators, especially among UHRR groups, to develop the next generation of leaders in TB research. To this end, the JHU TRAC will focus on these four areas: 1) Enhance the integration, productivity and impact of JHU TB research; 2) Provide mentoring, support, and pilot funding for the next generation of TB researchers, and to increase the pipeline of junior investigators from UHRR groups; 3) Support TB researchers with direct services from a Clinical Core and three Scientific Cores; 4) Contribute to the END TB goals through global engagement, training, outreach, and collaboration with partners in high-burden countries. The JHU TRAC is organized into six Cores (Adminsitrative Core (AC); Developmental Core (DC); Clinical Core (CC); Microbiology, Immunology, Animal Modeling and Imaging (MIAMI) Core; Pharmacology and Pharmacometrics Core (PPC); and Bioinformatics, Modeling and Biostatistics Core (BMBC), which will interact closely with each other to promote synergy in TB research, and ensure that the utility and output of the JHU TRAC is greater than the sum of its parts.

摘要 - Jhu Trac总体 结核病（TB）仍然是一个主要的全球健康问题，基础科学和临床科学的进步是 迫切需要朝着世界卫生组织的结束结核病战略目标取得进步 2015年至2035年期间，死亡人数为95％，新病例的死亡人数为90％。约翰·霍普金斯大学（JHU）中心 结核病研究（CTR）一直是结核病发病机理，翻译模型，诊断，药物的全球领导者 开发，药理学，公共卫生干预措施以及流行病学和经济建模超过 二十年。 CTR和JHU发出的研究改变了结核病感染的治疗 疾病，阐明结核病和艾滋病毒药物之间的相互作用，证实了新的有效性和有效性 诊断工具，并为全球结核病控制的基于证据的政策做出贡献 结核病的流行病学和人口动态。但是，要在实现结束的努力方面取得进一步的进步 目标，其他创新，跨学科和有影响力的研究至关重要，新一代结核病 必须对科学家进行招募和培训，尤其是在全国范围内与健康有关的团体中 研究（UHRR）。我们已经组建了一个来自多个部门的研究人员的多学科团队 四所JHU学校（医学，公共卫生，护理和工程），具有微生物的完整专业知识 发病机理，免疫学，动物模型，成像，临床试验，诊断，流行病学，药理学和药理学 药物测量学，计算建模和生物统计学，以便为结核病研究提供附加值 JHU的企业优化初级调查人员的培训机会，并支持新的，跨学科的 合作，目的是解决结核病研究中的关键知识差距。 JHU TRAC团队包括 58位研究人员，包括32位经验丰富的结核病研究人员（CTR的19名现任成员），15位高级研究人员 结核病领域的新手和11名早期研究人员（ESI）。 JHU TRAC的总体任务是进步 结核病研究通过促进创新，多学科合作以及招聘，培训和支持 初级研究人员，尤其是在UHRR组中，以发展结核病研究中的下一代领导者。到 这一目的是JHU TRAC将重点放在这四个领域：1）提高JHU的整合，生产力和影响 结核病研究； 2）为下一代研究人员提供心理，支持和试点资金，并为 增加UHRR组的初级研究人员的管道； 3）为结核病研究人员提供直接服务 临床核心和三个科学核心； 4）通过全球参与，培训， 宣传和与高负担国家的合作伙伴合作。 Jhu Trac组织成六个核心 （代理核心（AC）；发育核心（DC）；临床核心（CC）；微生物学，免疫学，动物 建模和成像（迈阿密）核心；药理学和药物计量学核心（PPC）；和生物信息学， 建模和生物统计学核心（BMBC）将彼此紧密相互作用以促进结核病的协同作用 研究，并确保JHU TRAC的效用和产出大于其部分的总和。