Chemistry-Biology Interface Training Grant

化学-生物界面培训补助金

• 批准号: 7881920
• 负责人: LAWRENCE QUE
• 金额: $ 13.95万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7881920
• 关键词: Biology; Chemistry; Grant; Training

See instructions): This pre-doctoral training program at the Chemistry-Biology Interface involves 29 training faculty from three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, and Biochemistry, Molecular Biology and Biophysics (BMBB). It seeks to provide a research training experience to its trainees that crosses the traditional disciplinary boundaries of Chemistry and Biology. Common research themes include: Biocatalysis and Biomolecular Design (Distefano, Kauzlauskus, Lipscomb, Ohlendorf, Schmidt-Dannert, Wackett, Wagner, Wilmot, York), Therapeutic Agents (Amin, Bernlohr, Distefano, Georg, Hoye, Mansky, Sturla, Tretyakova, Wagner, Xing), Chemistry of Disease (Arriaga, Bernlohr, Mansky, Murphy, Sturla, Tretyakova, Wagner, Walters, Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Tolman, Wackett, Wilmot, York), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Taton, Tretyakova, Thomas, Veglia, Walters). The research groups of the training faculty are all well supported and well equipped. There are extensive facilities for peptide and oligonucleotide synthesis, biofermentation, mass spectrometry, X-ray crystallography, NMR, and computation. Support is requested for 8 trainees each year of the program, each to be supported for a two-year period. Prospective trainees will generally have undergraduate degrees in chemistry, biochemistry or oiology. They will be expected to obtain thorough grounding in chemistry, as well as molecular biology and biochemistry. The particular emphasis of this training program is a focus on research problems that address synthetic/mechanistic questions in biological systems, with the goal of understanding and influencing key at the molecular level. The defining characteristic for this training program will be to allow first-rate students to grow into accomplished professionals both in their primary area of interest and in a complementary field. Students will choose from a menu of required coursework in chemistry and biology. In addition, laboratory rotations, a chemical biology colloquium, an annual symposium, journal clubs, and joint group meetings will enrich the graduate experience of the trainees. RELEVANCE (Seeinstructions): The CBITG trainers and their trainees collectively carry out research on fundamental questions related to current important problems in public health. These include understanding how cancers are initiated in the cell, how obesity and diabetes develop and how a muscle works, designing and developing new drugs and assay probes against cancer, HIV, and Alzheimer's disease, and understanding how chemicals are broken down in the environment.

请参阅说明）： 化学生物学界面的该博士前培训计划涉及29个培训教师 来自明尼苏达大学的三个系：化学，药物化学和 生物化学，分子生物学和生物物理学（BMBB）。它试图提供研究培训 向学员的经验，跨越了化学的传统学科界限 生物学。常见研究主题包括：生物催化和生物分子设计（Distefano， Kauzlauskus，Lipscomb，Ohlendorf，Schmidt-Dannert，Wackett，Wagner，Wilmot，York），治疗 特工（Amin，Bernlohr，Distefano，Georg，Hoye，Mansky，Sturla，Tretyakova，Wagner，Xing），Xing）， 疾病的化学（Arriaga，Bernlohr，Mansky，Murphy，Sturla，Tretyakova，Wagner，Walters，Walters， Xing），MetallobioChemistry（Amin，Lipscomb，Murphy，Ohlendorf，Pierre，Que，Que，Tolman，Wackett， Wilmot，York）和生物分析/生物物理（Arriaga，Bowser，Griffin，Haynes，Pierre，Pierre，Taton， Tretyakova，Thomas，Veglia，Walters）。培训教师的研究小组都很好 支持且设备齐全。有广泛的肽和寡核苷酸合成设施， 生物处理，质谱，X射线晶体学，NMR和计算。 计划每年要求8名学员提供支持，每个学员都需要为期两年 时期。准学员通常将拥有化学，生物化学或 生物学。他们将有望在化学和分子中获得彻底的接地 生物学和生物化学。该培训计划的特别重点是专注于研究 解决生物系统中综合/机理问题的问题，目的是 理解和影响分子水平的密钥。该培训的定义特征 计划将允许一流的学生成长为有成就的专业人士 主要感兴趣的领域和互补领域。学生将从所需的菜单中进行选择 化学和生物学课程。此外，实验室旋转，一种化学生物学座谈会， 年度研讨会，期刊俱乐部和联合小组会议将丰富 学员。 相关性（参见Instructions）： CBITG培训师及其受训人员集体就与之相关的基本问题进行了研究 当前的公共卫生重要问题。这些包括了解如何在 细胞，肥胖和糖尿病的发展以及肌肉的工作原理，设计和开发新药以及 测定针对癌症，艾滋病毒和阿尔茨海默氏病的探针，并了解化学物质如何破裂 在环境中。