Early Prevention of Aberrant Behavior in Neurodevelopmental Disorders in Peru

秘鲁神经发育障碍异常行为的早期预防

基本信息

批准号：
7845973
负责人：
STEPHEN ROBERT SCHROEDER
金额：
$ 13.76万
依托单位：
UNIVERSITY OF KANSAS LAWRENCE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7845973
关键词：
Address Adult Age Aggressive behavior Agreement Algorithms American Area Argentina Arts Behavior Behavioral Bolivia Brain Diseases Brazil Caring Certification Cessation of life Chicago Child Child health care Childhood Chronic Client Clinical Cognitive Collaborations Colombia Communities Community Integration Complex Computers Consult Consultations Contracts Country Data Data Storage and Retrieval Databases Dental Dentistry Developing Countries Development Developmental Disabilities Diagnostic Discipline Distance Learning Early identification Early treatment Ecuador Educational process of instructing Educational workshop Environment Environmental Pollution Europe Evaluation Evidence based program Evidence based treatment Experimental Designs Failure Family Feedback Fellowship Fostering Functional disorder Funding Future Genes Genetic Goals Grant Guatemala Hand Health Hour Illinois Indigenous Infant Institutes International Intervention Kansas Latin America Lead Learning Length Letters Life Link Longevity Measures Medical Psychology Medicine Mission Modeling Monitor Neurobiology Neurodevelopmental Disorder Neurologic Neurosciences Nicaragua Occupational Therapy Occupations Pediatrics Peru Philosophy Physical therapy Pilot Projects Play Policies Population Population Study Poverty Prevalence Prevalence Study Prevention Prevention program Preventive Intervention Procedures Province Psychiatry Psychology Psychopharmacology Reading Recording of previous events Recruitment Activity Reporting Research Research Ethics Research Ethics Committees Research Infrastructure Research Personnel Research Project Grants Research Training Resources Rest Risk Risk Factors Role Rotation Sampling Schools Security Self-Injurious Behavior Services Siblings Social Work Socialization Source Spain Special Education Stereotyped Behavior Students Talents Testing Time Toddler Training Training Programs Translating Translations Universities Validation Validity and Reliability Visit Work Writing age group base blind brain behavior cost design evidence base experience high risk human subject improved instrument interest intervention program lectures nutrition policy implication prevent professor programs psychoeducational psychopharmacologic public health relevance research study response socioeconomics stereotypy symposium treatment program

项目摘要

DESCRIPTION (provided by applicant): Aberrant behaviors, i.e. self-injury, aggression, and stereotyped behavior, are some of the most devastating neurodevelopmental disorders (ND). They lead to deteriorating health and, sometimes, early death; they prevent community integration; they impair learning and socialization opportunities; and they are the most salient reason for job failure in the community. They are often linked to several gene-brain-behavior dysfunctions. Prevalence estimates of ND in the U.S., UK, and Europe average c.10% in total population studies. Among all people with ND, prevalence studies in these countries estimate approximately 10-25 % have severe aberrant behaviors, but prevalence is unknown in Latin American countries. Extensive research on behavioral and psychopharmacological treatment and prevention exists, but not in Latin America, where this population is severely underserved. This project aims to study the development and prevention of aberrant behaviors of people with ND in Peru (population 22 million), where only 2% of the population of an estimated 3 million people who have ND are being served. The Centro Ann Sullivan Center del Peru (CASP) is a state-of-the-art school for neurodevelopmental disorders based in Lima, with a network of satellite programs in Peru, Argentina, Brazil, Bolivia, Colombia, Guatemala, Nicaragua, Ecuador, and Spain. CASP has a 27-year history of collaborative sponsorship with the Life Span Institute at the University of Kansas In response to Fogarty PAR-08-113, we propose an R21 to screen 1000 infants and toddlers expecting to find 250 who are at risk for ND, 6-36 mos., 50% of whom are also likely to be at risk for aberrant behaviors (AB) and to follow 100 or more of them plus 100 or more matched controls with ND, but not at risk for AB, at 6- month intervals for 12 months with in-depth interdisciplinary evaluations involving pediatric, psychoeducational, behavioral, neurological, and genetic assessments, to see if they develop aberrant behaviors, as was shown in the U.S. by Berkson, et al.( 2002). The results of this early identification program will be followed by a 5-year R01 on early preventive intervention of aberrant behavior in infants and young children with ND in Lima, Peru. The R21 will also concentrate on building on the existing excellent psycho-educational program and distance learning network at CASP by adding research infrastructure, increasing the research capacity of staff, translation and validation of assessment instruments, and collaborations with appropriate investigators in universities in the U.S., Peru, and other Latin American countries, who will then participate in the subsequent R01. There may be differences in the development of aberrant behavior due to sociocultural practices and health issues, such as uncontrolled environmental pollution, in Latin America. PUBLIC HEALTH RELEVANCE: This project concerns the gene-brain-behavior relationships involved in the development of aberrant behaviors among infants and young children with neurodevelopmental disorders (ND) who live in high-risk environments in Lima, Peru. We plan to develop a risk algorithm that will permit a cost-effective effort at early preventive intervention that can be replicated throughout Latin America, across the CASP distance learning network and beyond, for young children with these extremely debilitating problems.

描述（由申请人提供）：异常行为，即自我伤害，侵略和刻板印象，是一些最具破坏性的神经发育障碍（ND）。它们导致健康状况恶化，有时会导致早期死亡。它们阻止了社区融合；他们损害了学习和社会化机会；它们是社区失业的最显着原因。它们通常与几种基因 - 脑行为功能障碍有关。美国，英国和欧洲ND的患病率估计值为总人口研究的平均水平为10％。在所有有ND的人中，这些国家的患病率研究估计约10-25％的行为严重，但在拉丁美洲国家，患病率尚不清楚。关于行为和心理药理治疗和预防的广泛研究，但在拉丁美洲，该人群严重服务不足。该项目旨在研究秘鲁（2200万人人口）的ND患者的异常行为的发展和预防，其中只有2％的人口估计有300万人被服务于ND。 Centro Ann Sullivan Center del Peru（CASP）是位于利马的神经发育障碍的最先进的学校，该学校位于利马，在秘鲁，阿根廷，巴西，哥伦比亚，哥伦比亚，充巴西，充巴西，充巴西，充巴西，北卡罗来纳州，尼古拉加拉，埃库德尔，埃库德尔和spain建立了卫星计划网络。卡斯普（CASP）与堪萨斯大学的生活跨度研究所合作的历史为期27年，以响应福格蒂（Fogarty）Par-08-113，我们建议将R21提议1000名婴儿和幼儿筛选250名，他们希望找到250名，他们期望有100％的MOS或50％的MOS和50％的人（或者有100个）的风险，以及Abrant Chers。具有ND的对照，但没有AB的风险，以6个月的间隔间隔12个月，深入的跨学科评估涉及小儿，心理教育，行为，神经系统和遗传评估，以查看它们是否发展了异常行为，如Berkson等人所示（2002年）。该早期识别计划的结果将在秘鲁利马的婴儿和幼儿中的异常行为的早期预防性干预中进行5年R01。 R21还将集中于CASP的现有优秀心理教育计划和远程学习网络，通过增加研究基础设施，提高员工的研究能力，翻译和评估工具验证的研究能力，以及与美国，秘鲁大学和其他拉丁美洲国家的适当调查人员合作，他们将参与后续R01。由于社会文化实践和健康问题（例如不受控制的环境污染）在拉丁美洲，异常行为的发展可能存在差异。公共卫生相关性：该项目涉及与居住在秘鲁利马高风险环境中的神经发育障碍（ND）的婴儿和幼儿相比行为形成异常行为的基因 - 行为关系。我们计划开发一种风险算法，该算法将允许在早期预防干预措施中进行具有成本效益的努力，该干预措施可以在整个拉丁美洲，遍布CASP远程学习网络及其他地区，对于具有这些极度令人衰弱的问题的幼儿。