PROTEOMICS AND FUNCTIONA GENOMICS FACILITY

蛋白质组学和功能基因组学设施

• 批准号: 8166252
• 负责人: JAMES W DUMOND
• 金额: $ 7.94万
• 依托单位: TEXAS SOUTHERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-13 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166252
• 关键词: Area; Arsenic; Arts; Blood Pressure; Computer Retrieval of Information on Scientific Projects Database; DNA; DNA Microarray Chip; Development; Doctor of Philosophy; Educational workshop; Equipment; Estrogens; Faculty; Funding; Gene Expression; Genome Stability; Genomics; Goals; Grant; Hand; Housing; Institution; Investigation; Malignant neoplasm of testis; Metals; Microgravity; Molecular; Occupational; Peptides; Pharmacologic Substance; Proteomics; Regulation; Renal function; Research; Research Personnel; Research Project Grants; Research Training; Resources; Role; Science; Simulate; Source; Students; System; Texas; Time; Training; Training Programs; Two-Dimensional Gel Electrophoresis; United States National Institutes of Health; Universities; environmental toxicology; functional genomics; high throughput technology; neurotoxicity; programs; radiation effect; transcription factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Texas Southern University (TSU) is established a Proteomics and Functional Genomics Facility (PFGF). The primary goal of the facility is to serve not only as a core equipment facility, but also as a technological resource for both students and faculty. Currently, there are several funded research projects that directly benefit from this facility. These projects include mechanisms of metal induced neurotoxicity; effect of radiation and simulated microgravity on genomic stability; role of transcription factors and their interactions with endogenous vasoactive factors in regulation of renal function and blood pressure; effect of arsenic on gene expression; role of environmental and occupational estrogens in the development of testicular cancer. While the titles of each of these projects cover a wide range of scientific fields, their commonality comes from the quest to conduct investigations at the molecular level using high throughput technologies. The PFGF supports these and other projects by providing access to state-of-the-art equipment (eg, DNA sequencer, real-time PCR, DNA microarray system, 2-D gel electrophoresis system, and a peptide synthesizer), in addition to providing researchers with technical support. Moreover, the PFGF serves as an excellent educational platform for the MS/PhD program in environmental toxicology and the MS/PhD program in pharmaceutical sciences. The need for this technological advantage in the academic area is critical if TSU is to continue to attract quality scholars to its academic programs. To achieve this goal, the facility supports a graduate research and training program and specialized training sessions, and hands-on workshops. The facility either sponsors or co-sponsors in-house seminars.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 德克萨斯州南部大学（TSU）建立了蛋白质组学和功能基因组学设施（PFGF）。该设施的主要目标不仅是作为核心设备设施，而且是学生和教职员工的技术资源。目前，有几个资金的研究项目直接从该设施中受益。这些项目包括金属诱导的神经毒性的机制；辐射和模拟微重力对基因组稳定性的影响；转录因子的作用及其与内源性血管活性因子的相互作用在肾功能和血压调节中的作用；砷对基因表达的影响；环境和职业雌激素在睾丸癌发展中的作用。尽管这些项目的标题涵盖了广泛的科学领域，但它们的共同点却来自于使用高吞吐量技术在分子级进行调查的追求。 PFGF通过提供对最先进的设备的访问（例如DNA序列，实时PCR，DNA微阵列系统，2-D凝胶电泳系统和肽合成器）来支持这些项目和其他项目，此外还可以为研究人员提供技术支持。 此外，PFGF是MS/PHD环境毒理学和药物科学中MS/PHD计划的出色教育平台。如果TSU要继续吸引优质的学者参加其学术课程，那么在学术领域中对这种技术优势的需求至关重要。为了实现这一目标，该设施支持研究生研究和培训计划以及专门的培训课程以及动手讲习班。该设施发起人或共同发起人内部研讨会。