Sedentary Behaviour Interrupted: Acute, medium and long-term effects on biomarkers of healthy aging, physical function and mortality

久坐行为中断：对健康老龄化、身体功能和死亡率的生物标志物的急性、中期和长期影响

• 批准号: 9278020
• 负责人: Jacqueline Kerr
• 金额: $ 190.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9278020
• 关键词: Accelerometer; Acute; Address; Adopted; Adult; Age; Aging; Algorithms; American Heart Association; Behavior; Behavioral; Biological; Biological Markers; Biostatistics Core; Blood Pressure; Blood flow; Cessation of life; Chronic Disease; Classification; Computational Technique; Cross-Over Trials; Data; Devices; Disease; Dose; Educational workshop; Elderly; Emotional; Energy Metabolism; Ensure; Epidemiology; Female; Goals; Grant; Guidelines; Health; Healthcare; High Prevalence; Hour; Interruption; Intervention; Intervention Studies; Laboratories; Latina; Long-Term Effects; Machine Learning; Measurement; Measures; Metabolic; Methodology; Mitochondria; Movement; Muscle; National Institute on Aging; Outcome; Participant; Patient Self-Report; Pattern; Physical Function; Physical activity; Pilot Projects; Policies; Postmenopause; Posture; Procedures; Prospective Studies; Public Health; Randomized; Recommendation; Research; Research Design; Research Methodology; Resources; Risk; Series; Specific qualifier value; Standardization; Thigh structure; Time; Training; Walking; Woman; Women' s Health; age effect; age group; attentional control; base; behavior observation; blood glucose regulation; cognitive function; design; disability; epidemiology study; evidence base; experience; healthy aging; improved; innovation; mortality; novel; older women; programs; prospective; randomized trial; response biomarker; sedentary; sedentary lifestyle; young adult

Abstract Older adults struggle to engage in health enhancing physical activity (PA) and spend up to 11 hours a day sitting. Older women, in particular, are at increased risk of chronic disease and disability, and use a high proportion of healthcare resources. Improving both these behaviors has promise for improving several salient aging outcomes, but evidence to inform guidelines on how best to interrupt long periods of sedentary behavior (SB) are lacking. Few laboratory-based trials have included adults over 70 years old, have focused on PA to interrupt SB, and have not tested standing breaks that might be acceptable to older adults. A recent review showed that in the real world, traditional PA interventions do not meaningfully impact SB. In contrast, interventions that focus on standing can reduce SB, up to 2 hours per day. Epidemiological studies have shown associations between self-reported SB and increased risks of death and metabolic outcomes, but very few prospective studies have employed objective measures of SB. Although accelerometer measures can indicate the intensity of movement or lack of it, traditional cutpoints do not accurately classify behaviors such as sitting, standing or walking. While pilot intervention studies, using thigh worn inclinometers, have demonstrated that SB can be greatly reduced, there are no RCTs in older adults with health outcomes. There is much room for improvement in our understanding of SB and healthy aging. The National Institute on Aging conducted a summer workshop series to address this issue in 2013. We have therefore designed a Program project – Sedentary Time and Aging Research (STAR) – to provide more rigorous and comprehensive evidence on how to interrupt sitting time and the consequences for healthy aging. In particular, we are proposing a paradigm shift away from energy expenditure as the primary mechanism for health outcomes to investigating behaviors such as brief sit-to-stand transitions that expend little energy but engage muscles, improve postural blood flow, and may impact physical functioning in older adults. Further, we will study a broader range of outcomes than investigated to date, including targeted novel mechanisms important for healthy aging. The STAR program will include 3 Projects and 2 Cores for study of postmenopausal women at risk for chronic disease. STAR includes 2 randomized trials, in the laboratory (N=86) and in the real world (N=592), with focus on optimizing new computational techniques to apply to existing prospective accelerometer data (n>6000). All projects will investigate the consequences of extended sitting, standing, brief sit-to-stand transitions and PA breaks on mechanisms of healthy aging including glucose regulation, endothelial functioning, and mitochondrial functioning. We will also investigate physical functioning, blood pressure and in Project 3, 5-7 year mortality risk. All Projects will compare effects across age groups. STAR will provide a comprehensive evidence base that can inform public health guidelines on SB and aging. We will coordinate our efforts with a new American Heart Association Center on SB and Latinas.

抽象的 老年人难以进行有益于健康的体力活动 (PA)，每天花费长达 11 个小时 尤其是老年女性，患慢性病和残疾的风险更高，并且坐姿较高。 改善这两种行为有望改善几个显着的问题。 衰老结果，但有证据为如何最好地中断长时间久坐行为提供指导 (SB) 很少有基于实验室的试验涉及 70 岁以上的成年人，重点关注 PA 打断 SB，并且尚未测试老年人可能接受的站立休息。 结果表明，在现实世界中，传统的 PA 干预措施不会对 SB 产生有意义的影响。 流行病学研究表明，以站立为重点的干预措施可以减少每天最多 2 小时的 SB。 自我报告的 SB 与死亡和代谢结果风险增加之间存在关联，但非常显着 尽管加速度计测量可以，但很少有前瞻性研究采用 SB 的客观测量。 表明运动的强度或缺乏运动的强度，传统的切点不能准确地对诸如此类的行为进行分类 使用大腿佩戴的倾斜仪进行试点干预研究。 尽管 SB 可以大大减少，但尚无针对老年人健康结果的随机对照试验。 我们对 SB 和健康老龄化的理解还有很大的改进空间。 2013 年举办了一系列夏季研讨会来解决这个问题。因此，我们设计了一个计划 项目 – 二次时间和老化研究 (STAR) – 提供更严格和全面的研究 关于如何中断久坐时间及其对健康衰老的影响的证据尤其如此。 提出范式转变，不再将能量支出作为健康结果的主要机制， 研究诸如短暂的从坐到站的转换等行为，这些行为消耗很少的能量但会调动肌肉， 改善姿势血流量，并可能影响老年人的身体功能。 比迄今为止研究的结果范围更广，包括对以下方面重要的有针对性的新机制 STAR 计划将包括 3 个项目和 2 个核心项目，用于研究绝经后妇女。 STAR 包括 2 项随机试验，分别在实验室 (N=86) 和现实世界中进行。 (N=592)，重点是优化新的计算技术以应用于现有的前景 加速度计数据（n>6000）将调查久坐、站立、短暂的后果。 从坐到站的转变和 PA 破坏了健康衰老的机制，包括葡萄糖调节、 我们还将研究身体功能、血液功能。 压力和项目 3 中的 5-7 年死亡风险将比较不同年龄组的影响。 将提供全面的证据基础，为有关 SB 和老龄化的公共卫生指南提供信息。 与新成立的美国心脏协会 SB 和拉丁裔中心协调我们的工作。