CONNECT-TBI

连接-TBI

• 批准号: 9916354
• 负责人: Douglas Hamilton Smith
• 金额: $ 198.93万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9916354
• 关键词: Acute; Address; Aging; Alzheimer' s Disease; Archives; Attention; Brain; Chronic; Clinical; Clinical Data; Clinical Research; Collaborations; Communities; Complex; Consensus; Data; Data Set; Dementia; Diagnosis; Diagnostic; Enrollment; Exposure to; Future; Health; Human; Injury; Institution; International; Intervention Studies; Late Effects; Lewy Body Disease; Link; Long-Term Survivors; Military Personnel; Nerve Degeneration; Neurodegenerative Disorders; Outcome; Outcome Study; Parkinson Disease; Participant; Pathology; Patients; Phenotype; Prevalence; Process; Prospective Studies; Protocols documentation; Reporting; Research; Research Personnel; Research Support; Resources; Risk; Role; Sampling; Severities; Site; Specimen; Sports; Tissue Donations; Tissue Sample; Tissues; Traumatic Brain Injury; brain research; brain tissue; chronic traumatic encephalopathy; data resource; experience; inhibitor/antagonist; mild traumatic brain injury; multidisciplinary; neuropathology; patient population; programs; prospective; success; tissue resource

OVERALL CONNECT-TBI Program Summary In the past several decades, there has been steadily increasing attention to the neuropathological effects of traumatic brain injury (TBI). Intense media attention has focused on the association of repetitive mild TBI with contact sports and have highlighted the risk of neurodegenerative changes including the widely discussed chronic traumatic encephalopathy (CTE). Unfortunately, little is known about the broader process of TBI- Related Neurodegeneration (TRenD) which encompasses a complex spectrum of pathologies induced by TBI, across all mechanisms and severity levels of injury. Arguably the greatest inhibitor of progress in this field is the limited number of suitable human brain tissue samples and their distribution among disparate research and clinical institutions. To overcome this, the proposed center without walls known as COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI) will be comprised of 26 leading expert investigators in TBI from 12 renowned institutions to generate an unparalleled, comprehensive neuropathological and clinical data resource and conduct a comprehensive research effort into the spectrum of pathologies in all types and severities of TBI. Three Cores – Administrative, Brain Bank, and Data Coordinating – will coordinate and support the collation and examination of over 2800 existing TBI case materials and over 7000 samples from patients with related neurodegenerative disorders. Furthermore, CONNECT-TBI will establish tissue donation protocols for ongoing sample enrollment in the coming years. This resource will be utilized to generate a consensus in the operational criteria for the diagnosis of TReNDs across all range and subtypes and to evaluate the extent and distribution of all neuropathologies resulting from TBI exposure. Furthermore, the center will seek to contrast the phenotypes of TReNDs with that of wider neurodegenerative disease and with aging processes. In all, the CONNECT-TBI collaboration will represent a broad, comprehensive exploration of the intricate neuropathological changes following TBI.

全面的 Connect-TBI程序摘要 在过去的几十年中，人们对神经病理学影响的关注一直稳步 创伤性脑损伤（TBI）。强烈的媒体关注集中在重复的轻度TBI与 联系运动，并强调了神经退行性变化的风险，包括广泛讨论的 慢性创伤性脑病（CTE）。不幸的是，关于TBI的更广泛过程知之甚少 相关的神经变性（趋势），该神经变性（趋势）包括TBI诱导的一系列复杂的病理。 在所有机制和严重程度的伤害水平中。可以说，该领域进步最大的抑制剂是 合适的人脑组织样品数量有限及其在不同的研究中的分布 临床机构。为了克服这一点，提议的中心没有墙壁称为协作 特征TBI结果（连接-TBI）的神经病理网络将完成26个领导 来自12个著名机构的TBI的专家调查员，产生无与伦比的全面 神经病理学和临床数据资源，并进行全面的研究工作 TBI的所有类型和严重性的病理。三个核心 - 行政，脑库和数据协调 - 将协调和支持2800多个现有TBI案例材料及以上的整理和检查 来自相关神经退行性疾病患者的7000个样本。此外，Connect-tbi会 建立组织捐赠方案，用于未来几年的样本注册。这个资源将是 用于在操作标准中建立共识，以诊断所有范围内的趋势 亚型并评估TBI暴露引起的所有神经病理学的程度和分布。 此外，该中心将寻求将趋势的表型与更广泛的神经退行性相比 疾病和衰老过程。总体而言，连接TBI合作将代表广泛的， TBI后，对复杂的神经病理学变化的全面探索。