Consider the influence of injury type and survival interval on cTBI neuropathology

考虑损伤类型和生存间隔对 cTBI 神经病理学的影响

• 批准号: 10024099
• 负责人: Douglas Hamilton Smith
• 金额: $ 9.02万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10024099
• 关键词: Address; Age; Archives; Automobile Driving; Autopsy; Brain; Chronic; Clinical; Complex; Data; Data Set; Dementia; Environmental Risk Factor; Evaluation; Exposure to; Individual; Injury; Knowledge; Lewy body pathology; Link; Methodology; Nature; Nerve Degeneration; Neurocognitive; Neurodegenerative Disorders; Neurologic Dysfunctions; Outcome; Outcome Assessment; Pathology; Patients; Phenotype; Regression Analysis; Research Project Grants; Risk; Severities; Sports; Symptoms; Traumatic Brain Injury; associated symptom; base; comorbidity; dementia risk; design; epidemiologic data; mild traumatic brain injury; neuropathology; neuropsychiatry; programs; sex; tissue resource

Research Project 3 SUMMARY There is growing concern over the association between exposure to traumatic brain injury (TBI) and increased risk of a variety of neuropsychiatric and neurocognitive outcomes, in particular those linked to participation in contact sports. Moreover, compelling epidemiological data indicates severe TBI as an important environmental risk factor for dementia with best current estimates suggesting that between 5 and 15% of all dementia may be TBI related. Both historically and currently, TBI-associated dementia has been presumptively subdivided based on whether it follows a single, moderate or severe TBI or repetitive, mild TBI. However, over the last decade, autopsy studies have revealed complex and overlapping pathologies in individuals across the spectrum of injury exposure. Critically, there is also an incomplete understanding of the extent and distribution of TBI related neurodegeneration (TReND) pathology required to produce neurological dysfunction, the spectrum of symptoms associated with this pathology, or its relationship with wider neurodegenerative disease. As such, there is a pressing need to perform unbiased, comprehensive and robust evaluations of the complete spectrum of TReND pathologies in comparison with patient associated variables and clinical outcomes. We will use comprehensive datasets of the extensive archive of case material from chronic TBI (~850 existing and the predicted additional ~450 new chronic TBI) and matched controls made possible via this CONNECT-TBI Program. Examining these unique tissue resources and linked clinical datasets offers an unrivalled opportunity to link comprehensive outcomes and assessments with neuropathological observations. We propose to 1) examine the influence of injury variables, and 2) Determine the association between neuropathological burden and antemortem clinicopathologic presentation of chronic TBI.

研究项目3 概括 人们对暴露于创伤性脑损伤（TBI）和增加的关联越来越关注 有各种神经精神和神经认知结果的风险，尤其是与参与有关的神经认知结果的风险 联系运动。此外，引人注目的流行病学数据表明严重的TBI是重要的环境 痴呆症的危险因素和最佳当前估计值表明所有痴呆症的5％至15％可能是 TBI相关。从历史上看，目前，TBI相关痴呆都被认为是基于细分的 关于它是遵循单个，中度还是重度TBI还是重复的轻度TBI。但是，在过去的十年中， 尸检研究揭示了跨损伤范围的个体的复杂和重叠的病理 接触。至关重要的是，对与TBI相关的程度和分布也有不完全的理解 产生神经功能障碍所需的神经变性（趋势）病理学，症状的光谱 与这种病理或与更广泛的神经退行性疾病的关系相关。因此，有一个 迫切需要对趋势的完整范围进行公正，全面和强大的评估 与患者相关的变量和临床结果相比，病理学。我们将使用综合 慢性TBI的案例材料的广泛档案数据集（现有〜850，预测的其他 〜450个新的慢性TBI）和匹配的控件通过此连接TBI程序成为可能。检查这些 独特的组织资源和链接的临床数据集为链接全面链接提供了无与伦比的机会 具有神经病理学观察的结果和评估。我们建议1）检查 损伤变量和2）确定神经病理负担与动物质量之间的关联 慢性TBI的临床病理表现。