The Werner Syndrome Protein in DNA Replication, Mutagenesis and Genomic Stability

DNA 复制、诱变和基因组稳定性中的维尔纳综合征蛋白

• 批准号: 7933980
• 负责人: LAWRENCE A LOEB
• 金额: $ 33.58万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7933980
• 关键词: Affect; Age; Aging; Alleles; Atherosclerosis; Bilateral; Binding; Biochemical; Biological Assay; Bypass; Catalysis; Cataract; Cell Aging; Cell physiology; Cells; Childhood; Code; Collaborations; Cultured Cells; DNA; DNA Damage; DNA Structure; DNA biosynthesis; DNA lesion; DNA-Directed DNA Polymerase; Deletion Mutation; Development; Diabetes Mellitus; Disease; Electron Microscopy; Exhibits; Exonuclease; Family; Family Study; Foundations; Frequencies; Future; General Population; Genes; Genetic; Genetic Polymorphism; Genome; Genome Stability; Genomic Instability; Genomics; Gray unit of radiation dose; Hair; High Prevalence; Holoenzymes; Human; Human Genome; Hypersensitivity; Inborn Genetic Diseases; Incidence; Individual; Institutes; Kinetics; Laboratories; Malignant Neoplasms; Measures; Medicine; Mexican; Mexico; Mitotic; Monitor; Mutagenesis; Mutate; Mutation; North Carolina; Osteoporosis; Patients; Persons; Phenotype; Point Mutation; Population; Population Study; Premature aging syndrome; Procedures; Process; Property; Proteins; Public Health; Research; Role; Single Nucleotide Polymorphism; Site; Specificity; Structure; Substrate Specificity; Telomerase; Universities; Washington; Werner Syndrome; Work; adduct; age related; cancer type; exodeoxyribonuclease; helicase; human WRN protein; human disease; member; prevent; quadruplex DNA; recombinational repair; research study; response; synthetic construct; young adult

The proposed experiments will establish a foundation for future studies on the relationship of WRN polymorphisms to age-associated human diseases. These fundamental studies will hasten the pace of research on the relationship of mutations and age-associated diseases and thus are central to medicine and public health. All of the procedures have been established and are ongoing in our laboratory and can be completed within two years.

拟议的实验将为未来研究建立基础 WRN多态性与与年龄相关的人类疾病的关系。这些 基本研究将加快有关突变与年龄相关疾病关系的研究步伐，因此是医学和公共卫生的核心。所有程序均已建立并正在我们的实验室中进行，可以在两年内完成。