OPTICAL ASSESSMENT OF THE EFFECTS OF CHEMOTHERAPY IN BRAIN

脑部化疗效果的光学评估

• 批准号: 8169503
• 负责人: William W. Mantulin
• 金额: $ 0.21万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169503
• 关键词: Address; Adjuvant Chemotherapy; Affect; Anxiety; Area; Attention; Behavior; Blood Vessels; Brain; Breast; Cancer Survivor; Clinical assessments; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Emotional; Emotional Stress; Fatigue; Forehead; Functional Magnetic Resonance Imaging; Funding; Grant; Head; Hemoglobin; Hour; Impairment; Institutes; Institution; Lasers; Long-Term Effects; Mammary Gland Parenchyma; Measures; Memory; Mental Depression; Metabolism; Near-Infrared Spectroscopy; Optics; Participant; Patients; Performance; Performance at work; Pharmaceutical Preparations; Physiology; Psyche structure; Recovery; Recruitment Activity; Regulation; Reporting; Research; Research Personnel; Resources; Rest; Sampling; Schedule; Series; Short-Term Memory; Source; Spectrum Analysis; Staging; Symptoms; System; Techniques; Testing; Time; United States National Institutes of Health; brain metabolism; brain tissue; chemobrain; chemotherapy; density; frontal lobe; hemodynamics; malignant breast neoplasm; optical sensor; oxygen transport; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breast cancer survivor (BCS) patients have reported decline of mental performance after chemotherapy (problems in following every-day schedule, fatigue in keeping-up with previous working performance, depression, anxiety, attention and memory decline), a condition called "Chemobrain". Never the less at routine clinical assessment cognitive compromise is often very subtle. Adjuvant chemotherapy consequences pose a question about subjectively reported and objectively observed symptoms of mental ability decline in BCS. A better understanding of the physiology behind adjuvant chemotherapy in the frontal areas of patients with breast cancer, holds promise to address short and long term effects of circulatory damage in the brain. In this study we will assess the brain hemodynamic behavior of patients with BC. Non-invasive optical techniques offer a tremendous sensitivity to hemoglobin components in breast and brain tissue, and can specifically relate their changes to oxygen transport and exchange impairment: Near infrared spectroscopy (NIRS) and density optical spectroscopy (DOS). The proposed study aims to investigate the neuro-vascular substrate associated with the chemobrain phenomenon in the frontal lobes during rest and during postural tilting in a small sample of BC patients. Subjects will be recruited as a sub-sample of BC patients participating to a larger study on chemotherapy effects on breast tissue, conducted at the UCI-Beckman Laser Institute. A dual optical sensor will be placed on the forehead of each participant and we will measure their neuro-vascular behavior in response to vascular regulation at different medication stages, due to postural tilting. A series of 8 repetitions head-tilt, including recovery time, per subject will require less than an hour acquisition session. Functional magnetic resonance imaging (fMRI) results have supported the hypothesis of lesser brain metabolism at rest in presence of adjuvant chemotherapy, and lesser brain activation in the frontal areas following a memory task. The mechanism behind the abnormal neuro-vascular metabolism in the frontal areas of the brain of BCS patient remains under investigated. Also the memory system is probably not the only one affected by adjuvant chemotherapy; first of all many memory systems exist, secondly strong emotional states interfere with attention. We propose to investigate effects of emotional stress on the attention system using an emotional recognition test (studied words can be nouns with emotional content), with different working memory load level (high vs. low).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 乳腺癌幸存者（BCS）患者报告了化学疗法后的心理表现下降（遵循每天的时间表问题，疲劳，以保持先前的工作表现，抑郁，焦虑，注意力和记忆力下降），这种疾病称为“ Chemobrain”。在常规临床评估认知妥协中，从来都不是很微妙的。 辅助化疗后果提出了一个关于主观报告和客观观察到的BC精神能力症状的问题。更好地了解乳腺癌患者额叶区域辅助化疗背后的生理学，有望解决大脑循环损伤的短期和长期影响。 在这项研究中，我们将评估BC患者的脑血流动力学行为。非侵入性光学技术对乳腺癌和脑组织中的血红蛋白成分具有极大的敏感性，并且可以将它们的变化与氧运输和交换损伤特别相关：近红外光谱（NIRS）和密度光学光谱法（DOS）。 拟议的研究旨在调查与一小部分BC患者样本中的休息期间和姿势倾斜期间与额叶额叶中的化学孔现象相关的神经血管底物。受试者将被招募为卑诗省患者的子样本，该患者参与了在UCI-Beckman Laser Institute进行的有关乳腺组织的化学疗法影响的更大研究。 双重光学传感器将放在每个参与者的额头上，由于姿势倾斜，我们将根据不同药物阶段的血管调节来测量其神经血管行为。每个受试者的恢复时间在内的8个重复倾斜，包括恢复时间，需要少于一个小时的收购会议。 功能性磁共振成像（fMRI）结果支持在存在辅助化疗的情况下，在静止下较小的脑代谢的假设，并且在记忆任务后，额叶区域的大脑激活较小。 BCS患者大脑额叶区域的神经血管代谢异常的机制仍未研究。同样，记忆系统可能不是唯一受辅助化学疗法影响的系统。首先存在许多记忆系统，其次是强烈的情绪状态干扰了注意力。我们建议使用情绪识别测试（研究单词可能是具有情感内容的名词），研究情绪压力对注意力系统的影响，具有不同的工作记忆负载水平（高与低）。