San Francisco Mammography Registry-A Research Source

旧金山乳腺 X 线摄影登记处 - 研究来源

• 批准号: 7912198
• 负责人: KARLA M KERLIKOWSKE
• 金额: $ 24.93万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7912198
• 关键词: Address; African American; Ancillary Study; Area; Asians; Biology; Breast; Breast Cancer Risk Factor; Breast Cancer Surveillance Consortium; California; Cancer Biology; Cancer Center; Case-Control Studies; Cause of Death; Characteristics; Clinical; Community Clinical Oncology Program; Computer Assisted; County; Data; Data Collection; Databases; Development; Diagnostic; Digital Mammography; Enrollment; Epidemiologic Studies; Faculty; Future; Genetic; Geographic Locations; Goals; Habits; Health; Health Services; Healthcare; Hispanics; Image; Imaging technology; Incidence; Intervention; K-Series Research Career Programs; Malignant Neoplasms; Mammography; Medical Surveillance; National Cancer Institute; Nature; Not Hispanic or Latino; Outcome; Pacific Island Americans; Pattern; Performance; Population; Population Heterogeneity; Populations at Risk; Predictive Value; Principal Investigator; Radiology Specialty; Randomized Controlled Trials; Records; Registries; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Assessment; Risk Factors; SEER Program; San Francisco; Screening for cancer; Screening procedure; Source; Students; System; Technology; Testing; Training Programs; Tumor Biology; Ultrasonography; Vital Status; Woman; anticancer research; breast density; cancer diagnosis; cancer risk; clinically significant; cohort; computerized; experience; improved; innovative technologies; interest; malignant breast neoplasm; mammography registry; meetings; member; novel marker; population based; programs; prospective; radiologist; trend

We propose to maintain and expand the population-based, computerized San Francisco Mammography Registry (SFMR) so that it can continue to serve as a resource for conducting high quality, clinically significant research related to breast health and breast cancer. Specifically, we will continue to collect demographic, clinical, and risk factor information, as well as mammography interpretations, cancer outcomes obtained through linkage with the regional population-based Northern California Surveillance, Epidemiology, and End Results (SEER) Program, and cause of death through linkage with the California Department of Health Services Vital Records. The diverse cohort of over 265,000 women that participate in the SFMR includes 47 percent non-Hispanic whites, 33 percent Asian/Pacific Islanders, 5 percent Hispanics, and 8 percent African Americans. Since the registry's inception, information on over 800,000 mammography examinations and 13,000 breast cancers has been collected from 20 facilities in San Francisco and Marin Counties and sent to the Breast Cancer Surveillance Consortium (BCSC) Statistical Coordinating Center. Annually, information is collected on about 111,000 mammography examinations and 1,000 cancers. SFMR data collection provides investigators the opportunity to use robust data, and access to a well characterized population to conduct research. Potential uses of the registry include studies to evaluate: 1) the performance of mammography according to the characteristics of women, radiologist's experience and practice, and tumor biology, 2) associations between risk factors and types of breast cancer, 3) associations between risk factors and breast density, and the biology of breast density, 4) secular trends in breast cancer risk factors, health habits and mammography, 5) quality of breast health care, 6) new markers of risk and rapidly testing their predictive value for breast cancer, and 7) emergent breast imaging technologies. In addition, access to women in the SFMR allows for development of cohorts, enrollment in randomized controlled trials, and conduction of cross-sectional and case-controls studies to examine breast health and health services related issues. The SFMR database provides a valuable resource and rich platform for students, fellows, junior faculty members and other investigators interested in conducting research in the areas of breast imaging, breast health and breast cancer. SFMR investigators will facilitate use of the SFMR and BCSC locally and nationally through several postgraduate training programs at UCSF, presentations at national meetings, and presentations and interactions with members of the Breast Oncology Program at the UCSF Cancer Center.

我们建议维护和扩展基于人群的计算机化旧金山乳房X线摄影注册中心（SFMR），以便它可以继续作为与乳腺癌和乳腺癌有关的高质量，临床上重要的研究的资源。具体而言，我们将继续收集人口统计学，临床和危险因素信息，以及乳房X线摄影解释，通过与基于区域人口的北加州监视，流行病学和最终结果（SEER）计划获得的癌症结局以及通过与加利福尼亚州卫生服务部联系而导致死亡原因（SEER）计划（SEER）。参与SFMR的265,000多名女性组成的队列包括47％的非西班牙裔白人，33％的亚洲/太平洋岛民，5％的西班牙裔和8％的非裔美国人。自登记处成立以来，已经从旧金山和马林县的20个设施中收集了有关800,000多个乳房X线摄影检查和13,000次乳腺癌的信息，并发送到乳腺癌监测财团（BCSC）统计协调中心。每年收集有关大约111,000次乳房X线摄影检查和1,000次癌症的信息。 SFMR数据收集为调查人员提供了使用强大的数据，并访问具有良好特征的人群进行研究的机会。注册表的潜在用途包括评估的研究：1）根据妇女的特征，放射科医生的经验和实践以及肿瘤生物学的表现，2）风险因素与类型的乳腺癌类型之间的关联，3）风险因素与乳房密度与乳房密度之间的关联，以及乳房密度的生物学以及乳腺癌的乳腺癌风险和乳腺癌的快速趋势，乳腺癌的新标志，5），5），5），5）测试其对乳腺癌的预测价值，以及7）新兴的乳房成像技术。此外，在SFMR中与女性的访问允许发展队列，参与随机对照试验的入学以及横断面和病例对照研究的传导，以检查与乳房健康和健康服务相关的问题。 SFMR数据库为学生，研究员，初级教职员工和其他有兴趣在乳房成像，乳腺癌和乳腺癌进行研究的调查人员提供了宝贵的资源和丰富的平台。 SFMR调查人员将通过UCSF的几个研究生培训计划，在全国会议上的演讲以及与UCSF癌症中心的乳房肿瘤学计划的成员进行演讲和互动，在本地和全国范围内促进SFMR和BCSC的使用。