Developing T4 Translational Research Capacity for Control of Hypertension in Rwanda

发展卢旺达控制高血压的 T4 转化研究能力

基本信息

批准号：
9297441
负责人：
Eugene Mutimura
金额：
$ 14.9万
依托单位：
RASD RWANDA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9297441
关键词：
Accreditation Address Adult Africa Africa South of the Sahara Area Atrial Fibrillation Awareness Behavioral Cardiovascular Diseases Caring Cause of Death Cessation of life Chronic Chronic Care Clinical Committee Members Communities Community Healthcare Community Networks Competence Congestive Heart Failure Country Data Data Collection Databases Death Rate Detection Distance Learning Educational Curriculum Educational workshop Effectiveness Evaluation Evidence based intervention Faculty Fostering Generations Goals HIV Health Health Care Research Health Personnel Health Sciences Healthcare Heart High-Income Populations Hypertension Income Intervention Left Ventricular Hypertrophy Malaria Medical Education Medicine Mentorship Modeling Morbidity - disease rate Myocardial Infarction National Heart, Lung, and Blood Institute Needs Assessment Outcome Measure Phase Policies Population Prevalence Prevention Program Sustainability Public Health Research Research Infrastructure Research Training Resource Sharing Resources Risk Factors Rural Rwanda Schools Site Solid Specific qualifier value Structure Sustainable Development Training Training Activity Training Programs Translational Research Tuberculosis Universities Washington Woman base burden of illness cardiovascular risk factor college community setting design disability-adjusted life years dissemination research effective intervention effectiveness research evidence base hypertension control hypertension prevention implementation research improved killings low and middle-income countries low income country men mortality multidisciplinary programs research data dissemination research facility response skill acquisition skills skills training social tool web site

项目摘要

Project Summary In response to RFA-HL-17-003, we propose to create a collaborative team of academics, clinicians, community healthcare providers and public health experts to build in-country capacity to conduct late-stage (T4) translation research (TR) for hypertension (HTN) control in Rwanda. HTN is a major risk factor for cardiovascular disease (CVD), and is the leading cause of death in low-income and middle countries (LMICs), killing more people than HIV, malaria, and tuberculosis combined. HTN accounts for ~10.5 million deaths and 12.8% of total global disability adjusted life years. Pilot data suggest that 36% of Rwandan adults have HTN, and 33% are unaware of their HTN. Rwanda has initiated an HIV model of treatment and care for the management of certain non-communicable diseases (NCDs) at tertiary, provincial and district levels of the healthcare pyramid, and data on HTN/CVD care will be exploited to guide U24 planning, practice and dissemination. Despite emerging evidence for effective behavioral change interventions (from high income countries) on HTN control, there is inadequate information on infrastructure and capacity to engage in T4TR for HTN control in Rwanda. The proposed plan will address these gaps: underutilization and limited interventions to disseminate information and implement HTN awareness campaigns and develop sustainable dissemination and implementation (D&I) research. As proposed, the Regional Alliance for Sustainable Development and the University of Rwanda College of Medicine and Health Sciences (UR- CMHS) have partnered with Washington University in St Louis, MO, USA, amalgamated resources and expertise in T4TR, formed training teams, and will implement skills training through in-country workshops, distance learning/training, and mentorships to develop competencies for D&IR. We will implement T4TR curriculum on competencies retention and post-mentorship for junior Scholars and train UR-CMHS faculty through the Continuous Medical Education (CME) Accreditation program. We will develop and validate qualitative and quantitative tools, conduct desk reviews and carry out needs assessments for HTN chronic care, capacity, facilities, resources and capabilities for T4TR to support implementation of evidence-based interventions to reduce HTN/CVD morbidities. We will foster local and US partnerships, including Faith- based and non-governmental organizations and grassroots community-level partners, and leverage resources with existing training programs for sustainable and independent T4TR capacity. We will prioritize intervention areas, develop a research plan, and disseminate findings through community networks, websites, healthcare forums and resource-sharing databases to guide policy and practice. We will collaborate with Steering Committee members to evaluate program progress based on concrete specific aims, milestones and outcome measures. This plan will establish the required network and capacity to propose and conduct high impact T4TR on HTN control and substantially impact public health in Rwanda.

项目概要为了回应 RFA-HL-17-003，我们建议创建一个由学者、临床医生、社区医疗保健提供者和公共卫生专家建立国内进行后期阶段的能力 (T4) 卢旺达高血压 (HTN) 控制转化研究 (TR)。 HTN 是主要危险因素心血管疾病（CVD），是低收入和中等国家死亡的主要原因（中低收入国家），造成的死亡人数比艾滋病毒、疟疾和结核病的总和还多。 HTN 约 1050 万死亡人数和全球残疾调整生命年总数的 12.8%。试点数据表明，36% 的卢旺达人成年人患有高血压，33% 的人不知道自己患有高血压。卢旺达启动了艾滋病毒治疗模式为高等教育、省级和地区某些非传染性疾病 (NCD) 的管理提供护理医疗保健金字塔的各个层次，以及 HTN/CVD 护理数据将被用来指导 U24 规划，实践和传播。尽管有新的证据表明有效的行为改变干预措施（来自高收入国家）关于 HTN 控制的基础设施和能力信息不足在卢旺达参与 T4TR 控制 HTN。拟议的计划将解决这些差距：利用率不足传播信息和开展高血压意识宣传活动的干预措施有限，开展可持续传播和实施（D＆I）研究。根据提议，区域联盟可持续发展和卢旺达大学医学与健康科学学院 (UR- CMHS）与美国密苏里州圣路易斯华盛顿大学合作，合并资源并 T4TR方面的专业知识，组建培训团队，并将通过国内研讨会实施技能培训，远程学习/培训和指导，以培养 D&IR 能力。我们将实施T4TR 为初级学者提供能力保留和后期辅导课程，并培训 UR-CMHS 教师通过持续医学教育 (CME) 认证计划。我们将开发并验证定性和定量工具，进行案头审查并进行慢性高血压的需求评估 T4TR 支持实施基于证据的护理、能力、设施、资源和能力减少 HTN/CVD 发病率的干预措施。我们将促进当地和美国的合作伙伴关系，包括信仰- 基层组织和非政府组织以及基层社区合作伙伴，并发挥杠杆作用现有培训计划的资源，以实现可持续和独立的 T4TR 能力。我们将优先考虑干预领域，制定研究计划，并通过社区网络传播研究结果，网站、医疗保健论坛和资源共享数据库来指导政策和实践。我们将与指导委员会成员合作，根据具体具体情况评估项目进展情况目标、里程碑和成果衡量标准。该计划将建立所需的网络和能力提议并实施对 HTN 控制具有重大影响的 T4TR，并对卢旺达的公共卫生产生重大影响。