Human Tissue Aquisition and Pathology Shared Resource

人体组织采集和病理学共享资源

• 批准号: 8733543
• 负责人: MARY M. ZUTTER
• 金额: $ 30.11万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8733543
• 关键词: Anatomy; Autopsy; Biochemical; Biopsy; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cell Adhesion Molecules; Clinical; Clinical Pathology; Clinical Trials; Collection; Disease; Doctor of Medicine; Ensure; Equipment; Excision; Freezing; Funding; Goals; Grant; Hematopathology; Histology; Human; Image Analysis; Laboratory Research; Lasers; Malignant Neoplasms; Microscopy; Molecular; Operative Surgical Procedures; Pathology; Peer Review; Process; Quality Control; Research; Research Personnel; Resource Sharing; Resources; Role; Services; Specimen; Tissue Microarray; Tissue Sample; Tissues; United States National Institutes of Health; Work; anticancer research; experience; host neoplasm interaction; human tissue; neoplastic; operation; pre-clinical; professor; research study; tissue fixing

The goal of the Human Tissue Acquisition and Pathology Shared Resource (HTAP) is to provide human tissue samples and histology services to support translafional and preclinical aspects of cancer research. This resource has been in operation since 1993; at the last competitive renewal, this shared resource received an "Outstanding" rating. HTAP provides researchers with access to a wide variety of human specimens and fissues. HTAP's objectives are to collect, process, bank, and distribute remnant human tissues (both normal and neoplastic) from routine surgical resections and autopsies for use by peer-reviewed and funded Vanderbilt-lngram Cancer Center (VICC) investigators in basic, clinical, and translafional research studies. This includes providing the highest quality, well-characterized fresh, frozen, and fixed tissues suitable for a wide range of molecular, biochemical, and tissue analyses. HTAP will also assist with the collection and banking of biopsy material for specific cancer-related clinical trials and other projects and will perform quality control to ensure that the relevant tissue is supplied to the researcher, and that fissues are suitable for the planned research (e.g., not necrofic or involved by unsuspected disease processes). HTAP is well situated in regards to space and equipment. Services highly utilized by VICC investigators and only provided by HTAP include laser capture microscopy, tissue array construction and image analysis. This shared resource is of critical importance for the translational work of VICC invesfigators. Mary Zutter, M.D., Professor of Pathology and Cancer Biology and Ingram Professor of Cancer Research, became scientific director in May 2009. Dr. Zutter directs a research laboratory that focuses on the role of cell adhesion molecules in host-tumor interactions. She has been funded continuously by the NIH for the past 17 years and is currently supported by three R01 grants from the NCI. In addition, she is board certified in Anatomic and Clinical Pathology and directs the Division of Hematopathology. She is assisted by a staff with decades of experience and by the Informafics Shared Resource, under the direction of Dan Masys, M.D.

人体组织采集和病理学共享资源 (HTAP) 的目标是为人类提供 组织样本和组织学服务，支持癌症研究的转化和临床前方面。 该资源自 1993 年开始运行；在上次竞争性更新时，此共享资源 获得“优秀”评级。 HTAP 为研究人员提供了接触各种人类 标本和组织。 HTAP 的目标是收集、处理、储存和分发剩余人类 来自常规手术切除和尸检的组织（正常和肿瘤）供同行评审使用 并资助范德比尔特-英格拉姆癌症中心 (VICC) 的基础、临床和转化研究人员 研究。这包括提供最高品质、特性良好的新鲜、冷冻和固定产品 适用于广泛的分子、生化和组织分析的组织。 HTAP 还将协助 为特定癌症相关临床试验和其他项目收集和储存活检材料，以及 将进行质量控制，以确保向研究人员提供相关组织，并且组织 适合计划的研究（例如，不坏死或涉及意外的疾病过程）。 HTAP 在空间和设备方面都处于有利位置。 VICC 调查人员高度利用的服务 仅由 HTAP 提供的包括激光捕获显微镜、组织阵列构建和图像分析。这 共享资源对于 VICC 调查人员的转化工作至关重要。 Mary Zutter，医学博士，病理学和癌症生物学教授兼英格拉姆癌症教授 研究，于 2009 年 5 月成为科学总监。Zutter 博士领导一个研究实验室，专注于 细胞粘附分子在宿主-肿瘤相互作用中的作用。她一直受到 NIH 的资助 过去 17 年，目前得到 NCI 的三项 R01 资助的支持。此外，她还是董事会成员 获得解剖学和临床病理学认证，并领导血液病理学部门。她的协助者是 拥有数十年经验的员工，在 Dan 的指导下，通过信息学共享资源 马西斯医学博士