Mexican Chronic Renal Insufficiency Cohort Study

墨西哥慢性肾功能不全队列研究

基本信息

批准号：
8720829
负责人：
JAMES P. LASH
金额：
$ 5.15万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-20 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8720829
关键词：
Anemia due to Chronic Disorder Award Blood Pressure Bone Diseases Cardiovascular Diseases Cardiovascular system Cause of Death Chicago Chronic Kidney Failure Chronic Kidney Insufficiency Cities Clinical Cohort Studies Collaborations Country Data Dialysis procedure Disease Progression Education End stage renal failure Enrollment Epidemiology Event Extramural Activities Funding Future Glucose Goals Health Health Services Accessibility Health behavior Hispanics Hospital Mortality Illinois Income Inflammation Institution International Kidney Diseases Kidney Failure Kidney Transplantation Knowledge Life Lipids Mental Depression Metabolic Bone Diseases Metabolism Mexican Mexico Minerals Mission National Institute of Diabetes and Digestive and Kidney Diseases Not Hispanic or Latino Outcome Participant Patients Prevalence Principal Investigator Proteinuria Public Health Public Health Schools Quality of life Recruitment Activity Renal function Research Research Infrastructure Research Methodology Research Personnel Resources Risk Factors Smoking Social support Training United States National Institutes of Health Universities base cardiovascular risk factor cohort design disorder control follow-up functional status health literacy improved patient oriented programs public health relevance

项目摘要

DESCRIPTION (provided by investigator): The proposed Mexican Chronic Renal Insufficiency Cohort Study is collaboration between a U.S. based NIH- funded investigator, James P. Lash, MD and Magdalena Madero, MD, a nephrologist at the Instituto Nacional de Cardiologia Ignacio Chavez in Mexico City. In Mexico, chronic kidney disease (CKD) represents a growing public health problem, with an increase in prevalence of 11% per year in the last 10 years. Furthermore, CKD is the third most common cause of in-hospital mortality in Mexico. Despite the magnitude of this problem, little is known about the epidemiology of CKD in Mexico. A better understanding of risk factors for progression of CKD is of critical importance because less than one-half of patients with kidney failure in Mexico have access to dialysis or kidney transplantation. The overall objective of this application is to recruit and retain a cohort of 340 Mexicans with mild-to-moderate CKD. Preliminary data generated during the period of support will be utilized to apply for extramural funding to extend participant follow-up in order to accomplish the following long- term Specific Aims: 1) Identify risk factors for progression of kidney disease in Mexicans with CKD; 2) Identify risk factors for cardiovascular events and progression of subclinical cardiovascular disease; 3) Evaluate the association between CKD and other clinical outcomes such as functional status, quality of life, and depression; and 4) Compare rates of CKD progression between Mexicans with CKD living in Mexico and Mexicans with CKD living in the U.S. The proposed study will leverage the infrastructure of an active NIDDK-funded research program which is focused on investigating the epidemiology of CKD in U.S. Hispanics and non-Hispanics (Principal Investigator Lash, R01 DK72231, and U01 DK60980) and the extensive training resources available at the University of Illinois at Chicago School of Public Health. This application fulfills the mission of the Fogarty International Research Collaboration Award program by building epidemiologic CKD research capabilities in Mexico and providing training in research methodology for Dr. Madero and other trainees at her institution. Furthermore, the knowledge gained by the research has the potential to inform the design of future interventional trials with the goal of improving health outcomes for Mexicans with CKD.

描述（由研究者提供）：拟议的墨西哥慢性肾功能不全队列研究是美国 NIH 资助的研究者 James P. Lash（医学博士）和 Magdalena Madero（医学博士）（墨西哥国家心脏病研究所 Ignacio Chavez 的肾脏病专家）之间的合作城市。在墨西哥，慢性肾病 (CKD) 是一个日益严重的公共卫生问题，过去 10 年患病率每年增加 11%。此外，慢性肾病是墨西哥院内死亡的第三大常见原因。尽管这个问题很严重，但人们对墨西哥 CKD 的流行病学知之甚少。更好地了解 CKD 进展的危险因素至关重要，因为墨西哥只有不到一半的肾衰竭患者能够接受透析或肾移植。该申请的总体目标是招募并留住 340 名员工患有轻度至中度慢性肾病的墨西哥人。支持期间产生的初步数据将用于申请外部资金，以延长参与者的随访，以实现以下长期具体目标： 1) 确定患有 CKD 的墨西哥人肾病进展的危险因素； 2）识别心血管事件和亚临床心血管疾病进展的危险因素； 3) 评估 CKD 与其他临床结果（如功能状态、生活质量和抑郁）之间的关联； 4) 比较居住在墨西哥患有 CKD 的墨西哥人和居住在美国患有 CKD 的墨西哥人之间的 CKD 进展率。拟议的研究将利用 NIDDK 资助的一项活跃研究项目的基础设施，该项目的重点是调查美国西班牙裔中 CKD 的流行病学和非西班牙裔（首席研究员 Lash、R01 DK72231 和 U01 DK60980）以及伊利诺伊大学芝加哥公共卫生学院提供的广泛培训资源。该应用程序通过在墨西哥建立流行病学 CKD 研究能力并为 Madero 博士及其机构的其他学员提供研究方法培训，履行了福格蒂国际研究合作奖计划的使命。此外，通过研究获得的知识有可能为未来干预试验的设计提供信息，以改善患有 CKD 的墨西哥人的健康结果。