The Wake Forest Center for Botanical Lipids and Inflammatory Disease Prevention

维克森林植物脂质和炎症疾病预防中心

基本信息

批准号：
8330548
负责人：
FLOYD H CHILTON
金额：
$ 6.07万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-04-01 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8330548
关键词：
11q12-q13 Acids Address Adult Affect African American Alleles American Anthropology Anti-Inflammatory Agents Anti-inflammatory Arachidonate 5-Lipoxygenase Area Asthma Atherosclerosis Back Biochemical Biodiversity Biological Biological Factors Biological Markers Biological Preservation Biometry Blood Borago Botanicals Botany Carbon Cardiovascular Diseases Caucasians Caucasoid Race Cell Differentiation process Cells Characteristics Cholesterol Chromosomes Chromosomes, Human, Pair 11 Clinical Immunology Clinical Research Clinical Trials Design Coenzyme A Collaborations Complement Complementary and alternative medicine Complex Consultations DNA Data Databases Diabetes Mellitus Dietary Fats Disease Distal Doctor of Philosophy Echium Effectiveness Eicosanoid Production Eicosanoids Ensure Enzymes Epidemiologist Epoxy Compounds Extrinsic asthma Fatty Acid Desaturases Fatty Acids Fee-for-Service Plans Flax Frequencies Funding Gas Chromatography Gene Cluster Gene Expression Gene Expression Regulation Gene Family Generations Genes Genetic Genetic Polymorphism Genetic Transcription Genetic Variation Genomics Genotype Goals Grant Health Health Sciences Human Human Resources Hypersensitivity Immunity Immunogenetics Individual Inflammation Inflammation Mediators Inflammatory Inflammatory Response Influentials Institutes Internal Medicine International Investigation Island Knockout Mice Laboratories Lead Leadership Leukocyte Trafficking Leukocytes Leukotriene C4 Leukotriene D4 Leukotriene E4 Leukotriene Production Leukotrienes Ligase Link Linseed Oil Lipids Low Density Lipoprotein Receptor Maps Mass Spectrum Analysis Mediator of activation protein Medicinal Plants Medicine Metabolic Metabolic syndrome Metabolism Minor Minority Modality Modeling Molecular Monitoring Clinical Trials Mononuclear Mus Nonesterified Fatty Acids Oils Olive oil preparation Olives - dietary Pathway interactions Patients Phenotype Phospholipase A2 Phospholipids Physicians Plant Oils Plant Sources Plants Play Population Positioning Attribute Prevention Preventive Principal Investigator Process Production Prostaglandins Public Health Publishing Race Relative (related person)Research Research Personnel Research Project Grants Resources Role Running Sampling Science Screening procedure Seeds Serum Signal Transduction Site Skiing Source Supplementation TNFRSF5 gene Techniques Testing Thromboxanes Training Transactivation Transduction Gene Triglycerides United States National Institutes of Health Universities Unsaturated Fatty Acids Variant Work arm base borage oil cytokine desaturase design dietary supplements disorder prevention epidemiology study ethnic difference experience fatty acid metabolism forest genetic analysis genetic epidemiology granulocyte in vivo indexing instrumentation interest lipid metabolism liquid chromatography mass spectrometry macrophage mast cell medical schools member monocyte novel peripheral blood prevent professor programs public health relevance quality assurance research study response trafficking transcription factor

项目摘要

DESCRIPTION (provided by applicant): The Center for Botanical Lipids and Inflammatory Disease Prevention is a new version of a P50 at Wake Forest University Health Sciences that has been continuously funded since 2005. Research over the past 50 years has shown that both systemic and localized inflammation play an important role in the onset and progression of destructive diseases such as cardiovascular disease, metabolic syndrome/diabetes and allergic asthma. The overall goal of this Center is to delineate the molecular mechanisms by which botanical oils prevent or impact these diseases with a particular focus on immunity and inflammation. The central hypothesis of the Center is that medium chain poly-unsaturated fatty acids (PUFAs) in botanical oils and their metabolites impact several key mechanisms (including altering pro-and anti-inflammatory mediator production and blocking inflammatory gene expression) that inhibit inflammatory processes. A secondary hypothesis is that that the metabolism and effectiveness of PUFA-based botanical dietary supplements is strongly associated with genetic polymorphisms in the fatty acid desaturase (FADS 1-3) cluster on chromosome 11 in a region known as 11q12-q13. This chromosomal region has repeatedly been linked to pro-inflammatory conditions. This Center brings together investigators from five internationally-recognized lipid groups and a world-renowned human genomics center to examine cellular and molecular mechanisms by which PUFAs within botanical oils impact human health. Selected botanical oils and combinations (including olive, flax seed, borage seed and echium seed oils) found in supplements are used to test key hypotheses. Projects 1 and 2 examine the mechanisms leading to the pleiotropic effects of botanical PUFAs on macrophage/ monocyte activation, inflammatory states and eicosanoid generation related to atherosclerosis and asthmatic inflammation, respectively. Project 3 examines the critical role genetic variations in the FADS cluster plays in determining PUFA levels and investigates how specific variations in that cluster are associated with the effectiveness of PUFA-based botanicals supplements in metabolic syndrome/diabetes. The interactive and synergistic Projects and Cores have a strong, contemporary and translational scientific basis and should allow this scientific team to identify additional mechanisms and identify human individuals and populations that are most likely to be affected by PUFA- based botanical supplements. PUBLIC HEALTH RELEVANCE: Thirty-eight percent of adult Americans are using complementary and alternative medicine modalities. The most commonly used modalities are natural products enriched with PUFAs (37 % of natural products). The key purpose of this Center is determine the molecular mechanisms by which medium chain PUFAs in botanical oils prevent of complex diseases such as CVD, asthma or metabolic syndrome and to determine the populations where they are most likely to be effective.

描述（由申请人提供）：植物脂质和炎症疾病预防中心是维克森林大学健康科学中心 P50 的新版本，自 2005 年以来一直持续资助。过去 50 年的研究表明，系统性和局部性炎症在心血管疾病、代谢综合征/糖尿病和过敏性哮喘等破坏性疾病的发生和进展中发挥着重要作用。该中心的总体目标是描绘植物油预防或影响这些疾病的分子机制，特别关注免疫和炎症。该中心的核心假设是植物油中的中链多不饱和脂肪酸（PUFA）及其代谢物影响抑制炎症过程的几个关键机制（包括改变促炎和抗炎介质的产生以及阻断炎症基因表达）。第二个假设是，基于 PUFA 的植物膳食补充剂的代谢和有效性与 11 号染色体 11q12-q13 区域的脂肪酸去饱和酶 (FADS 1-3) 簇的遗传多态性密切相关。该染色体区域已多次与促炎性疾病相关。该中心汇集了来自五个国际公认的脂质组和一个世界著名的人类基因组中心的研究人员，研究植物油中的多不饱和脂肪酸影响人类健康的细胞和分子机制。补充剂中的精选植物油和组合（包括橄榄油、亚麻籽油、琉璃苣籽油和蓝蓟籽油）用于测试关键假设。项目 1 和 2 研究了植物性 PUFA 分别对与动脉粥样硬化和哮喘炎症相关的巨噬细胞/单核细胞活化、炎症状态和类二十烷酸生成产生多效作用的机制。项目 3 检查 FADS 簇中的遗传变异在确定 PUFA 水平方面所起的关键作用，并研究该簇中的特定变异如何与基于 PUFA 的植物补充剂在代谢综合征/糖尿病中的有效性相关。互动和协同的项目和核心具有强大的、当代的和转化性的科学基础，应该使这个科学团队能够确定额外的机制，并确定最有可能受到基于多不饱和脂肪酸的植物补充剂影响的人类个体和人群。公共卫生相关性：38% 的美国成年人正在使用补充和替代医学方式。最常用的方式是富含 PUFA 的天然产品（占天然产品的 37%）。该中心的主要目的是确定植物油中的中链多不饱和脂肪酸预防心血管疾病、哮喘或代谢综合征等复杂疾病的分子机制，并确定它们最有可能有效的人群。