The Botanical and Quality Assurance Core/Susan Sergeant

植物学和质量保证核心/Susan Sergeant

• 批准号: 8007057
• 负责人: FLOYD H CHILTON
• 金额: $ 12.9万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8007057
• 关键词: Address; Animals; Archives; Botanicals; Botany; Chemicals; Chronic; Collection; DNA; Detection; Development; Dietary Oils; Disease; Documentation; Ensure; Equipment and supply inventories; Evaluation; Fatty Acids; Future; Goals; Heavy Metals; Human; Inflammatory; Lipids; Medicinal Plants; Microbe; Oils; Organism; Outcome; Pesticides; Plant Sources; Plant alkaloid; Plants; Population; Preparation; Procedures; Process; Protocols documentation; Quality Control; Records; Recurrence; Reporting; Reproducibility; Research; Research Personnel; Safety; Sampling; Services; Source; Testing; Vendor; arm; base; forest; novel; quality assurance; stearidonic acid; voucher

The use of high quality botanicals is essentia! in understanding their beneficial effects and the mechanism(s) of action of their bioactive components as well as for ensuring reproducibility of experimental results. High quality botanicals are those that are standardized plant materials of known provenance. Due to high variability of bioactivity and chemical concentrations found in various populations of similar plant species, high quality, consistent botanicals for study are difficult to identify. The Botany and Quality Assurance Core (Core B) will primarily function as a centralized quaility control unit for the Center to address these complicated issues. Two Specifc Aims will be implemented to achieve this primary function. Core B will assess botanical suppliers and their products, evaluate product documentation, confirm identity collections of plant-derived material and acquire the botanical oils to be used for all Center Projects (Aim 1). Additionally Core B will evaluate bioactive components (content and long term stability) and assess potential contaminants (Aim 2). Collectively, these proposed activites are expected to ensure the safety of botanicals used in Center Projects as well as the reproducibility of experimental outcomes with these botanicals. The analytical and taxonomic strengths of Core B will also be utilized for a secondary function (Aim 3). Core B will attempt to identify alternative land and aquatic botanical organisms that may be useful for future development as a source of botanical oil. The ideal organism (s) would offer a fatty acid profile and content potentially superior to those currently in use. The functions of the Botanical and Quality Assurance Core (Core B) are expected facilitate the use of high quality botanical oils by the Center Projects.

使用高品质植物成分是关键！了解它们的有益作用和机制 其生物活性成分的作用以及确保实验结果的可重复性。高的 优质植物药是那些已知来源的标准化植物材料。由于高 在相似植物物种的不同种群中发现的生物活性和化学浓度的变异性， 用于研究的高质量、一致的植物成分很难识别。植物学和质量保证核心 （核心 B）将主要充当中心的集中质量控制单位，以解决这些问题 复杂的问题。为了实现这一主要功能，将实施两个具体目标。核心B将 评估植物供应商及其产品，评估产品文档，确认身份收集 植物源材料并获取用于所有中心项目的植物油（目标 1）。 此外，核心 B 将评估生物活性成分（含量和长期稳定性）并评估潜力 污染物（目标 2）。总的来说，这些拟议的活动预计将确保植物药的安全 中心项目中使用的以及这些植物的实验结果的可重复性。 核心 B 的分析和分类优势也将用于次要功能（目标 3）。核 B 将尝试找出可能对未来有用的替代陆地和水生植物生物体 开发作为植物油的来源。理想的生物体将提供脂肪酸谱和含量 可能优于目前使用的那些。 植物和质量保证核心（核心 B）的功能预计将促进高水平的使用 中心项目提供优质植物油。