Gene Transfer Training Core

基因转移培训核心

• 批准号: 7688330
• 负责人: JOHN C OLSEN
• 金额: --
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688330
• 关键词: Admission activity; Animal Experimentation; Basic Science; Biology; Biotechnology; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical and Translational Science Awards; Comprehensive Cancer Center; Computer Systems; Data Collection; Disease; Doctor of Medicine; Doctor of Philosophy; Educational Curriculum; Educational process of instructing; Ethicists; Ethics; Evaluation; Foundations; Funding; Gene Transfer; Genetic; Goals; Hemostatic function; Housing; Human; Individual; Inherited; Institutes; Interdisciplinary Study; Laboratories; Medicine; Mentors; Methods; Molecular; Molecular Biology; Neurosciences; North Carolina; Nurses; Patients' Rooms; Pharmacology; Principal Investigator; Process; Production; Protocols documentation; Pulmonary Cystic Fibrosis; Recombinants; Research; Research Ethics; Research Ethics Committees; Research Training; Resources; Safety; Scientist; Series; Source; Specimen; Structure; Students; Technology; Thrombosis; Training; Training Programs; Training Support; Translating; Translational Research; Universities; base; career; design; experience; gene therapy; gene transfer vector; graduate student; human subject; interest; medical schools; meetings; post-doctoral training; programs; skills; social; theories; treatment center; vector

Institutional resources for training. The School of Medicine at the University of North Carolina at Chapel Hill has many resources that support the training of individuals in translational research. It offers a four-year curriculum for more than 160 entering students pursuing the M.D. degree and also offers admission to twelve M.D/Ph.D. entering students annually. Graduate doctoral programs (Ph.D.) are offered in all the basic sciences departments, as are vigorous post-doctoral training programs in both the basic science and clinical departments. Of note, UNC is blessed with a host of multidisciplinary research centers, institutes, and programs, which promote interactions between basic scientists and clinicians. This combination of departmental and research center based programs has been responsible for the training of a large number of individuals in both the basic sciences and clinical investigation over the years. Currently, 46 NIH-sponsored training programs are active on the School of Medicine campus. An additional ten training programs are funded by non-NIH sources including the prestigious Markey Training Program which is jointly supported by the State of North Carolina and the Markey Foundation to provide graduate student stipends for students training in the Genetics Curriculum who wish to train in gene therapy. Many of these centers and programs are attractive for the recruitment of individuals interested in translational gene transfer research. Key centers and programs relevant to our efforts include the Caviness General Clinical Research Center (GCRC), the Cystic Fibrosis/Pulmonary Research and Treatment Center, the Gene Therapy Center, the M.D./Ph.D. program, the Center for Thrombosis and Hemostasis, the Lineberger Comprehensive Cancer Center, the Neuroscience Center, the Curriculum in Genetics and Molecular Biology, and the Program in Molecular Biology and Biotechnology. The Cystic Fibrosis/Pulmonary Research and Treatment Center and the Gene Therapy Center each have active training programs that would be enhanced by this MTCC application. A list of current trainees for these two centers is included in Table 1. The Caviness General Clinical Research Center (GCRC) is of special importance to trainees interested in translational research. This NIH-funded center is directed by Dr. Paul B. Watkins and houses six patient rooms designed for gene therapy protocols employing recombinant gene transfer vectors. Significant support is available to trainees through the GCRC including a biostatistician and computer systems analyst to assist with data collection and analysis, nursing support for clinical trials, an office of clinical trials for assistance with protocol design and institutional review board (IRB) review, a core laboratory for processing of routine human laboratory specimens from clinical trials, and a human applications laboratory for processing of molecular specimens from human trials and ultimately vector production. Although not yet official, we anticipate that the GCRC will transition into a Clinical and Translational Science Award (CTSA) in this budgetary year.

培训机构资源。北卡罗来纳大学医学院 教堂山分校拥有许多支持转化研究个人培训的资源。它 为 160 多名攻读医学博士学位的新生提供四年制课程， 提供十二名医学博士/博士学位的录取机会每年入学的学生。研究生博士课程（Ph.D.） 所有基础科学系均提供博士后培训项目 基础科学和临床部门。值得注意的是，北卡罗来纳大学拥有众多多学科的人才 研究中心、研究所和项目，促进基础科学家和研究人员之间的互动 临床医生。这种以部门和研究中心为基础的项目的结合负责 为大量基础科学和临床研究人员提供培训 这些年。目前，医学院校园内正在开展 46 个 NIH 资助的培训项目。 另外十个培训项目由非 NIH 来源资助，包括著名的 Markey 培训计划由北卡罗来纳州和马基基金会联合支持 为希望接受遗传学课程培训的学生提供研究生津贴 基因疗法。许多这些中心和项目对于招聘个人来说很有吸引力 对转化基因转移研究感兴趣。与我们的努力相关的关键中心和项目 包括 Caviness 一般临床研究中心 (GCRC)、囊性纤维化/肺 研究和治疗中心、基因治疗中心、医学博士/博士。计划，中心 血栓和止血、Lineberger 综合癌症中心、神经科学中心、 遗传学和分子生物学课程以及分子生物学和分子生物学项目 生物技术。囊性纤维化/肺部研究和治疗中心及基因治疗 每个中心都有积极的培训计划，该 MTCC 应用程序将增强这些计划。清单 这两个中心目前的受训人员列于表 1 中。 卡维尼斯综合临床研究中心 (GCRC) 对学员来说特别重要 对转化研究感兴趣。该中心由 NIH 资助，由 Paul B. Watkins 博士领导， 设有六间专为采用重组基因转移的基因治疗方案而设计的病房 向量。通过 GCRC 为学员提供重要支持，包括生物统计学家和 计算机系统分析师协助数据收集和分析、临床试验护理支持、 临床试验办公室协助方案设计和机构审查委员会 (IRB) 审查， 处理来自临床试验的常规人类实验室样本的核心实验室，以及一个人类 应用实验室用于处理人体试验的分子样本并最终矢量 生产。尽管尚未正式发布，但我们预计 GCRC 将转变为临床和 本预算年度的转化科学奖（CTSA）。