CANCER CONTROL RESEARCH PROGRAM

癌症控制研究计划

基本信息

批准号：
7944592
负责人：
JAMES D. SARGENT
金额：
$ 7.55万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-21 至 2013-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7944592
关键词：
Accounting Adolescent Adoption Adverse effects Alleles Apolipoprotein E Area Behavior Cancer Center Support Grant Cancer Control Cancer Control Research Program Cancer Patient Cancer Survivor Collaborations Communication Communication Research Communities Complication Continuity of Patient Care Development Diagnosis Doctor of Philosophy Early Diagnosis Ensure Exposure to Fostering Funding Goals Health Campaign Health Services Research Individual Joints Lead Mammography Manuscripts Mentorship Mission Patients Peer Review Pharmaceutical Preparations Policies Prevention Primary Health Care Public Health Publications Publishing Quality of Care Quality of life Research Research Personnel Resources Risk Behaviors Risk Reduction Screening for cancer Screening procedure Smoke Smoking Structure The Sun Training Programs Translating Translations Work adolescent smoking base cancer care cancer risk cancer therapy care systems cognitive function dissemination research health care delivery high risk improved mammography registry meetings member mortality movie novel programs successful intervention

项目摘要

The mission of the Cancer Control Program is to promote collaborative research to reduce cancer risk and mortality and to enhance the quality of life of cancer patients. The Program fosters research across three thematic areas: (1) Prevention/risk reduction; (2) Screening/early detection; and (3) Quality of life/quality of care. Cross-cutting themes include research on communications, and translation/dissemination/adoption, with a developing health services research theme. The Program consists of 21 members from 10 departments accounting for $6.6 million in total funding, of which $4 million is from the NCI. This group of investigators has published 268 peer-reviewed manuscripts during the current funding period, of which 88 (33%) were joint publications with other programs, indicating a high degree of inter-programmatic collaboration, a substantial increase in such activity since the last review. In addition, 79 (29%) of the publications were intra-programmatic, reflecting collaborative work among our 21 program members. Program highlights include novel findings in all three thematic areas. Prevention researchers have published and disseminated findings from a trial to promote sun-safe behaviors among adolescents. They have published research showing a relation between exposure to smoking in movies and adolescent smoking, research that forms the basis for a public health campaign to reduce movie smoking depictions. Screening researchers lead one of 5 mammography registries in the U.S. and are disseminating successful interventions to promote cancer screening in primary care. Program members ask penetrating questions about the utility of current approaches to cancer screening, given issues such as over-diagnosis bias. Quality-of-life researchers have published novel findings on the adverse effects of cancer treatments on cognitive function, showing also that the epsilon 4 allele of APOE is associated with higher risk for this complication. Communications researchers are devising effective ways to discuss treatment and medication decisions with patients and working with the FDA to disseminate them. We are building our capacity to do research in communications and health services delivery through a recruitment and mentorship program. Program leaders host regular meetings among members and across programs to foster collaboration and ensure mentorship of young investigators, and members participate in a T32 Ph.D. training program in health services research. Going forward, the Program anticipates additional recruitment and continued expansion in areas of strength, including research into media influences on cancer risk behaviors, mammography research, and dissemination of practice systems of care to support cancer screening.

癌症控制计划的使命是促进合作研究，以降低癌症风险和死亡率并提高癌症患者的生活质量。该计划促进三个领域的研究专题领域： (1) 预防/减少风险； (2) 筛查/早期发现； (3) 生活质量/生活质量关心。跨领域主题包括传播研究、翻译/传播/采用、具有发展中的卫生服务研究主题。该计划由来自 10 个国家的 21 名成员组成各部门的总经费为 660 万美元，其中 400 万美元来自 NCI。这组研究人员在当前资助期间发表了 268 篇经过同行评审的手稿，其中 88 篇 (33%) 是与其他项目联合出版的，表明项目间的高度合作自上次审查以来此类活动大幅增加。此外，79 人（29%）出版物是计划内的，反映了我们 21 个计划成员之间的协作工作。计划亮点包括所有三个主题领域的新颖发现。预防研究人员发表了并传播一项促进青少年防晒行为的试验结果。他们有已发表的研究显示电影中吸烟与青少年吸烟之间的关系，这项研究为减少电影中吸烟镜头的公共卫生运动奠定了基础。筛选研究人员领导着美国 5 个乳房 X 光检查登记处之一，并正在传播成功的成果促进初级保健癌症筛查的干预措施。项目成员提出尖锐问题鉴于过度诊断偏差等问题，关于当前癌症筛查方法的实用性。生活质量研究人员发表了关于癌症治疗对人的不利影响的新发现认知功能，还表明 APOE 的 epsilon 4 等位基因与较高的风险相关并发症。传播研究人员正在设计有效的方法来讨论治疗和药物治疗与患者一起做出决定并与 FDA 合作传播这些决定。我们正在建设我们的能力通过招聘和指导计划进行通信和卫生服务提供方面的研究。项目负责人在成员之间和跨项目之间定期召开会议，以促进合作和确保对年轻研究人员的指导，成员参加 T32 博士项目。健康培训计划服务研究。展望未来，该计划预计将进一步招募人员并继续扩大优势领域，包括媒体对癌症风险行为影响的研究、乳房X光检查研究和传播护理实践系统以支持癌症筛查。