Informatics/Bioinformatics

信息学/生物信息学

基本信息

批准号：
7944556
负责人：
DAVID W MOUNT
金额：
$ 23.26万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-19 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7944556
关键词：
Applications Grants Arizona Arts Bioinformatics Biological Biological Models Biometry Cancer Center Cancer Center Support Grant Clinical Clinical Data Clinical Trials Collaborations Communities Computing Methodologies Consultations Data Data Analyses Data Quality Data Security Data Set Data Storage and Retrieval Databases Diagnostic Drug Delivery Systems Ensure Environment Gene Expression Genetic Population Study Genomics Goals Grant Group Meetings Haplotypes Health Insurance Portability and Accountability Act Health Services Research Individual Informatics Information Technology Knowledge Lead Malignant Neoplasms Methods Modeling Molecular Genetics Pathway Analysis Pattern Preclinical Drug Evaluation Proteomics Quality Control RNA Interference Research Research Personnel Resource Informatics Safety Services Students Tissue Microarray Tissues Training Writing analytical method base cancer genome data integration data management data modeling data sharing drug testing genome sequencing high throughput analysis meetings member new technology patient privacy programs repository skills tool web site

项目摘要

9.1.8 INFORMATICS & BIOINFORMATICS SHARED SERVICE The long term objective ofthe Bioinformatics Shared Service is to provide Arizona Cancer Center programs and membership with state-of-the-art methods for high throughput data analysis methods and data access including gene expression, proteomics, cancer genome analysis, RNAi and drug screens, and SNP based population genetic studies. The Service will achieve this objective through proven computational expertise and data management skills of the Informatics and Bioinformatics facility staff. In the previous period of core grant support, the Bioinformatics group has been actively involved in the extraction of biological information from large data sets that lead to testable hypotheses and data models, new information on the cancer genome, new drug targets, and useful diagnostic patterns. The Service has also served Cancer Center membership in each ofthe 5 Programs and has aiso interacted closely with 3 other shared services (Genomics, Proteomics, Biometry) by providing data storage and by sharing data analysis tools and methods. These activifies will be extended and enhanced as needed during the next grant period. A second long term objective of the Service is to assist in meeting the informatics needs of Cancer Center Programs, services, and individual grants. We will continue to provide web sites and databases for data and information sharing for individual grants and projects. Interactive support will also be provided towards the long term goal of establishing an overall plan for data integration and management. We will assist with the integration of proteomics, cancer genome, molecular, and genetic data with clinical data and other data as needed by continuing to participate in the CaBIG project and utilizing their informatics tools for data sharing, integration, and analysis. Finally, we will continue to collaborate with Cancer Center colleagues by meeting to discuss new research directions, attending lab and group meetings and discussion groups, training students, post-doctoraltrainees, and fellows, and assisting in writing new and continuing grant applications.

9.1.8 信息学与生物信息学共享服务生物信息学共享服务的长期目标是提供亚利桑那州癌症中心项目和拥有最先进的高通量数据分析方法和数据访问方法的成员资格，包括基因表达、蛋白质组学、癌症基因组分析、RNAi 和药物筛选以及基于 SNP 的群体遗传学研究。该服务将通过经过验证的计算专业知识和数据来实现这一目标信息学和生物信息学设施工作人员的管理技能。上期核心补助金的支持下，生物信息学组一直积极参与从大数据中提取生物信息可得出可检验的假设和数据模型的数据集、癌症基因组的新信息、新药物目标和有用的诊断模式。该服务还为 5 个国家的癌症中心会员提供服务计划并与其他 3 个共享服务（基因组学、蛋白质组学、生物测定学）密切互动提供数据存储并共享数据分析工具和方法。这些活动将被延长并在下一个资助期内根据需要进行加强。该服务的第二个长期目标是协助满足癌症中心项目、服务和个人资助的信息学需求。我们将继续为个人赠款和项目的数据和信息共享提供网站和数据库。交互的还将为制定数据集成总体计划的长期目标提供支持管理。我们将协助蛋白质组学、癌症基因组、分子和遗传数据的整合继续参与 CaBIG 项目并利用其所需的临床数据和其他数据用于数据共享、集成和分析的信息学工具。最后，我们将继续与癌症合作中心同事通过开会讨论新的研究方向、参加实验室和小组会议以及讨论小组，培训学生、博士后实习生和研究员，并协助撰写新的和持续的拨款申请。