Resource for Quantitative Functional MRI

定量功能 MRI 资源

基本信息

批准号：
7928341
负责人：
Peter CM Van Zijl
金额：
$ 49.81万
依托单位：
HUGO W. MOSER RES INST KENNEDY KRIEGER
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-30 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7928341
关键词：
Achievement Aging Anatomy Area Arts Attention Base of the Brain Beds Biomedical Engineering Biomedical Informatics Research Network Biomedical Research Brain Brain imaging Child Childhood Clinical Clinical Research Collaborations Commit Communities Complex Computer software Computers Dementia Development Discipline Disease Elderly Engineering Environment Fees Functional Magnetic Resonance Imaging Funding Grant Human Resources Image Imaging technology Individual Institutes Institution Investments Ischemia Knowledge Laboratories Letters Location Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Malignant Neoplasms Maps Maryland Medical Mental Retardation Mental disorders Metabolism Methodology Methods Metric Mission Modality Nature Neuraxis Neurologic Neurology Neurosciences Noise Pathology Patients Physics Physiologic pulse Physiological Population Process Progress Reports Protocols documentation Psyche structure Psychiatry Psychology Psychotic Disorders Publications Radiology Specialty Reporting Research Research Ethics Committees Research Infrastructure Research Personnel Resources Scanning Science Scientist Sedation procedure Services Short-Term Memory Side Signal Transduction Site Spectrum Analysis Speed Stroke Students Supercomputing System Technology Tissues Training Translating Translational Research Trauma United States National Institutes of Health Universities Vertebral column Visit Washington Work base clinical practice computerized computerized data processing data acquisition design disability hemodynamics image processing improved independent component analysis investigator training magnetic field medical schools multidisciplinary new technology novel programs reconstruction research and development research facility research study supercomputer white matter

项目摘要

DESCRIPTION (provided by applicant): The Resource for Quantitative Functional Magnetic Resonance Imaging is an interdepartmental and interdisciplinary laboratory combining facilities of the P.M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute (KKI) and the Center for Imaging Science (CIS) at Johns Hopkins University (JHU). This Resource Center is dedicated to using its unique expertise to design novel MRI and MRS data acquisition and processing technology in order to facilitate the biomedical research of a large community of clinicians and neuroscientists at several institutions in Maryland and throughout the USA, with a special focus on pediatric and neurodevelopmental applications. These NIH-funded researchers have a continued need for the development of new quantitative technology to better achieve the aims in their grants, which focus on topics such as mental retardation, trauma, impaired brain development, attention, working memory, psychosis, cancer, stroke, and the understanding of brain function. The Kirby Center has 1.5T and 3T state of the art scanners equipped with parallel imaging capabilities and high-end (4.5 and 8 G/cm whole body) gradients, and will be extended with a wide-bore 7T scanner, where important benefits such as higher signal to noise and better signal dispersion for MR spectroscopy are expected. CIS has an IBM supercomputer that is part of a national supercomputing infrastructure. Our Resource combines a strong technical environment with unique expertise of the collaborators especially valuable for studies in children, the elderly, and subjects with neurological and psychiatric disorders. This is reflected in the technical research and development (TRD) projects that focus on reducing the need for compliance in difficult populations (the very young, the elderly, and the mentally impaired) and on multi-modality assessment of tissue changes, arid apparent alterations in brain activation and/or pathology, when the brain

描述（由申请人提供）：定量功能磁共振成像的资源是p.m.肯尼迪·克里格研究所（KKI）的柯比功能性脑成像研究中心和约翰·霍普金斯大学（JHU）的成像科学中心（CIS）。该资源中心致力于利用其独特的专业知识来设计新颖的MRI和MRS数据采集和处理技术，以促进马里兰州和整个美国多个机构的大型临床医生和神经科学家社区的生物医学研究，并特别关注儿科和神经发育应用程序。这些由NIH资助的研究人员持续需要开发新的定量技术，以更好地实现其赠款的目标，这些技术重点介绍了诸如智力降低，创伤，脑发育受损，注意力，工作记忆，精神病，癌症，癌症，中风和对大脑功能的理解等主题。 Kirby Center具有1.5T和3T最先进的扫描仪，配备了平行成像功能以及高端（4.5 g/cm全身）梯度，并将通过宽孔7T扫描仪进行扩展，在此重要的好处，例如更高的信号对噪声和更好的信号分散，预计MR Spectroscoscopy有预计。 CIS具有IBM超级计算机，它是国家超级计算基础架构的一部分。我们的资源将强大的技术环境与合作者的独特专业知识相结合，对于儿童，老年人以及神经和精神病患者的研究特别有价值。这反映在技术研发（TRD）项目中，着重于减少符合困难人群（非常年轻，老年人和精神障碍）的依从性以及组织变化的多模态评估，当大脑激活和/或病理学的明显变化，而大脑的多模态性变化