Nutrition and Superfund Chemical Toxicity

营养和超级基金化学毒性

• 批准号: 7897031
• 负责人: BERNHARD HENNIG
• 金额: $ 15.31万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7897031
• 关键词: Nutrition; Superfund; Chemical; Toxicity

DESCRIPTION (provided by applicant) The University of Kentucky is unique among land grant universities in that all colleges, including Medicine and Agriculture, are located on the same campus. This constellation of programs has enabled the UK-SBRP to develop uniquely productive collaborations across diverse disciplines. Such an environment will allow to study the overall theme of the SBRP research, which focuses on the toxicology of Superfund chemicals and how health effects of exposure can be modulated by both intrinsic and extrinsic factors, namely genetics and nutrition, respectively. Given the abundance of Superfund chemicals and widespread distribution in the ecosystem, it is unlikely that remediation alone will be sufficient to address their health risks. Nutritional intervention thus becomes a sensible way to address health problems associated with environmental pollutants. In the competing renewal, the investigators recognize this dual need for sensing/remediation and biomedical intervention through nutrition by proposing five integrated projects. The investigators will concentrate on chlorinated organics (e.g., polychlorinated biphenyls) prevalent in most Superfund sites, including those found in Kentucky. Preliminary findings by this group suggest that nutrition and dietary habits can markedly influence mechanisms of toxicity of the above-mentioned Superfund chemicals. Thus, a major objective of our SBRP is to explore the paradigm that nutrition can modify Superfund chemical toxicity. All biomedical projects will focus on chronic diseases associated with vascular dysfunction, such as cardiovascular disease, cancer metastasis, and obesity-related abdominal aortic aneurysms, and will utilize a similar dietary fat regimen to study nutrient/toxicant interactions. There will be significant cross-talk with non-biomedical projects, which will explore novel techniques for both remediation (detoxification) and biosensors associated with detection of PCBs and other chlorinated organics. Results from interdisciplinary research will be utilized for information/education, technology transfer, training, policy and translational purposes as part of the objectives of the Research Translation, Community Outreach, and Training Cores. Nutrition may be the most sensible means to develop primary prevention strategies of diseases associated with many environmental toxic insults. Thus, research proposed by the investigators may lead to novel dietary recommendations at the national level for populations at risk, thus improving the health of people residing near Superfund sites. ADMINISTRATIVE CORE Description (provided by applicant) The Administrative Core (Core A) will oversee the entire Superfund Basic Research Program through a management mechanism that allows efficient and accountable oversight and maximum interdisciplinary and multidisciplinary interactions among all participants. The Administrative Core will be responsible for the coordination, planning, assessment, project accounting, and administrative support to the research personnel of the University of Kentucky SBRP. A major objective of the Administrative Core is to facilitate the execution of an interdisciplinary research theme through administrative support and fiscal accountability. The Administrative Core will work especially closely with the Research Translation Core (Core C) to optimize communication with NIEHS, EPA, and state and local constituents; communication is also facilitated by an active website that is managed by Core C with input from the Administrative Core. Research efforts will be coordinated through biweekly meetings of faculty, students and research staff, as well as seminars, where new findings and planned activities and ideas will be discussed. It will also be critical to discuss research findings for informative/educational activities, technology transfer, training, policy and translational purposes as part of the objectives of the Research Translation, Community Outreach, and Training Cores. The Administrative Core will implement feedback and cross-talk between all project and core activities to allow for maximum integration. For example, optimal detection and remediation of Superfund pollutants must be linked to risk assessment and biomedical aspects of degradation products. Accountability of the University of Kentucky SBRP activities, including the quality of science and administration, will be achieved through regular consultations with both the External and Internal Advisory Boards. Research quality assessment and statistical consultation will be managed through the Research Support Core. General fiscal responsibilities or project accounting will be coordinated through the Administrative Office in conjunction with the University of Kentucky Research Foundation. The Program Coordinator together with the Program Director will serve as a regular contact among all SBRP activities, including research projects and cores, and will coordinate all reports required by the sponsoring agencies.

描述（由申请人提供） 肯塔基大学在土地赠款大学中是独一无二的，包括医学和农业在内的所有大学都位于同一校园。这个计划的星座使英国SBRP能够在各种学科之间开展独特的生产效率。这样的环境将允许研究SBRP研究的总体主题，该研究的重点是超级基金化学物质的毒理学以及如何通过内在和外在因素（即遗传学和营养）调节暴露的健康影响。鉴于生态系统中大量的超级基金化学物质和广泛的分布，仅凭补救措施就不可能足以应对其健康风险。因此，营养干预成为解决与环境污染物相关的健康问题的明智方法。在竞争的续约中，调查人员通过提出五个综合项目来认识到通过营养通过营养进行感测/修复和生物医学干预的双重需求。研究人员将集中于大多数超级基金部位，包括在肯塔基州发现的氯化有机物（例如多氯联苯）。该组的初步发现表明，营养和饮食习惯可以显着影响上述超级基金化学物质的毒性机制。因此，我们SBRP的一个主要目的是探索营养可以改变超级基金化学毒性的范式。所有生物医学项目都将侧重于与血管功能障碍有关的慢性疾病，例如心血管疾病，癌症转移和与肥胖相关的腹部主动脉瘤，并将利用类似的饮食脂肪方案来研究养分/毒性相互作用。非生物医学项目将有明显的跨对词，该项目将探索与检测PCB和其他氯化有机物相关的补救（排毒）和生物传感器的新技术。跨学科研究的结果将用于信息/教育，技术转移，培训，政策和翻译目的，这是研究翻译，社区外展和培训核心目标的一部分。营养可能是制定与许多环境有毒侮辱相关的疾病的主要预防策略的最明智手段。因此，研究人员提出的研究可能会导致国家人口中有风险的人口的新饮食建议，从而改善了居住在超级基金地点附近的人们的健康。 行政核心 描述（由申请人提供） 行政核心（核心A）将通过管理机制来监督整个超级基础研究计划，该机制允许所有参与者之间有效，负责的监督以及最大的跨学科和多学科互动。行政核心将负责肯塔基大学SBRP大学研究人员的协调，计划，项目会计和行政支持。行政核心的一个主要目标是通过行政支持和财政责任来促进跨学科研究主题的执行。行政核心将与研究翻译核心（Core C）特别紧密地合作，以优化与NIEHS，EPA，州和地方选民的沟通；通过核心C管理的活跃网站还通过管理核心的输入来促进通信。研究工作将通过教师，学生和研究人员以及研讨会的每两周举行会议进行协调，并将讨论新的发现，计划的活动和想法。讨论有关信息/教育活动，技术转移，培训，政策和翻译目的的研究结果，作为研究翻译，社区外展和培训核心目标的一部分。行政核心将在所有项目和核心活动之间实施反馈和串扰，以最大程度地集成。例如，对超级基金污染物的最佳检测和修复必须与降解产物的风险评估和生物医学方面有关。肯塔基大学SBRP活动的问责制，包括科学和管理的质量，将通过与外部和内部咨询委员会的定期咨询来实现。研究质量评估和统计咨询将通过研究支持核心进行管理。一般的财政责任或项目会计将与肯塔基大学研究基金会结合通过行政办公室进行协调。计划协调员与计划主任将在包括研究项目和核心在内的所有SBRP活动之间进行定期联系，并将协调赞助机构要求的所有报告。