Center for Environmental and Health Effects of PFAS

PFAS 环境与健康影响中心

基本信息

批准号：
10115848
负责人：
Antonio J. Planchart
金额：
$ 12.12万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-28 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10115848
关键词：
Address Affect Age Alligators Biology Chemical Structure Chemicals Clinical Cohort Studies Complement Consumption Controlled Study Diet Ecology Ecosystem Environment Environmental Engineering technology Environmental Health Environmental Risk Factor Evaluation Exposure to Fishes Food Food Webs Foundations Fresh Water Fright Future Generations Goals Hazard Assessment Health Human Individual Investigation Kinetics Laboratories Laboratory Study Life Link Measures Modeling Movement Nature Organism Outcome Phase Plants Production Reporting Research Research Project Grants Resources Risk Management Rivers Safety Sampling Source Structure Superfund Testing Tissues Toxic effect Uncertainty Water Work Zebrafish aquatic organism aqueous base bioaccumulation chemical release dietary drinking water exposed human population exposure pathway exposure route field study immune function laboratory experiment nutrition predictive modeling uptake

项目摘要

ABSTRACT (Environmental Science and Engineering) Research Project 3 Per- and polyfluoroalkyl substances (PFAS) are chemicals that are of emerging concern because they are widely released into the environment where they tend to be persistent and bioaccumulative. Some PFAS are associated with adverse health outcomes in people, and production of a limited number of them (e.g., PFOA and PFOS) has been phased out due to these concerns. However, there are approximately 5,000 PFAS, and there is considerable uncertainty regarding the human health and environmental safety of these compounds because most PFAS have never been tested. Because these compounds are routinely released into waterways that serve as sources of drinking water and nutrition via consumption of fish and aquatic wildlife, there is an immediate need to better understand their environmental fate and effects. As concerns about PFAS in the environment are beginning to grow, there are increasing reports of the presence of these compounds in water and in aquatic organisms, but our understanding of their bioaccumulation potential and toxicity to aquatic life is limited. This project specifically addresses concerns about the bioaccumulation and toxicity of PFAS in aquatic food webs. One major goal of this project is to compare the accumulation of PFAS (12 different compounds) in a food web context by comparing aqueous uptake in primary producers (periphyton), primary consumers (mayflies), and secondary consumers (zebrafish) in the laboratory. A second major goal is to understand the potential for different compounds to move trophically in food webs by measuring the movement of different compounds from periphyton to mayflies to fish. Only by doing controlled studies in the laboratory can we systematically understand the bioaccumulation dynamics of these different compounds based on their different chemical structures. The next major goal of this work is to compare the toxicity of different PFAS to zebrafish. While zebrafish is a recognized model for human health studies, this project utilizes the deep understanding of this species' biology to explore the consequences of PFAS exposure to fish. The project will compare the toxicity of 12 different compounds in zebrafish using traditional toxicity approaches (exposures from water) but will be unique in that it will also assess the potential for dietary PFAS exposures to contribute to toxicity because in nature, exposures are likely to both PFAS in water and in the diet. Finally, these laboratory studies will be complemented by field investigations of PFAS in local waterways and in the tissues of aquatic fish and wildlife. This work is prompted by local contamination of a major watershed by a PFAS manufacturing plant and associated concerns about real-world exposures. Specifically, the project will measure PFAS in fish and wildlife (alligators) that are potential dietary exposure routes of these contaminants to people. Together, the project will provide much needed information about the bioaccumulation, toxicity, and exposure profiles of PFAS in the aquatic environment.

抽象的（环境科学与工程）研究项目3 每种和多氟烷基物质（PFA）是引起人们关注的化学物质，因为它们是广泛的释放到它们倾向于持久和生物蓄积的环境中。一些PFA是相关的在人中的健康状况不良，并且有限的人数有限（例如，PFOA和PFO）由于这些问题，已被淘汰。但是，大约有5,000个PFA，并且有关于这些化合物的人类健康和环境安全的严重不确定性，因为大多数PFA从未经过测试。因为这些化合物通常被释放到服务的水道中作为饮用水和营养的来源，通过食用鱼类和水生野生动植物，立即有需要更好地了解他们的环境命运和影响。由于对环境中PFA的担忧是开始增长，越来越多的报道说这些化合物在水中和水生中存在有机体，但是我们对它们的生物蓄积潜力和对水生生物的毒性的理解是有限的。这项目专门解决了对水生食物网中PFA的生物积累和毒性的担忧。该项目的主要目标是比较食品网中PFA（12种不同化合物）的积累通过比较主要生产商（periphyton），主要消费者（Mayflies）和实验室中的二级消费者（斑马鱼）。第二个主要目标是了解潜力不同化合物通过测量不同化合物的运动从围叶顿五月蝇。只有在实验室中进行对照研究，我们才能系统地理解这些不同化合物的生物积累动力学基于它们的不同化学结构。这这项工作的下一个主要目标是将不同的PFA与斑马鱼的毒性进行比较。而斑马鱼是公认的人类健康研究模型，该项目利用了对该物种生物学的深刻理解探索PFA暴露于鱼的后果。该项目将比较12种不同的毒性斑马鱼中的化合物使用传统毒性方法（水暴露），但它是独一无二的还将评估饮食中PFA暴露有助于毒性的潜力，因为在自然界中在水中和饮食中都可能是PFA。最后，这些实验室研究将由现场补充对当地水道和水生鱼类和野生动植物组织中的PFA进行调查。这项工作是提示的通过PFAS制造厂对主要流域的局部污染，并与之相关的担忧现实世界的暴露。具体而言，该项目将测量潜在的鱼类和野生动植物（鳄鱼）中的PFA 这些污染物对人的饮食暴露路线。该项目将共同提供急需的有关PFA在水生环境中的生物累积，毒性和暴露概况的信息。