UCSC Center for Genomic Science and Minority Outreach Program

UCSC 基因组科学中心和少数族裔外展计划

• 批准号: 7921323
• 负责人: DAVID H HAUSSLER
• 金额: $ 69万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921323
• 关键词: Address; Aging; Applications Grants; Architecture; Archives; Area; Biomedical Research; Communities; Confidentiality; Data; Data Quality; Data Set; Data Storage and Retrieval; Databases; Disease; Documentation; Feasibility Studies; Floods; Galaxy; Genbank; Genome; Genomics; Goals; Human; Imagery; Individual; Internet; Invertebrates; Large-Scale Sequencing; Link; Malignant Neoplasms; Maps; Medical; Methods; Minority Outreach Program; Mission; Modeling; Online Systems; Participant; Performance; Privacy; Process; Publications; Quality Control; Research; Research Personnel; Resources; Running; Science; Scientist; Secure; Sequence Alignment; Services; Site; Solutions; Somatic Cell; System; Time; Tissues; Training; Travel; Variant; Weight; Work; base; biomedical resource; biomedical scientist; comparative; firewall; flexibility; improved; indexing; next generation; prototype; tool

The UCSC Genome Browser (genome.ucsc.edu) is a vital resource for the biomedical community, providing timely, convenient access to sequence and annotations for the human and all other vertebrate reference species genomes, along with selected model invertebrates. However, the enormous capacity of next-generation sequencing platforms is rapidly outstripping all of the resources we can provide. Additionally, biomedical datasets are increasingly deemed to potentially contain identifying data, which raises substantial privacy protection issues. In this proposal, we outline a project to expand the Genome Browser architecture to address these growing data volume and privacy requirements. Our preliminary studies indicate that cloud computing and a web services model (such as is supported by Amazon) may provide a good solution to our data storage requirements and offer a high-performance solution for mapping, visualizing, and analyzing next-generation sequencing data, as well as providing a personalized browsing solution for biomedical research scientists who require an individual instance of the Genome Browser for confidentiality or configurability reasons, but wish to avoid the overhead of installing a local mirror of our browser. Through this project we plan to complete a feasibility study of the cloud computing solution and investigate (and potentially prototype) a web services architecture for the Genome Browser. We will also streamline the Genome Browser mirror site installation package for those labs that still require a local copy of the browser. Through this work, we will enhance biomedical research through an enhanced Genome Browser toolset that provides high-performance access to large datasets and controlled access for the visualization and analysis of confidential datasets.

UCSC基因组浏览器（Genome.ucsc.edu）是生物医学的重要资源 社区，为及时，方便访问顺序和注释 人类和所有其他脊椎动物参考物种基因组，以及选定的 模型无脊椎动物。但是，下一代的巨大能力 测序平台正在迅速超越我们可以提供的所有资源。 此外，生物医学数据集越来越被视为可能包含 识别数据，这引发了大量隐私保护问题。在此提案中， 我们概述了一个扩展基因组浏览器体系结构以解决这些项目的项目 增长的数据量和隐私要求。 我们的初步研究表明云计算和Web服务模型 （例如亚马逊支持）可以为我们的数据存储提供一个很好的解决方案 要求并提供高性能解决方案，用于映射，可视化和 分析下一代测序数据，并提供个性化的 需要个人的生物医学研究科学家浏览解决方案 基因组浏览器的实例出于机密性或可配置性原因，但 希望避免安装我们浏览器的本地镜像的开销。通过这个 我们计划完成对云计算解决方案的可行性研究和 研究基因组的Web服务体系结构（并可能原型） 浏览器。我们还将简化基因组浏览器镜像网站安装 对于仍然需要浏览器本地副本的那些实验室的软件包。 通过这项工作，我们将通过增强来增强生物医学研究 基因组浏览器工具集，可提供高性能访问大型数据集 并控制访问机密数据集的可视化和分析。