Development of a Cardiovascular Surveillance System in the CVRN

CVRN 心血管监测系统的开发

• 批准号: 7941918
• 负责人: Stephen Sidney
• 金额: $ 375.34万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7941918
• 关键词: Accounting; Acute myocardial infarction; Address; Area; Cardiovascular Diseases; Cardiovascular system; Caring; Cause of Death; Characteristics; Clinical; Communities; Comorbidity; Coronary heart disease; Data; Data Aggregation; Databases; Development; Diagnostic; Disease; Ethnic Origin; Event; Facilities and Administrative Costs; Funding; Goals; Health Maintenance Organizations; Health Planning; Healthcare; Heart Diseases; Heart failure; Hospitalization; Incidence; Intervention; Laboratories; Life; Measures; Medical; Methods; Modality; Monitor; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Outcome; Patients; Pattern; Pharmaceutical Preparations; Physicians; Population; Prevalence; Preventive Intervention; Productivity; Provider; Public Health; Qualifying; Race; Reporting; Research; Research Personnel; Risk Factors; Scientist; Secondary Prevention; Severities; Site; Stroke; System; Testing; Therapeutic Intervention; Time; Treatment outcome; Work; burden of illness; comparative effectiveness; cost; disability; economic cost; effective intervention; health disparity; intervention program; longitudinal course; member; mortality; novel; prevent; programs; public health relevance; trend

DESCRIPTION (provided by applicant): This project will establish a surveillance system for cardiovascular disease in approximately 11 million health maintenance organization (HMO) members. The surveillance system will be initially established for coronary heart disease (CHD), heart failure (HF), and stroke. The broad goals of this project are to: 1. Establish a surveillance system for coronary heart disease (CHD), heart failure (HF) and stroke in the 15 centers of the National Heart Lung and Blood Institute (NHLBI) funded Cardiovascular Disease Research Network including therapeutic interventions, post-event outcomes and important risk factors and confounders. 2. Work collaboratively to establish and implement an aggregate database incorporating coronary heart disease CHD, HF, and stroke data from all 15 CVRN sites that can be used by CVRN investigators and other qualified research scientists to conduct studies related to comparative effectiveness and health disparities. 3. Identify standard criteria for coronary heart disease, heart failure and stroke clinical outcomes, as well as all components noted in goal #1 to enable data aggregation 4. Determine the most recent 10-year trends in the rates of acute myocardial infarction and stroke hospitalization and their relationship to trends in risk factors, co-morbidities, therapeutic interventions, medications, and diagnostic modalities. 5. Demonstrate that the data can be used to address research questions regarding comparative effectiveness and novel methods of monitoring health disparities, areas that have been identified as RC2 topics by NHLBI. This project will result in a surveillance system in a consortium of 15 geographically diverse health plans that provide health care to about 11 million people, nearly 4% of the U.S. population. This surveillance system will be significantly larger than other existing cardiovascular surveillance efforts in the U.S. and includes a population that is diverse in race/ethnicity and sociodemographic characteristics. The surveillance system will include for CHD, HF, and stroke electronically available data on risk factors, co-morbidities, prescription medications, therapeutic interventions, and laboratory testing, and physician and patient characteristics. These data can be utilized to provide timely surveillance reports for CHD, CF, and stroke; a comprehensive description of a patient's longitudinal course both prior to and subsequent to development of CHD, CF, and stroke; and enable research questions to be addressed that assess the relationship of these variables to the course of disease as well as to address research questions relating to comparative effectiveness and to disparities in medical treatment and outcomes. PUBLIC HEALTH RELEVANCE: This project will establish a large database of information about heart disease and stroke in about 11 million members of 15 HMO providers of comprehensive medical care. This information will be used to examine patterns over time in the rates of heart disease and stroke, the first and third leading causes of death in the U.S. These data will enable the medical and public health community to assess progress over time in reducing the rate of these deadly and expensive diseases, to help identify interventions that are effective in preventing heart disease and stroke as well as interventions that favorably impact the lives of those who live with these conditions.

描述（由申请人提供）：该项目将为约 1100 万健康维护组织 (HMO) 成员建立心血管疾病监测系统。初步建立冠心病（CHD）、心力衰竭（HF）和脑卒中的监测系统。该项目的总体目标是： 1. 在国家心肺和血液研究所 (NHLBI) 资助的心血管疾病研究网络的 15 个中心建立冠心病 (CHD)、心力衰竭 (HF) 和中风的监测系统包括治疗干预、事件后结果以及重要的风险因素和混杂因素。 2. 协作建立和实施一个综合数据库，其中包含来自所有 15 个 CVRN 站点的冠心病 CHD、HF 和中风数据，CVRN 调查人员和其他合格的研究科学家可以使用该数据库来开展与比较有效性和健康差异相关的研究。 3. 确定冠心病、心力衰竭和中风临床结果的标准标准，以及目标 1 中提到的所有组成部分以实现数据汇总 4. 确定急性心肌梗死和中风发病率的最近 10 年趋势住院治疗及其与危险因素、合并症、治疗干预、药物和诊断方式趋势的关系。 5. 证明数据可用于解决有关比较有效性和监测健康差异的新方法的研究问题，这些领域已被 NHLBI 确定为 RC2 主题。该项目将在由 15 个不同地区的健康计划组成的联盟中建立一个监测系统，为约 1100 万人（占美国人口的近 4%）提供医疗保健。该监测系统将比美国现有的其他心血管监测工作规模大得多，并包括具有不同种族/民族和社会人口特征的人群。该监测系统将包括冠心病、心力衰竭和中风的危险因素、合并症、处方药、治疗干预、实验室检测以及医生和患者特征的电子可用数据。这些数据可用于及时提供 CHD、CF 和中风的监测报告；对患者在发生 CHD、CF 和中风之前和之后的纵向病程的全面描述；并能够解决评估这些变量与疾病进程的关系的研究问题，以及解决与相对有效性以及医疗治疗和结果差异相关的研究问题。 公共健康相关性：该项目将建立一个大型数据库，其中包含 15 个 HMO 综合医疗服务提供者的约 1100 万会员的心脏病和中风信息。这些信息将用于检查心脏病和中风的发病率随时间变化的模式，心脏病和中风是美国第一和第三大死亡原因。这些数据将使医疗和公共卫生界能够评估随着时间的推移在降低心脏病和中风发病率方面取得的进展。这些致命且昂贵的疾病，以帮助确定有效预防心脏病和中风的干预措施，以及对患有这些疾病的人的生活产生有利影响的干预措施。