Complicated Grief in Older Adults: Physiological Substrates of Emotion Regulation

老年人复杂的悲伤：情绪调节的生理基础

• 批准号: 7841729
• 负责人: MARY-FRANCES O'CONNOR
• 金额: $ 11.64万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7841729
• 关键词: Age; Aging; Anterior; Arousal; Attention; Attentional deficit; Bereavement; Brain region; CNS processing; Chronic; Cognitive; Consensus; Cues; Depression and Suicide; Development; Elderly; Emotional; Functional Magnetic Resonance Imaging; Goals; Grief reaction; Health; Image; Immunologic Markers; Immunology; Impaired cognition; Inflammatory; Interleukin-6; Interview; Investigation; K-Series Research Career Programs; Life; Measures; Mediating; Mentors; Neurophysiology - biologic function; Neuropsychological Tests; Patient Self-Report; Performance; Persons; Physiological; Population; Process; Psychoneuroimmunology; Psychosocial Stress; Public Health; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Structure; Testing; Thinking; Training; Widow; Widowhood; Work; anakinra; base; cingulate cortex; cytokine; emotion regulation; experience; immune activation; indexing; inflammatory marker; neuroimaging; neuroregulation; psychologic; relating to nervous system

DESCRIPTION (provided by applicant): Complicated Grief in Older Adults: Physiological Substrates of Emotion Regulation This application for a Career Development Award in Aging describes an integrated training plan and research project to allow the candidate to become an expert in the physiological underpinnings of emotion regulation in older adults. Conjugal bereavement is highly prevalent in older adults, with more than 900,000 people widowed each year in the U.S. Although most adjust gradually to widow(er)hood, others experience a complicated course. Complicated grief, which persists despite anti-depressant treatment, has been found to be an independent predictor of cognitive decline, poor health, depression and suicidality in older adults, making it a major public health concern. Cognitive factors, such as the inability to shift attention away from intrusive thoughts of the deceased are hypothesized to impair adjusting to a life as a widow(er). Furthermore, physiological mechanisms, such as low-grade inflammatory processes, may contribute to emotional dysregulation found in this population. The proposed research will assess neural activation, immune markers, and neuropsychological tests of attention and emotion regulation in older adults. We will recruit 135 older adults (45 with complicated grief, 45 with uncomplicated grief and 45 non-bereaved, determined by a structured interview with new consensus criteria). The specific aims are: Aim 1) To examine attentional deficits in older adults with complicated grief as measured by the e-Stroop as compared to controls (uncomplicated grief and non-bereaved); Aim 2) To examine the neural substrates of attentional deficits in a subsample of 36 older adults with fMRI in these three groups; Aim 3) To evaluate circulating markers of inflammation (e.g., sTNF-RII, IL-6, slL-6R and IL-1Ra) in older adults with complicated grief as compared to controls (uncomplicated grief and non-bereaved). The long-term goal of the project is to explore whether neural activity mediates the relationship between circulating markers of inflammation and attentional deficits. The Cousins Center for Psychoneuroimmunology at UCLA has both excellent resources (e.g. 3T imaging scanner) and excellent mentors (including Dr. Michael Irwin, MD) necessary for advanced training in bereavement, immunology, and neuroimaging research that will facilitate development of the candidate, Dr. Mary-Frances O'Connor, into an independent investigator and allow her to develop an R01 proposal to evaluate treatment for complicated grief, based on both physiological and psychological mechanisms.

描述（由申请人提供）：老年人的复杂悲伤：情绪调节的生理基质这一衰老职业发展奖的申请描述了一项综合的培训计划和研究项目，使候选人能够成为老年人情绪调节生理基础的专家。夫妻丧亲在老年人中非常普遍，尽管大多数人逐渐适应寡妇（ER）hood，但每年有90万人丧偶，其他人则经历了复杂的过程。尽管抗抑郁药治疗仍然存在，但复杂的悲伤仍被认为是老年人认知能力下降，健康状况不佳，抑郁和自杀性的独立预测指标，这使其成为主要的公共健康问题。假设认知因素，例如无法将注意力从死者的侵入性思想转移到寡妇（ER）（ER）的生活中。此外，生理机制，例如低级炎症过程，可能导致该人群中发现的情绪失调。拟议的研究将评估老年人注意力和情绪调节的神经激活，免疫标记和神经心理学测试。我们将招募135名老年人（45名复杂的悲伤，45个单纯的悲伤和45个未植物，由结构化的访谈确定，并获得了新的共识标准）。具体目的是：目标1）检查与对照组相比，通过电子突破来衡量的老年人的注意力缺陷（不复杂的悲伤和未筛选）；目标2）在这三组中，在36名患有fMRI的老年人的子样本中，检查注意力缺陷的神经底物；目标3）评估与对照组相比（单纯的悲伤和不复杂的悲伤和不复温）的老年人中炎症（例如STNF-RII，IL-6，SLL-6R和IL-1RA）的循环标记。该项目的长期目标是探索神经活动是否介导炎症标记和注意力缺陷之间的关系。加州大学洛杉矶分校的Cousins心理免疫免疫学中心既拥有出色的资源（例如3T成像扫描仪）和出色的指导者（包括迈克尔·艾尔温（Michael Irwin），医学博士，医学博士）进行丧亲，免疫学和神经影像学的高级培训所必需的研究，这些研究将促进候选人的发展，允许对候选人的开发，允许玛丽·弗兰斯（Mary-Francess）的发展，使其对独立研究所的开发，使其成为独立的研究室，并促进and and Indection Anor and and and and and Inderipate Anor and an RR 0基于生理和心理机制。