Yoga and Cardiovascular Disease Risk in Older Women

老年女性的瑜伽和心血管疾病风险

• 批准号: 7759632
• 负责人: KAREN-KIM E INNES
• 金额: $ 12.67万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7759632
• 关键词: Applications Grants; Area; Award; Behavior Therapy; Behavioral Medicine; Biology; Cardiovascular Diseases; Cause of Death; Chronic; Chronic Disease; Clinical; Comorbidity; Coupled; Discipline; Disease; Educational workshop; Epidemiologist; Fellowship; Goals; Health Care Costs; Insulin Resistance; Intervention; Intervention Studies; K-Series Research Career Programs; Lead; Menopause; Metabolic; Methods; Mind-Body Intervention; Non-Insulin-Dependent Diabetes Mellitus; Overweight; Physiology; Pilot Projects; Population; Postmenopause; Prevention; Productivity; Prophylactic treatment; Randomized; Research; Research Personnel; Research Training; Risk Factors; Risk Reduction; Solid; Stress; Syndrome; Therapeutic Intervention; Training; Training Programs; Woman; Women' s Health; Yoga; base; body-mind; cardiovascular disorder risk; cost; design; diabetic; experience; indexing; insulin sensitivity; meetings; non-diabetic; older women; programs; psychologic; sedentary; skills; skills training

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) remains the leading cause of death in women. CVD risk rises sharply with menopause and is further elevated among women with type 2 diabetes (DM 2). These increases are likely due to the coincident rise in insulin resistance and other, related atherogenic changes comprising the insulin resistance syndrome (IRS). There is growing evidence that the practice of yoga may offer a safe and cost-effective strategy for reducing IRS-related risk factors for CVD in both diabetic and non-diabetic populations. However, rigorous studies are few. The proposed K-01 award will provide the necessary training, skills, and experience for Dr. Kim Innes, an epidemiologist with a strong background in women's health and chronic disease and recent fellowship training in CAM, to conduct clinical intervention research regarding the effects of yoga on CVD risk reduction in women. Her long-term goal is to establish a successful research program investigating yoga for the prevention and management of CVD and related chronic, insulin resistance conditions. Immediate goals toward this end are, through a rigorous program of didactic training and research, to: 1) gain additional expertise in advanced quantitative methods, chronic disease physiology, and stress biology; 2) develop a solid practical and theoretical background in the field of mind-body and behavioral medicine, with a focus on yoga therapy; and 3) strengthen her skills in clinical intervention research and gain needed experience in behavioral intervention studies involving mind-body therapies. The candidate has assembled an exceptional sponsoring committee of investigators with extensive expertise in each of these disciplines, who will guide her activities and progress throughout the award period. The training program will include regular meetings with the lead sponsor and co-sponsors, coupled with participation in selected courses, tutorials, workshops, seminars, professional meetings and research practica relevant to Dr. lnnes's area of research. Dr. Innes will execute two pilot studies that will comprise the focus of the K award and the basis for at least two subsequent RO1 grant applications to be submitted within the award period. Using a randomized controlled design, these pilot studies will investigate the effects of a gentle 8-week lyengar yoga program on insulin sensitivity and related metabolic and psychological indices of CVD risk in two populations at elevated risk for CVD: sedentary, overweight postmenopausal women who are currently healthy and postmenopausal women with DM 2. The proposed studies will yield important information on the potential utility of a safe, inexpensive intervention in reducing CVD risk in both diabetic and healthy women postmenopause. If findings are positive and confirmed in other, larger studies, the use of yoga as a therapeutic intervention and prevention measure for CVD and related comorbidities could potentially save billions of dollars in health care costs and lost productivity due to these disorders.

描述（由申请人提供）：心血管疾病（CVD）仍然是妇女死亡的主要原因。 CVD风险随年后急剧上升，并且在2型糖尿病（DM 2）的女性中进一步升高。这些增加可能是由于包括胰岛素抵抗综合征（IRS）的其他相关的胰岛素抵抗和其他相关的动脉粥样变化所致。越来越多的证据表明，瑜伽的实践可能会提供一种安全且具有成本效益的策略，以减少与糖尿病和非糖尿病种群中CVD相关的IRS相关风险因素。但是，严格的研究很少。拟议的K-01奖将为具有强大的女性健康和慢性病和CAM近期研究金培训背景的流行病学家Kim Innes博士提供必要的培训，技能和经验，以进行有关瑜伽对CVD风险降低妇女的影响的临床干预研究。她的长期目标是建立成功的研究计划 研究瑜伽，以预防和管理CVD和相关的慢性胰岛素抵抗条件。通过严格的教学培训计划和 研究，TO：1）获得高级定量方法，慢性疾病生理学和压力生物学方面的额外专业知识； 2）在思维体内建立坚实的实用和理论背景 行为医学，重点是瑜伽疗法； 3）增强她在临床干预方面的技能 在涉及思维体疗法的行为干预研究方面的研究和增益经验。该候选人在每个学科中都有广泛的专业知识组成了一个杰出的调查员委员会，他们将在整个奖励期间指导她的活动和进步。该培训计划将包括与首席赞助商和共同发起人的定期会议，再加上与Lnnes博士研究领域有关的选定课程，教程，讲习班，研讨会，专业会议和研究实践。 Innes博士将执行两项试点研究，这些研究将构成K奖的重点以及至少两次随后的RO1赠款申请的基础。 Using a randomized controlled design, these pilot studies will investigate the effects of a gentle 8-week lyengar yoga program on insulin sensitivity and related metabolic and psychological indices of CVD risk in two populations at elevated risk for CVD: sedentary, overweight postmenopausal women who are currently healthy and postmenopausal women with DM 2. The proposed studies will yield important information on the potential utility of a safe, inexpensive降低糖尿病和健康女性CVD风险的干预措施。如果发现在其他大型研究中是积极的并确认的，则将瑜伽用作CVD及相关合并症的治疗干预和预防措施的使用可能会节省数十亿美元的医疗保健成本，并且由于这些疾病而导致的生产力降低。