EFFECTS OF YOGA ON INSULIN SENSITIVITY AND INDICES OF CARDIOVASCULAR RISK

瑜伽对胰岛素敏感性和心血管风险指数的影响

• 批准号: 7951461
• 负责人: KAREN-KIM E INNES
• 金额: $ 0.78万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951461
• 关键词: Blood Pressure; Blood specimen; Body Size; Cardiovascular Diseases; Cause of Death; Chronic Disease; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Data; Fasting; Funding; Grant; Heart Rate; Institution; Insulin Resistance; Lipids; Measures; Menopause; Physiological; Pilot Projects; Population; Postmenopause; Randomized; Research; Research Personnel; Resources; Risk; Risk Factors; Source; United States National Institutes of Health; Woman; Yoga; aged; cardiovascular disorder risk; cardiovascular risk factor; cost; glucose tolerance; heart rate variability; indexing; insulin sensitivity; prevent; programs; psychologic; sedentary; treatment as usual; treatment duration; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Risk for cardiovascular disease (CVD), the leading cause of death in women, rises sharply with menopause. There is growing evidence that the practice of yoga may offer a safe and cost-effective strategy for reducing risk factors for CVD. However, rigorous studies in Western populations are few and the effects of yoga on CVD risk profiles in healthy postmenopausal women have not been studied. This study will investigate the effects of a gentle 8-week yoga program on insulin resistance and related indices of cardiovascular risk in healthy postmenopausal women aged 50-70. Sixty eligible, sedentary volunteers will be randomized into yoga or control (usual care) groups. Before and after the 8-week treatment period, fasting blood samples will be collected, and specific markers of CVD risk will be measured. These will include measures of insulin resistance and glucose tolerance, as well as lipid profiles; heart rate, blood pressure, heart rate variability; body size and composition, and other related physiological and psychological markers of CVD risk. This exploratory pilot study may yield important information on the potential utility of yoga in preventing CVD in postmenopausal women, a population at increased risk for this and other related serious chronic disorders. Findings of this study will also provide preliminary data to support a larger clinical trial investigating the influence of yoga practice on indices of CVD risk in women post-menopause.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 心血管疾病的风险（CVD）是女性死亡的主要原因，随着更年期而急剧上升。 越来越多的证据表明，瑜伽的实践可能会为减少CVD的危险因素提供安全且具有成本效益的策略。但是，西方人群的严格研究很少，瑜伽对健康后妇女的CVD风险特征的影响尚未被研究。 这项研究将调查一个柔和的8周瑜伽计划对健康后50-70岁健康的绝经后妇女中胰岛素抵抗和心血管风险相关指数的影响。 六十名合格的久坐的志愿者将被随机分为瑜伽或对照组（常规护理）。在8周的治疗期之前和之后，将收集空腹血液样本，并测量CVD风险的特定标记。 这些将包括胰岛素抵抗和葡萄糖耐受性以及脂质谱的度量；心率，血压，心率变异性；体型和组成，以及CVD风险的其他相关生理和心理标记。 这项探索性试验研究可能会产生有关瑜伽在预防绝经后妇女中CVD的潜在效用的重要信息，这是该人群的这种和其他相关严重的严重慢性疾病的风险增加。 这项研究的结果还将提供初步数据，以支持一项更大的临床试验，该试验研究瑜伽实践对CVD风险指数对妇女的影响。