Growth and Cardiometabolic Risk Among In Utero Drug Exposed Children

子宫内药物暴露儿童的生长和心脏代谢风险

基本信息

批准号：
7903469
负责人：
Sarah Elizabeth Messiah
金额：
$ 16.42万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7903469
关键词：
18 year old Adolescence Adolescent Adult Affect African American Age Alcohol or Other Drugs use Alcohols Anxiety Arts Biological Markers Birth Blood Pressure Body Composition Body mass index Cardiovascular system Caregivers Child Childhood Chronic Disease Cocaine Cohort Studies Confidentiality Data Data Collection Demographic Factors Development Development Plans Disease Embryology Enrollment Environmental Risk Factor Ethnic Origin Evaluation Family Fetal Cocaine Exposure Florida Foundations Funding Gestational Age Goals Grant Growth Growth and Development function Health Height Infant Ingestion Insulin Interview Investigation K-Series Research Career Programs Knowledge Link Lipids Longitudinal Studies Marijuana Measures Meconium Mental Depression Mentored Research Scientist Development Award Mentors Metabolic syndrome Mothers Multivariate Analysis National Institute of Drug Abuse Nicotine Obesity Outcome Overweight Pharmaceutical Preparations Population Study Pregnancy Principal Investigator Protocols documentation Race Recruitment Activity Research Research Personnel Resources Risk Risk Factors Sampling Schedule Site Specialized Center Stress Substance abuse problem Syndrome TNFRSF5 gene Underweight Universities Urine Weight analytical method career development cocaine exposure cocaine use cohort design disorder risk early adolescence experience fasting glucose in utero low socioeconomic status medical schools neuropsychological offspring postnatal prenatal prenatal exposure public health relevance skills social waist circumference

项目摘要

DESCRIPTION (provided by applicant): This K01 award will allow the candidate, Dr. Sarah Messiah, to gain the skills, knowledge and experience required to become an independent investigator. Using data from the Miami Prenatal Cocaine Study (MFCS, Dr. Emmalee Bandstra, Principal Investigator), Dr. Messiah will examine the relationship between in utero cocaine exposure, anthropometric growth and development of cardiometabolic disease risk factors in African American children at ages 16-18. The MPCS has collected 11 prior waves of multi-domain data on over 400 infants and their mothers/alternate caregivers through early adolescence and is now embarking on 2 additional waves of data collection at ages 16 -18 years. The proposed mentored research has three specific aims: (1) To longitudinally compare anthropometric measures (height, weight, body mass index, waist circumference, and body composition) among urban, African American children and adolescents who were or were not prenatally exposed to cocaine using a previously established and well-characterized NIDA cohort; (2) To compare cardiometabolic risk factors (fasting glucose, insulin, lipids, CRP, blood pressure) cross-sectionally among urban, African American adolescents who were or were not exposed prenatally to cocaine using a previously established and well-characterized NIDA cohort; and (3) To determine the specific effects of both prenatal and postnatal exposures of cocaine in a repeated measures multivariate analysis, controlling for effect modifiers (nicotine, alcohol and marijuana exposure, stress, anxiety and depression in children and mothers) on: (a) Overweight and obesity, (b) Underweight, and (c) > 3 cardiometabolic risk factors (often referred to as "metabolic syndrome"). To achieve this research and her career development goals, Dr. Messiah will follow a career development plan at the University of Miami Miller School of Medicine, designed to provide knowledge, skills, and experience in 4 core competencies (hfe course of disease, with particular emphasis on in utero cocaine exposure, longitudinal/latent growth analytical methods, embryology, and cardiometabolic disease risk factor development in childhood and subsequent risk for adult onset chronic disease). The broad, long-term goal of the proposed research is to elucidate causal and non-causal links with a specific focus upon how in utero cocaine exposure might alter the occurrence and trajectories of anthropometric grovrth, and subsequent development of cardiometabolic disease risk factors. Findings from this investigation should inform both the fields of substance use and cardiovascular research about subsequent risks of cocaine ingestion during pregnancy in offspring. PUBLIC HEALTH RELEVANCE: This study will provide important latency affect analysis of the long-term cardiovascular health implications among in utero cocaine exposed children. Findings from this investigation should inform both the fields of substance use and cardiovascular research about subsequent risks of cocaine ingestion during pregnancy in offspring.

描述（由申请人提供）：该K01奖将允许候选人Sarah Messiah博士获得成为独立调查员所需的技能，知识和经验。使用迈阿密产前可卡因研究（MFCS，Emmalee Bandstra博士，首席研究员）的数据，弥赛亚博士将研究16-18岁非洲裔美国儿童的子宫可卡因暴露，人体测量量的增长和心脏代谢疾病风险因素的发展之间的关系。 MPC通过青春期早期收集了11多名婴儿及其母亲/替代护理人员的多域数据波，现在正在16 -18岁时启动2个额外的数据收集波。拟议的指导研究具有三个具体的目的：（1）在城市，非洲裔美国儿童和青少年中，纵向比较人体测量指标（身高，体重，体重，体重指数，腰围和身体成分），他们使用先前建立和良好的niDA niDA niDA niDA niDA niDA共生；（2）在城市，非洲裔美国青少年中比较了心脏代谢危险因素（禁食葡萄糖，胰岛素，脂质，CRP，血压），他们使用先前建立且特征良好的NIDA群体在产前或未在产前暴露于可卡因； and (3) To determine the specific effects of both prenatal and postnatal exposures of cocaine in a repeated measures multivariate analysis, controlling for effect modifiers (nicotine, alcohol and marijuana exposure, stress, anxiety and depression in children and mothers) on: (a) Overweight and obesity, (b) Underweight, and (c) > 3 cardiometabolic risk factors (often referred to as "metabolic综合征”）。为了实现这项研究和她的职业发展目标，弥赛亚博士将遵循迈阿密米勒大学医学院的职业发展计划，旨在提供4种核心竞争力的知识，技能和经验（HFE疾病过程，尤其是可卡因暴露术中的纵向/潜在的纵向/潜在的增长方法，胚胎态疾病和成人疾病的疾病和成人疾病的疾病和成人疾病均涉及儿童疾病。拟议的研究的广泛长期目标是阐明因果关系和非因果关系，特别关注子宫内可卡因暴露可能如何改变人体测量值的发生和轨迹，以及随后的心脏代谢疾病风险因素的发展。这项调查的结果应介绍物质使用和心血管研究领域，以了解后代怀孕期间可卡因摄入的风险。公共卫生相关性：这项研究将提供重要的潜伏期影响子宫内可卡因儿童中长期心血管健康影响的分析。这项调查的结果应介绍物质使用和心血管研究领域，以了解后代怀孕期间可卡因摄入的风险。