Integrating neural and momentary assessment of parenting, arousal, and adolescent substance use

整合对育儿、唤醒和青少年物质使用的神经和瞬时评估

• 批准号: 10729938
• 负责人: Tara M Chaplin
• 金额: $ 12.52万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729938
• 关键词: 16 year old; Address; Adolescence; Adolescent; Adult; Age; Arousal; Cellular Phone; Child Rearing; Collection; Conflict (Psychology); Data; Data Collection; Development; Ecological momentary assessment; Educational process of instructing; Emotional; Emotions; Environment; Family; Female Adolescents; Functional Magnetic Resonance Imaging; Funding; Future; Gender; Heart Rate; Independent Scientist Award; Intervention; Intervention Studies; Investigation; Laboratories; Lead; Life; Longitudinal cohort; MRI Scans; Magnetic Resonance Imaging; Measures; Methods; Modeling; National Institute of Drug Abuse; Neurobiology; Parents; Process; Public Health; Reporting; Research; Rewards; Risk; Risk Behaviors; Risk Factors; Sampling; Science; Scientist; Sex Differences; Time; Training; United States National Institutes of Health; Youth; adolescent substance use; boys; career; design; follow-up; girls; high-risk adolescents; improved; multilevel analysis; neural; prevent; programs; recruit; research study; response; sensor; sex; substance use; substance use prevention; therapy development; wearable sensor technology

Project Summary/Abstract Adolescence is a risk period for increases in substance use (SU). Also, SU rates are increasing for adolescent girls, however sex differences in SU are under-studied. Given the public health problem of adolescent SU, it is critical to identify risk factors for SU and use those to develop accessible gender-sensitive SU preventions. One risk factor for SU is maladaptive parenting. Maladaptive parenting may lead to lead SU through its effects on adolescent emotion and reward-related arousal. My NIH-funded line of developmental research, using laboratory and fMRI methods, has found that maladaptive parenting predicts heightened negative emotional arousal for girls and heightened reward arousal for boys, which predicts increased SU (R01-DA033431). However, these lab/MRI findings are limited in that they do not capture real-world proximal associations among parenting, arousal, and SU. My other line of research has found that interventions that improve parenting can prevent adolescent SU (R01-DA052427). However, parenting interventions are limited in that they are not accessible to all parents and do not address momentary real-world parenting. To address this, the proposed K02 Award would provide me with protected time (through release from teaching and administrative duties) and advanced training in momentary science to transform my lines of developmental and intervention research and to transform those scientific fields. The K02 would provide me with hands-on training in conceptual models of ecological momentary assessment (EMA), EMA collection and analyses, fMRI-EMA analyses, sensor integration, and ecological momentary intervention (EMI) development. With this training, I will more fully characterize sex differences in mechanisms of parenting effects on SU and will identify targets for accessible smart-phone delivered momentary parenting-focused interventions to prevent SU. The K02 study would add a 4 week EMA of parenting, adolescent emotion and reward arousal, and SU to my ongoing lab/MRI R01 study with a subset of 75 adolescents at their 3 year follow-ups (at age 15-16, during escalation of SU). I will use this EMA to understand momentary parenting, arousal, and SU associations (by sex) in real world contexts. I will leverage already collected fMRI data from the R01 when youth were age 12- 13 to examine whether adolescents’ earlier fMRI responses moderate momentary EMA associations. This K02 Award would enhance my research by allowing investigation of interplay between neurobiological risk and sensitivity to momentary real-world parenting behaviors. The K02 study will benefit from the already recruited and MRI scanned youth in the R01 study who are being followed through the R01 for 3 years with extensive longitudinal assessments. The K02 Award will allow hands-on training in EMA to transform my program of research, pilot data for a R01 application to conduct a large EMA-fMRI study, and training and pilot data for me to develop momentary interventions that reduces negative parenting (or adolescent arousal in response to parenting) in the moment in real world settings to prevent adolescent SU.

项目概要/摘要 青春期是物质使用 (SU) 增加的危险时期，而且物质使用率也在增加。 青春期女孩，但考虑到公共卫生问题，SU 中的性别差异尚未得到充分研究。 青少年 SU，识别 SU 的危险因素并利用这些因素来培养对性别问题有敏感认识的人是至关重要的 SU 预防。SU 的危险因素之一是适应不良的养育方式。适应不良的养育方式可能会导致 SU。 通过它对青少年情绪和奖励相关的唤醒的影响，我的国家卫生研究院资助的发展线。 使用实验室和功能磁共振成像方法的研究发现，适应不良的养育方式可预测哮喘 女孩的负面情绪唤起和男孩的呼吸分析仪奖励唤起，这预示着 SU 会增加 (R01-DA033431) 然而，这些实验室/MRI 结果是有限的，因为它们不能捕获现实世界的近端。 我的另一项研究发现，干预措施可以促进养育、唤醒和 SU 之间的关联。 改善养育方式可以预防青少年 SU (R01-DA052427) 然而，养育干预措施是有限的。 因为它们并不是所有父母都能接触到的，也不能解决暂时的现实世界养育问题。 为了解决这个问题，拟议的 K02 奖将为我提供受保护的时间（通过从 教学和行政职责）和瞬时科学的高级培训，以改变我的路线 K02 将为我提供发展和干预研究以及改变这些科学领域的机会。 通过生态瞬时评估 (EMA)、EMA 收集和概念模型的实践培训 分析、fMRI-EMA 分析、传感器集成和生态瞬时干预 (EMI) 开发。 通过这次培训，我将更全面地描述养育方式对SU和SU的影响机制中的性别差异。 将确定可访问智能手机的目标，提供以育儿为重点的临时干预措施，以防止 SU。K02 研究将增加 4 周的育儿、青少年情绪和奖励唤起的 EMA，以及 SU。 我正在进行的实验室/MRI R01 研究对 75 名青少年进行了 3 年随访（15-16 岁，在 SU 的升级）。我将使用此 EMA 来理解瞬时养育、唤醒和 SU 关联（通过 性）在现实世界中，我将利用青少年 12 岁时从 R01 收集的功能磁共振成像数据。 13 检查青少年早期的功能磁共振成像反应是否会调节短暂的 EMA 关联。 这个 K02 奖将通过调查之间的相互作用来加强我的研究 K02 研究将受益于神经生物学风险和对瞬时现实养育行为的敏感性。 来自 R01 研究中已招募并接受 MRI 扫描的青少年，他们正在整个 R01 中被跟踪 为期 3 年的广泛纵向评估将允许 EMA 进行实践培训。 转变我的研究计划、R01 应用程序的试点数据以进行大型 EMA-fMRI 研究，以及 为我提供培训和试点数据，以制定减少消极养育方式的临时干预措施（或 现实世界中的青少年对养育的反应），以防止青少年 SU。