Resource Center for Alzheimer's and Dementia Research in Asian and Pacific Americans

亚太裔美国人阿尔茨海默病和痴呆症研究资源中心

基本信息

批准号：
10730059
负责人：
William Tzu-lung Hu
金额：
$ 75.88万
依托单位：
RUTGERS BIOMEDICAL AND HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10730059
关键词：
Acculturation Adult Age Years Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk American Area Asia Asian Asian Americans Asian Indian Atherosclerosis Award Behavior Behavioral Biomedical Research COVID-19 pandemic Career Mobility Caring Cause of Death Chinese Chinese American Cities Cognition Cognitive Cohort Studies Common Data Element Communities Complement Country Data Data Set Dementia Development Diagnosis Discipline Discrimination Disparate Disparity East Asian Economics Education Effectiveness Elderly Ethnic Origin Ethnic Population Face Faculty Foundations Funding Goals Growth Health Health Policy Health Promotion Immigration Institution Internships Knowledge Language Lead Leadership Learning Linguistics Low Prevalence Measurement Mediator Medicare claim Mentors Meta-Analysis Methodology Methods Minority Minority-Serving Institution Mission Modeling Native Hawaiian or Other Pacific Islander New Jersey New York New York City Outcome Participant Peer Review Personal Satisfaction Persons Phase Pilot Projects Policy Maker Population Population Study Prevalence Prospective Studies Publications Recording of previous events Research Research Personnel Resources Scientist Social isolation South Asian Stress Subgroup Surveys System Testing Time anti-Asian apprenticeship brain health career career development cohort data sharing dementia care education research equity, diversity, and inclusion experience health equity health inequalities improved innovation insight method development metropolitan multidisciplinary next generation outreach pandemic disease prospective psychosocial racial population racism recruit social social culture social stigma success tool

项目摘要

ABSTRACT Asian and Pacific Americans (APAs) have undergone the greatest growth among all racial/ethnic groups in the U.S. between 2000 and 2020. In the New York City/New Jersey (NYC/NJ) area, older (65+) Asian Indian and Chinese American populations have increased by 73% and 74% over the past ten years. While claims-based studies in the U.S. have previously suggested lower prevalence of Alzheimer’s disease (AD) and related dementias (ADRD) in older APAs, this finding may have resulted from underdiagnosis associated with not having culturally and linguistically appropriate tools, clinicians, or systems. Older APAs with AD/ADRD in the U.S. thus face both the problem of under-diagnosis and under-provision of care as a whole, even as great disparities exist within and between APA subgroups. What’s more, the COVID-19 pandemic and the associated anti-Asian discrimination brought greater social isolation to older Chinese and non-Chinese APA adults over the past three years than other groups. These factors together formed the foundation of the Resource Center for Alzheimer’s and Dementia Research in Asian and Pacific Americans (RCASIA) with missions of 1) increasing scientists underrepresented in AD/ADRD-related Behavioral, Social, and Economic Research biomedical research through innovative models of mentoring and community interaction; 2) advancing the rigor and impact of AD/ADRD pilot studies in older APAs through Common Data Elements and data-sharing; 3) serving as a national resource for linguistically/culturally tested and validated tools to assess cognition, function, and AD/ADRD care in APA populations. Focusing on the theme of People, Culture, Place, Time, RCASIA will leverage strong institutional support and relationships to solicit pilot applications from Early Stage Investigators (ESIs). We will actively engage and encourage applications from ESIs at NYC/NJ-based Minority Serving Institutions through pre-application RCASIA internships and partnership commitments from large funded studies prospectively recruiting disaggregated older APAs. Scientist mentoring will occur in the Research Education Component (co-led by a returning REC Core Lead and a newly recruited yet established AD/ADRD Education/Psychosocial Core Lead) involving mentoring/method-based Pods and ethnicity-based Teams. REC will be supported by the Leadership & Administrative Core, the Measurement & Analytical Core, and Community Liaison & Recruitment Core in selecting each year’s class of RCASIA Scientists, enhancing multi-generational method and career development in Pods, conducting transdisciplinary engagement with Community & Lived Advisors in Teams, and evaluating the outcomes of Scientists, effectiveness of the Pod/Team model, impact of Common Data Elements and data sharing, and long-term relationships between RCASIA and funded Scientists. Returning and new faculty’s commitment to diversity, equity, inclusion, and access and APA brain health will contribute to RCASIA’s goal of becoming the epicenter for AD/ADRD-related Behavioral, Social, and Economic Research in older APA populations.

抽象的在美国所有种族/族裔群体中，亚裔和太平洋裔美国人 (APA) 的增长最快 2000 年至 2020 年间的美国。在纽约市/新泽西州 (NYC/NJ) 地区，老年（65 岁以上）亚裔印度人和过去十年，美国华裔人口增长了 73% 和 74%。美国的研究此前表明阿尔茨海默病 (AD) 及相关疾病的患病率较低老年 APA 中的痴呆症 (ADRD)，这一发现可能是由于与非拥有文化和语言上合适的工具、登山者或具有 AD/ADRD 的旧 APA。因此，美国整体上面临着诊断不足和护理提供不足的问题，即使 APA 亚组内部和之间存在巨大差异，此外，COVID-19 大流行和 APA 亚组之间也存在巨大差异。相关的反亚裔歧视给老年华人和非华人 APA 带来了更大的社会孤立这些因素共同构成了过去三年中成年人比其他群体的基础。亚太裔美国人阿尔茨海默病和痴呆症研究资源中心 (RCASIA) 1) 增加在 AD/ADRD 相关行为、社会和经济方面代表性不足的科学家的使命通过创新的指导和社区互动模式进行生物医学研究2) 通过通用数据元素提高旧 APA 中 AD/ADRD 试点研究的严谨性和影响力数据共享；3）作为经过语言/文化测试和验证的评估工具的国家资源 APA 人群的认知、功能和 AD/ADRD 护理重点关注人、文化、地点、时间，RCASIA 将利用强大的机构支持和关系来征求试点申请我们将积极参与并鼓励 ESI 的申请。通过预申请 RCASIA 实习和合作，为纽约/新泽西州的少数族裔服务机构提供服务大型资助研究的承诺，前瞻性地招募分类的老年科学家。指导将在研究教育部分进行（由回归的 REC 核心领导和新任 REC 共同领导）招募尚未建立的 AD/ADRD 教育/心理社会核心领导），涉及指导/基于方法 Pod 和基于种族的团队将得到领导和管理核心的支持。衡量和分析核心，以及社区联络和招聘核心，用于选择每年的班级 RCASIA 科学家，加强 Pod 中的多代方法和职业发展，进行与团队中的社区和生活顾问进行跨学科互动，并评估结果科学家、Pod/团队模型的有效性、通用数据元素和数据共享的影响，以及 RCASIA 与受资助的归国科学家之间的长期关系以及新教师的承诺。多样性、公平性、包容性和可及性以及 APA 大脑健康将有助于实现 RCASIA 成为老年 APA 人群中 AD/ADRD 相关行为、社会和经济研究的中心。