Diabetes and Endocrinology Research Center

糖尿病与内分泌研究中心

• 批准号: 7902308
• 负责人: Gordon Campbell Weir
• 金额: $ 20.1万
• 依托单位: JOSLIN DIABETES CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7902308
• 关键词: Animal Model; Animals; Area; Atherosclerosis; Attention; Basic Science; Bioinformatics; Biological Assay; Biological Models; Caring; Cell physiology; Clinical Research; Clinical Treatment; Collaborations; Complex; Continuing Education; Data; Development; Diabetes Mellitus; Discipline; Disease; Education; Educational workshop; Endocrinology; Environment; Equipment; Evaluation; Exercise; Feasibility Studies; Flow Cytometry; Fostering; Functional disorder; Genetic; Genomics; Grant; Human; Informatics; Institution; Knowledge; Laboratories; Lead; Measurement; Metabolic Diseases; Microscope; Microscopy; Mission; Molecular; Obesity; Pathogenesis; Patients; Physiological; Physiology; Play; Postdoctoral Fellow; Prevention; Process; Productivity; Proteomics; Reagent; Research; Research Infrastructure; Research Personnel; Role; Sampling; Series; Services; Students; Technical Expertise; Translations; Visit; Work; base; diabetes management; innovation; laser capture microdissection; medical schools; mouse model; professor; programs; tool; web site

During the past 20 years, the DERC, with its Core Laboratories, Enrichment Program and support for Pilot and Feasibility (P&F) studies, has played a major role in fostering expansion in the scope and intensity of research at the Joslin Diabetes Center and Harvard Medical School. The DERC has provided critical infrastructure for both basic and clinical research. It is not surprising, therefore, that over this period the research productivity of Joslin has expanded enormously. The Joslin DERC has evolved considerably over the past grant period. The Scientific Base has moved into new cutting-edge research areas and maintained the synergistic relationship between basic and translational work, which has already led to a new clinical treatment. The DERC Core Laboratories have been restructured. The Molecular Cluster containing the Genetics, Genomics and Proteomics Cores has added a new Bioinformatics Core, which will coordinate the challenge of handling massive amounts of data with the most up-to-date informatics tools and expertise. The Flow Cytometry Core has increased the range of its services with new equipment including a largeparticle sorter, which opens new research avenues. The Advanced Microscopy Core now can offer service on a Laser Capture Microdissection Microscope. The Special Assay Core has added many new assays and is able to handle an ever-increasing volume of samples. The Animal Physiology Core provides critical physiological measurements for the many mouse models created at Joslin. The management of the DERC is now much more efficient thanks to Website Services, which facilitates ordering, tracking of service, and chargeback mechanisms for the Cores; and handles the P&F proposal process and the Enrichment Program. The P&F study program continues to be very successful in supporting young investigators and innovative research at Joslin and other Harvard research institutions. The Enrichment Program continues to enhance the research environment for students, post-doctoral fellows and investigators by supporting a valuable array of academic exercises and visiting speakers.

在过去的 20 年里，DERC 及其核心实验室、丰富项目和对试点的支持 和可行性（P＆F）研究，在促进扩大范围和强度方面发挥了重要作用 乔斯林糖尿病中心和哈佛医学院的研究。 DERC 提供了关键的 基础和临床研究的基础设施。因此，在此期间， 乔斯林的研究生产力得到了极大的提高。 Joslin DERC 已经取得了长足的发展 过去的补助期。科学基地进入新的前沿研究领域并保持 基础工作和转化工作之间的协同关系，已经导致了新的临床 治疗。 DERC核心实验室已经重组。分子簇包含 遗传学、基因组学和蛋白质组学核心增加了一个新的生物信息学核心，它将协调 使用最新的信息学工具和专业知识处理大量数据的挑战。 流式细胞术核心通过包括大颗粒在内的新设备扩大了其服务范围 排序器，开辟了新的研究途径。高级显微镜核心现在可以提供服务 在激光捕获显微切割显微镜上。特殊检测核心添加了许多新的检测方法 能够处理不断增加的样品量。动物生理学核心提供了关键 对乔斯林创建的许多小鼠模型进行生理测量。 DERC的管理 得益于网站服务，现在效率更高了，网站服务方便了订购、服务跟踪和 核心的退款机制；并处理 P&F 提案流程和浓缩 程序。 P&F 研究计划在支持年轻研究者和 乔斯林和其他哈佛大学研究机构的创新研究。丰富计划继续 通过支持学生、博士后研究员和研究人员改善研究环境 一系列有价值的学术练习和客座演讲者。