Quantitative MRI analysis method for longitudinal assessment of knee OA

膝关节骨关节炎纵向评估的定量MRI分析方法

• 批准号: 7784808
• 负责人: JEFFREY W DURYEA
• 金额: $ 40.05万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7784808
• 关键词: Address; Area; Bone Cysts; Bone Marrow; Cartilage; Clinical; Color; Computer software; Cyst; Data; Degenerative polyarthritis; Disease Progression; Edema; Enrollment; Evaluation; Image; Image Analysis; Imagery; Incidence; Industry; Knee; Knee Osteoarthritis; Knee joint; Laboratories; Magnetic Resonance Imaging; Measurement; Measures; Methodology; Methods; Metric; Modification; Organ; Pain; Physiologic pulse; Printing; Process; Process Measure; Public Health; Reader; Research; Resolution; Scanning; Side; Slice; Software Tools; Specific qualifier value; Structure; Surface; System; Techniques; Testing; Thick; Three-Dimensional Image; Time; United States National Institutes of Health; Work; articular cartilage; base; cohort; follow-up; image processing; image registration; improved; morphometry; public health relevance; software development; statistics; success; tool

DESCRIPTION (provided by applicant): Magnetic resonance imaging (MRI) offers direct three dimensional (3D) visualization of the articular cartilage in the knee joint. New high-field three-Tesla (3T) MRI scanners and specialized pulse sequences can provide images with excellent spatial resolution and high contrast, which show the cartilage and other structures of the knee in great detail. These new techniques are ideal for the application of image processing software to segment (identify and outline) cartilage plates on MRI slices for the quantitative assessment of osteoarthritis (OA) progression. Several academic and industry affiliated research groups have developed software tools to segment the cartilage plates on knee MRI scans. However measures derived from the full cartilage plate or even specified subregions can be relatively insensitive to change. We propose to test the hypothesis that an analysis based on comparing local regions of the knee cartilage will be more responsive than global measures of cartilage morphometry for detecting knee OA changes. We will use a software tool developed in our laboratory to segment the articular cartilage on knee MRI image sets. 3D registration software will be used to align baseline and follow-up segmented scans. Once the baseline and follow-up segmented images are registered (aligned) the technique will measure volume change in a region in close proximity to a known cartilage area of thinning. We will also develop and validate new quantitative metrics based on measurements of bone marrow edema (BME), bone cysts, and osteophyte volume. Our project will use data and images from the osteoarthritis Initiative (OAI), a large National Institutes of Health (NIH) study with approximately 4,800 enrolled subjects subdivided into three groups: the Incidence Cohort, the Progression Cohort, and the Control Cohort. A subset of 400 subjects from the Progression Cohort will be used to test our hypotheses. Our existing analysis software will be further developed to facilitate the aims of the study. PUBLIC HEALTH RELEVANCE: This project will address public health concerns by validating an improved technique for evaluating osteoarthritis of the knee. The work will contribute to the public health indirectly by assisting others in developing and evaluating OA therapies.

描述（由申请人提供）：磁共振成像（MRI）提供了直接的三维（3D）可视化膝关节中关节软骨的可视化。新的高场三台拉（3T）MRI扫描仪和专门的脉冲序列可以提供具有出色的空间分辨率和高对比度的图像，从而显示了膝盖的软骨和其他膝盖的其他结构。这些新技术非常适合在MRI切片上应用图像处理软件在MRI切片上进行细分（识别和概述）软骨，以定量评估骨关节炎（OA）进展。几个学术和行业的研究小组开发了软件工具，以分割膝盖MRI扫描的软骨板。但是，源自整个软骨板甚至指定子区域的措施可能对变化相对不敏感。我们建议检验以下假设：基于比较膝盖软骨的局部区域的分析将比全球软骨形态计量学测量更快，以检测膝盖OA变化。我们将使用在实验室中开发的软件工具来分割膝盖MRI图像集上的关节软骨。 3D注册软件将用于对齐基线和后续分段扫描。一旦将基线和随访分段图像注册（对齐），该技术将在靠近已知的稀疏软骨区域的区域中测量体积变化。我们还将基于骨髓水肿（BME），骨囊肿和骨质植物体积的测量来开发和验证新的定量指标。我们的项目将使用骨关节炎倡议（OAI）的数据和图像，这是一项大型国家卫生研究院（NIH）研究，大约有4,800名招募的受试者分为三组：发病率队列，进展队列和对照组。来自进展队列的400名受试者的子集将用于检验我们的假设。我们现有的分析软件将进一步开发，以促进研究的目标。 公共卫生相关性：该项目将通过验证评估膝盖骨关节炎的改进技术来解决公共卫生问题。这项工作将通过协助其他人开发和评估OA疗法来间接地为公共卫生做出贡献。