Animal Models for the Prevention and Treatment of Drug Abuse

预防和治疗药物滥用的动物模型

基本信息

批准号：
7802053
负责人：
Marilyn E. Carroll
金额：
$ 13.9万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7802053
关键词：
Adolescent Adult Advocacy Affect Animal Model Animals Behavior Behavioral Biological Cocaine Development Dose Drug abuse Economics Educational Activities Educational process of instructing Elasticity Endogenous Factors Environmental Risk Factor Female Food Funding Future Gender Goals Grant Heroin Hormonal Human Impulsive Behavior Impulsivity Individual Individual Differences Instruction Intervention Luteal Phase Macaca mulatta Magnetic Resonance Imaging Measures Menstrual cycle Mentorship Methamphetamine Modeling Monkeys National Institute of Drug Abuse Neurobiology Performance Pharmaceutical Preparations Pharmacological Treatment Phase Phase Transition Phencyclidine Phenotype Predisposition Prevention Procedures Progress Reports Protocols documentation Publications Rattus Research Rewards Risk Route Saccharin Science Self Administration Self-Administered Self-control as a personality trait Senior Scientist Award Sex Functioning Smoke Smoking Solutions Students Time Training Treatment Efficacy Treatment outcome Wages Water addiction base discounting drinking drug of abuse drug reward drug seeking behavior excessive behavior innovation male non-drug nonhuman primate novel reinforcer research study sex success treatment strategy university student

项目摘要

DESCRIPTION (provided by applicant): The objective of this K05 application is to obtain salary support for release time from teaching and administrative duties not directly related to research. This would increase time allocated to research from 40% before the K05 to 75-90. An overview of the candidate's 31-year background in drug abuse research is provided including a list of publications, presentations, a citation analysis, research funding, and mentorship of students, science advocacy, and educational activities. Short-and-long-term research plans that will be implemented with released time are discussed. Specific activities planned to sustain outstanding research performance, blending of past and future goals, the likelihood of continuing successful contributions, and plans to obtain and provide instruction on the responsible conduct of science are also discussed. A progress report describes accomplishments made in the first 4 years of this K05 award 2002-2006. The research plan consists of 2 continuing R01 projects that have been funded by NIDA for over 20 years, a new R01 (PI) that is under review, and a P20 application (Co-Pi) that is under review. The first grant is a nonhuman primate model to study sex, phase of menstrual cycle, and impulsivity as factors that affect the Vulnerability to drug abuse and to implement innovative behavioral and pharmacological treatments for drug abuse. The overall hypothesis is that these vulnerability factors will predict reinforcing efficacy and treatment success. The second grant will examine behavioral and pharmacological interventions in rats selected for several vulnerable behaviors. These factors will be compared during critical transition phases of addiction, acquisition, escalation, and reinstatement. The hypothesis is that a predisposition (individual differences) for excessive behavior directed toward novel and rewarding nondrug activities increases vulnerability to drug abuse and responsiveness to treatment. The third proposed grant, to be conducted in adolescent rats, is focused on factors underlying drug abuse. The overall hypothesis is that adolescent animals are more impulsive and susceptible to hormonal influences on drug seeking behavior than adults. The fourth proposed grant, a P20, would consist of an animal project that will parallel and inform two human projects involving cocaine abusers and college students varying in impulsive behavior. The basic theme is how, impulsivity is related to drug abuse, and MR imaging will be used in rats and monkeys to compare neurobiological and behavioral phenotypes. Species, gender, several drugs of abuse, routes of administration, and phases of addiction will be compared. The results will allow for identification of biological, behavioral, and environmental factors leading to recognition of individuals at risk for drug abuse, and the experimental interventions used with these models will inform prevention and treatment strategies for humans.

描述（由申请人提供）：此 K05 申请的目的是获得与研究不直接相关的教学和行政职责的工资支持。这将使分配给研究的时间从 K05 之前的 40% 增加到 75-90%。提供了候选人 31 年药物滥用研究背景的概述，包括出版物、演示文稿、引文分析、研究经费和学生指导、科学宣传和教育活动的列表。讨论了将在发布时间内实施的短期和长期研究计划。还讨论了为维持杰出研究表现而计划的具体活动、过去和未来目标的结合、持续成功贡献的可能性，以及获得和提供负责任的科学行为指导的计划。进度报告描述了 2002-2006 年 K05 奖前 4 年取得的成就。该研究计划包括两个由NIDA资助20多年的持续R01项目、一个正在审查的新R01（PI）和一个正在审查的P20申请（Co-Pi）。第一项拨款是非人类灵长类动物模型，用于研究性别、月经周期阶段和冲动等影响药物滥用脆弱性的因素，并针对药物滥用实施创新的行为和药物治疗。总体假设是，这些脆弱因素将预测增强疗效和治疗成功。第二笔拨款将研究针对几种易受伤害行为的老鼠的行为和药理学干预措施。这些因素将在成瘾、习得、升级和恢复的关键过渡阶段进行比较。该假设认为，针对新颖且有益的非药物活动的过度行为倾向（个体差异）会增加药物滥用的脆弱性和对治疗的反应性。第三项拟议拨款将在青春期大鼠中进行，重点关注药物滥用的潜在因素。总体假设是，青春期动物比成年人更冲动，更容易受到激素对药物寻求行为的影响。第四项拟议拨款是 P20，将包括一个动物项目，该项目将与两个涉及可卡因滥用者和冲动行为各异的大学生的人类项目平行并为其提供信息。基本主题是冲动与药物滥用之间的关系，以及磁共振成像将用于大鼠和猴子，以比较神经生物学和行为表型。将比较物种、性别、几种滥用药物、给药途径和成瘾阶段。研究结果将有助于识别生物、行为和环境因素，从而识别出有药物滥用风险的个体，并且与这些模型一起使用的实验干预措施将为人类的预防和治疗策略提供信息。