Clinical Resources Core

临床资源核心

• 批准号: 10721316
• 负责人: Robert Hal Scofield
• 金额: $ 61.68万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10721316
• 关键词: Acceleration; Acute; Address; Adopted; American Indians; Area; Arthritis; Autoimmunity; Basic Science; COVID-19 pandemic; COVID-19 testing; COVID-19 therapeutics; COVID-19 vaccine; Cardiovascular Diseases; Centers of Research Excellence; Certification; Cherokee Indian; Child Health; Childhood; Chronic; Clinical; Clinical Data; Clinical Informatics; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials Network; Collaborations; Community Outreach; Contract Services; Contracts; Data; Data Analyses; Databases; Degenerative polyarthritis; Development; Diabetes Mellitus; Disease; Disease Outcome; Dissemination and Implementation; Effectiveness; Ensure; Feasibility Studies; Funding; Growth; Health; Human Resources; Human Subject Research; Individual; Informatics; Infrastructure; Inpatients; Institution; Institutional Review Boards; Investigation; Investments; K-Series Research Career Programs; Learning; Life Expectancy; Malignant Neoplasms; Mediation; Medical; Mentors; Minority Groups; National Center for Advancing Translational Sciences; Native American Research Center for Health; Obesity; Oklahoma; Outcome; Participant; Patient Recruitments; Patients; Phase; Play; Population; Process; Protocols documentation; RADx Underserved Populations; Registries; Reproducibility; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Role; Rural; Rural Minority; Sampling; Scientist; Site; System; Therapeutic Intervention; Translational Research; Tribes; Underrepresented Minority; United States Indian Health Service; United States National Institutes of Health; Variant; Viral; West Virginia; Work; biobank; career; clinical infrastructure; cohort; community engagement; community organizations; coronavirus disease; data warehouse; human subject; implementation research; improved; informatics infrastructure; innovation; member; minority communities; minority health disparity; new growth; population health; programs; recruit; repository; research facility; response; rural health disparities; sample collection; satisfaction; therapeutic vaccine; translational scientist; tribal community; vaccine hesitancy

Although some improvement has been made since the Oklahoma Shared Clinical and Translational Resources (OSCTR) initiation, Oklahoma remains consistently in or near the bottom 10% of states for the overall health of its population. Oklahoma’s residents disproportionately suffer from chronic health problems, such as obesity, diabetes, cardiovascular disease, and arthritis/autoimmunity. Oklahomans have a life expectancy of 4 years shorter than the average US citizen, while American Indians have a life expectancy of more than 7 years shorter than other groups within the US. With high percentages of rural (34%) and tribal (16%) populations, Oklahoma has unique challenges and opportunities to implement clinical and translational research (CTR) projects and dissemination and implementation research to improve health and disease outcomes. The Clinical Resources (ClinRes) Core of the OSCTR has built a centralized system to support human subjects research focused on these issues. The Core provides clinical research facilities and staff to assist with participant recruitment and regulatory approvals, a CAP-certified Biorepository that has allowed the OSCTR to adopt or establish registries, repositories, and cohorts to assist investigators in obtaining and utilizing high-quality samples to support their research efforts, and infrastructure for accessing de-identified patient data to support clinical research projects. These efforts have allowed the Core to support the careers of multiple CTR investigators, including researchers who are members of the under-represented minority communities in the state. The ClinRes Core will continue to provide this invaluable access to sample collections while supporting the establishment and growth of new repositories focusing on the health issues of greatest concern to our populations, including cancer, diabetes, and arthritis. The ClinRes core will continue to work with the Community Engagement and Outreach (CEO) Core to build on the strong relationships developed with smaller community organizations across the state during the COVID-19 pandemic. Together, these collaborations enhance the overall opportunities of our CTR investigators to expand clinical study and trial access to residents throughout the state to help increase participant diversity and address our rural and minority health disparities. The ClinRes Core will continue to provide junior investigators with essential assistance with institutional IRB applications, protocols, data safety monitoring boards, and other regulatory requirements and will work with the Administrative Core to make access to resources and information more accessible to investigators, clinicians, clinical research staff, and participants through the Gateway to Oklahoma portal. With the CEO Tribal Engagement Unit, we will assist investigators in working with the Indian Health Service and tribal IRBs, ensuring the protection of both individual human subjects and tribal community populations. Finally, we will continue developing and supporting resources to grow our clinical research informatics capacity to facilitate local and national research efforts.

尽管自俄克拉荷马州共享临床和转化资源以来已经取得了一些进步 (OSCTR) 启动后，俄克拉荷马州的整体健康状况始终处于或接近垫底的 10% 俄克拉荷马州的居民不成比例地患有肥胖等慢性健康问题， 患有糖尿病、心血管疾病和关节炎/自身免疫性疾病的俄克拉荷马人的预期寿命为 4 年。 比美国公民的平均寿命短，而美洲印第安人的预期寿命超过 7 年 农村人口（34%）和部落人口（16%）比例较高， 俄克拉荷马州在实施临床和转化研究 (CTR) 方面面临着独特的挑战和机遇 旨在改善健康和疾病结果的项目以及传播和实施研究。 资源 (ClinRes) OSCTR 核心建立了一个集中系统来支持人类受试者研究 该核心专注于这些问题，提供临床研究设施和人员来协助参与者。 招募和监管批准，经过 CAP 认证的生物样本库，允许 OSCTR 采用或 建立登记处、存储库和队列，以协助研究人员获取和利用高质量的 支持他们的研究工作的样本，以及用于访问去识别的患者数据以支持的基础设施 这些努力使核心能够支持多个 CTR 的职业生涯。 调查人员，包括属于代表性不足的少数族裔社区成员的研究人员 ClinRes Core 将继续提供对样本集合的宝贵访问，同时提供支持。 建立和发展新的知识库，重点关注我们最关心的健康问题 ClinRes 核心将继续与癌症、糖尿病和关节炎等人群合作。 社区参与和外展 (CEO) 核心，以与较小规模的企业建立牢固的关系为基础 在 COVID-19 大流行期间，全州各地的社区组织共同开展这些合作。 增强我们的 CTR 研究人员扩大临床研究和试验覆盖居民的总体机会 在全州范围内帮助增加参与者的多样性并解决我们的农村和少数民族的健康差距。 ClinRes Core 将继续通过机构 IRB 为初级研究人员提供必要的帮助 应用程序、协议、数据安全监控委员会和其他监管要求，并将与 管理核心，使调查人员更容易获取资源和信息， 临床研究人员和参与者通过 Gateway to Oklahoma 门户网站与 CEO Tribal 进行交流。 参与部门，我们将协助调查人员与印第安卫生服务局和部落 IRB 合作， 确保保护个体人类受试者和部落社区人口。 继续开发和支持资源，以提高我们的临床研究信息学能力，以促进 地方和国家的研究工作。