Gastric Cancer Epidemiology Initiative in Central America

中美洲胃癌流行病学倡议

• 批准号: 7920231
• 负责人: Douglas Morgan
• 金额: $ 13.6万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7920231
• 关键词: Address; Adenocarcinoma; Alleles; Area; Asia; Atrophic Gastritis; Biocompatible Materials; Biology; Cancer Etiology; Cancer and Nutrition; Carotenoids; Case-Control Studies; Central America; Cessation of life; Childhood; Chronic; Clinical; Collaborations; Complement Factor H; Computer software; Data; Data Collection; Development Plans; Dietary Factors; Dietary Intervention; Disease; District Hospitals; Enrollment; Environment; Environmental Risk Factor; Epidemiologist; Epidemiology; Europe; Fruit; Future; Gastric Adenocarcinoma; Gastroenterology; General Population; Genetic; Genetic Polymorphism; Genetic Predisposition to Disease; Genotype; Health; Helicobacter Infections; Helicobacter pylori; Hispanics; Honduras; Hypochlorhydria; IL8 gene; Image; Incidence; Inflammation; Inflammatory; Integration Host Factors; Interleukin-10; Interleukin-6; International; Intestinal Metaplasia; Investigation; Knowledge; Latin America; Leadership; Location; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of lung; Measures; Medicine; Mentors; Mentorship; Methods; Modeling; Mucositis; North Carolina; Nutrient; Nutrition Assessment; PTGS2 gene; Patients; Population; Population Study; Positioning Attribute; Predisposition; Prevalence; Public Health Schools; Recruitment Activity; Research; Research Infrastructure; Research Methodology; Research Personnel; Risk; Risk Factors; Sampling; Screening procedure; Serum; Single Nucleotide Polymorphism; Site; Specimen; Specimen Handling; TGFB1 gene; Testing; Training; Translational Research; Universities; Virulence; Virulence Factors; Vitamin A; Vitamin E; base; cancer epidemiology; cancer genetics; career development; case control; cytokine; gastrointestinal; gene environment interaction; genetic epidemiology; improved; intervention program; malignant stomach neoplasm; mortality; novel; nutrition; population based; professor; skills; tool

DESCRIPTION (provided by applicant): Candidate: Douglas Morgan, MD MPH is an assistant professor of Medicine and Gastroenterology at the University of North Carolina. Career Development Plan: the candidate will conduct mentored research and participate in coursework to develop vital skills in translational research and implementation, to develop academic leadership. The candidate will be positioned to become leader in gastric cancer epidemiology in the U.S. and Latin America. Immediate Objective: to acquire expertise in cancer, nutrition, and genetic epidemiology methods with a focus upon gastric cancer. Long-term Objective: to decrease gastric cancer mortality in Latin America and the U.S. Latino population, through an in-depth epidemiology initiative in a high incidence region in Central America. Specific Aims: 1) Delineate the gastric cancer genetic susceptibility of the study population. 2) Determine if the H. pylori cagA virulence moiety is an independent risk factor. 3) Appraise dietary factors associated with gastric cancer in the region. Research Methods: case-control population-based study in Western Honduras, a region of high incidence (39 and 21 per 100K/year, M and F, respectively). Our preliminary data suggests that the region is a distinct epidemiologic niche, with unique gastric cancer genetic and environmental susceptibility. In aim 1, we will determine the host risk proinflammatory cytokine profile (IL-1B, IL-10, TNFa, IL-8). In aim 2, we will delineate the H. pylori and cagA virulence prevalence, and association with gastric cancer. In aim 3, we will assess dietary risk factors. We will construct multivariate models to assess the interaction between genetic, H. pylori and dietary factors, to our knowledge the first such investigation. Cumulative target enrollment is 500 cases and 500 controls. Environment: incident cases are recruited at the sole district hospital in Western Honduras, the site of an established, successful collaboration over the past 4 years. Population-based controls are recruited from villages, in the region. Data reduction and analysis, specimen processing, and specimen banking is within the UNC Center for Gastrointestinal Biology and Disease. Mentorship: primary mentorship will be provided Robert Sandier, MD MPH, a national leader in gastrointestinal cancer epidemiology. Secondary mentorship is facilitated with three successful researchers: an international leader in bacterial and H. pylori virulence (Dr Richard Peek, Vanderbilt University), a nutrition cancer epidemiologist (Dr Jessie Satia, UNC School of Public Health), and a genetic epidemiologist (Dr. Kari North, UNC School of Public Health). Relevance: gastric cancer is the second leading cause of global cancer mortality, important in Latin America, and preventable through initiatives in screening, bacterial eradication, and/or dietary intervention. This study, through systematic epidemiology, will provide detailed etiologic information, to target intervention programs in Latin America and possibly the growing U.S. Latino population.

描述（由申请人提供）：候选人：MD MPH的道格拉斯·摩根（Douglas Morgan）是北卡罗来纳大学医学和胃肠病学助理教授。职业发展计划：候选人将进行指导的研究，并参加课程，以发展转化研究和实施方面的重要技能，以发展学术领导。该候选人将被定位为美国和拉丁美洲胃癌流行病学的领导者。直接目标：获得癌症，营养和遗传流行病学方法的专业知识，重点是胃癌。长期目标：通过在中美洲高发地区的一项深入的流行病学倡议中降低拉丁美洲和美国拉丁裔人口的胃癌死亡率。具体目的：1）描述研究人群的胃癌遗传敏感性。 2）确定幽门螺杆菌CAGA毒力部分是否是独立的危险因素。 3）评估与该地区胃癌相关的饮食因素。研究方法：西部洪都拉斯的基于病例对照的人群研究，这是一个高发病率的地区（分别为每100k/年，M和F，M和F分别为39和21）。我们的初步数据表明，该地区是一个独特的流行病学生态位，具有独特的胃癌遗传和环境敏感性。在AIM 1中，我们将确定宿主风险促炎细胞因子谱（IL-1B，IL-10，TNFA，IL-8）。在AIM 2中，我们将描绘幽门螺杆菌和CAGA毒力的患病率，并与胃癌相关。在AIM 3中，我们将评估饮食危险因素。据我们所知，我们将构建多元模型，以评估遗传，幽门螺杆菌和饮食因素之间的相互作用。累积目标注册为500例和500例对照。环境：事件案件是在洪都拉斯西部的唯一地区医院招募的，这是过去4年中建立，成功合作的地点。从该地区的村庄招募了基于人群的控制。数据减少和分析，标本处理以及标本库是UNC胃肠道生物学和疾病中心。指导：将提供主要指导，Robert Sandier，MD MPH，胃肠道癌流行病学的国家领导者MD。次要指导是由三位成功的研究人员促进的：一位是细菌和幽门螺杆菌毒力的国际领导者（Richard Peek博士，范德比尔特大学），营养癌症流行病学家（UNC公共卫生学院Jessie Satia博士）和遗传学家（Kari North，UNC North，UNC Public Health）。相关性：胃癌是全球癌症死亡率的第二大主要原因，在拉丁美洲很重要，并且可以通过筛查，消除细菌和/或饮食干预措施来预防。通过系统的流行病学，这项研究将提供详细的病因学信息，以针对拉丁美洲以及可能不断增长的美国拉丁裔人口的干预计划。