Microscopy Imaging Center for Research through Observation (MICRO) Core

显微镜成像观察研究中心 (MICRO) 核心

• 批准号: 10712773
• 负责人: Alexander Culley
• 金额: $ 15.88万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712773
• 关键词: Aging; Area; Bacteria; Biological; Biological Sciences; Biology; Biomedical Research; COVID-19 pandemic; COVID-19 pandemic effects; Centers of Research Excellence; Client; Collaborations; Communities; Computers and Advanced Instrumentation; Core Facility; Data; Data Analyses; Education; Educational workshop; Electron Microscope; Electron Microscopy; Elements; Environment; Equipment; Extracellular Matrix Proteins; Faculty; Fluorescent Probes; Fostering; Funding; Goals; Growth; Guidelines; Hawaii; Health; Height; Histology; Human; Image; Image Analysis; Imaging technology; Infrastructure; Institution; Laboratories; Lasers; Leadership; Location; Measures; Mentorship; Microbe; Microbiology; Microdissection; Microscope; Microscopy; Modernization; Outcome; Phase; Preparation; Protocols documentation; Publications; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resolution; Scanning; Scientist; Services; Specimen; Students; Subcellular structure; System; Taxus; Technical Expertise; Techniques; Technology; Tissues; Training; Training Activity; United States National Institutes of Health; Universities; Viral; Visit; Visualization; biological research; career; cost; fluorescence imaging; imaging facilities; instrument; instrumentation; laser tweezer; light microscopy; materials science; member; microbiome; microbiome research; microorganism; microscopic imaging; new technology; novel; optic tweezer; particle; programs; recruit; tool; training opportunity; transmission process; virology; webinar

PROJECT SUMMARY –Microscopy Imaging Center for Research through Observation (MICRO) Advanced microscopy is a fundamental tool in biology that allows scientists to visualize and characterize microbiomes. The Microscopy Imaging Center for Research through Observation (MICRO) Core of the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH) is providing comprehensive imaging instrumentation and technical expertise at the University of Hawaiʻi at Mānoa (UHM) to support research that characterizes microorganisms and their relationship to each other, to host tissues, and to their environment. During Phase 1, the MICRO Core expanded the Biological Electron Microscope Facility by moving into a new laboratory space, adding instrumentation and services. MICRO has the only transmission and scanning electron microscopes (TEM & SEM) in the state of Hawaiʻi supporting biological and biomedical research. The MICRO Core acquired a state-of-the-art confocal laser scanning microscope, and laser microdissection and optical tweezers. Dr. Alexander Culley, an expert in microbiology and virology, will be the Project Leader during Phase 2. One goal will be to modernize and replace aging equipment, add an image analysis workstation, incorporate histology for light microscopy, and develop training modules. An area of focus will be to introduce users to emerging imaging and data analysis techniques, in particular rapidly evolving fluorescence-imaging technologies to advance studies of microorganisms and their microbiomes. Webinars and workshops led by experts in the new technologies will be tailored to the needs of MICRO users. The MICRO Core will continue to be available to researchers across the UHM campus, other local research and educational institutions, and visiting scientists. The MICRO Core will support and broaden the research programs of former, current and newly proposed COBRE Research Project Leaders (RPLs) and their affiliates by providing essential infrastructure and expertise to advance their research and foster collaborations that will positively impact the careers of RPLs and more established investigators. The MICRO Core will foster the growth of the ICEMHH by (i) bringing the Center visibility through its research and training efforts, (ii) keeping its researchers up-to-date on advancing instrumentation and technologies in microscopy and imaging, and (iii) contributing to research capacity.

项目摘要 - 显微镜成像观察研究中心 (MICRO) 先进的显微镜是生物学的基本工具，使科学家能够可视化和表征 微生物组观察研究显微成像中心 (MICRO) 核心 环境微生物组和人类健康综合中心（ICEMHH）正在提供全面的 夏威夷大学马诺阿分校 (UHM) 的成像仪器和技术专业知识可支持 表征微生物及其相互关系、与宿主组织及其与其自身关系的研究 在第一阶段，MICRO Core 通过以下方式扩展了生物电子显微镜设施。 搬进新的实验室空间，增加了 MICRO 唯一的传输仪器和服务。 夏威夷州的扫描电子显微镜（TEM 和 SEM）支持生物和生物医学 MICRO Core 配备了最先进的共焦激光扫描显微镜和激光。 微生物学和病毒学专家 Alexander Culley 博士将担任显微解剖和光学镊子。 第二阶段的项目负责人。一个目标是现代化和更换老化设备，添加图像 分析工作站，纳入光学显微镜组织学，并开发培训模块。 将向用户介绍新兴的成像和数据分析技术，特别是快速发展的技术 荧光成像技术促进微生物及其微生物组的研究。 由新技术专家主持的研讨会将根据 MICRO 用户的需求量身定制。 MICRO Core 将继续向 UHM 校园、其他本地研究和研究人员提供 教育机构和访问科学家将支持和扩大研究范围。 前任、现任和新提议的 COBRE 研究项目负责人 (RPL) 及其附属机构的项目 通过提供必要的基础设施和专业知识来推进他们的研究并促进合作，这将 对 RPL 和更成熟的研究人员的职业产生积极影响 MICRO 核心将促进 通过 (i) 通过其研究和培训工作提高中心的知名度，(ii) 保持 其研究人员了解先进的显微镜和成像仪器和技术的最新动态，以及 (iii) 为研究能力做出贡献。