Integrative Systems Biology Core

综合系统生物学核心

基本信息

批准号：
10713944
负责人：
Thomas Louis LaFramboise
金额：
$ 32.69万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-20 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10713944
关键词：
Barrett Esophagus Barrett&apos s carcinogenesis Cells Clinical Collaborations Communication Complex Comprehensive Cancer Center Computer Analysis Data Data Analyses Data Set Database Management Systems Databases Development Diagnosis Disease Duke Comprehensive Cancer Center Dysplasia Early Diagnosis Ensure Environmental Risk Factor Esophageal injury Etiology Experimental Designs Faculty Formulation Foundations Genes Goals Grant Human Resources Information Dissemination Infrastructure Inherited Injury Institution Investments Leadership Malignant neoplasm of esophagus Manuscripts Metaplasia Methods Molecular Molecular Profiling Multiomic Data Pathway interactions Physiology Positioning Attribute Pre-Clinical Model Predisposition Prevention Program Research Project Grants Reproducibility Research Research Design Research Personnel Research Project Grants Resources Secure Specialized Program of Research Excellence Systems Biology Testing Tissue Model Tissues Training Programs Universities Writing analytical method cancer epidemiology cancer prevention carcinogenesis computer infrastructure data management data sharing design experimental study gastrointestinal genetic epidemiology genome-wide injury and repair innovation large scale data medical schools meetings multiple omics novel programs repaired skills wound healing

项目摘要

PROJECT SUMMARY/ABSTRACT The Integrative Systems Biology Core will interact with all investigators to develop and apply appropriate analysis methods and designs to most efficiently achieve project goals. We will ensure that the experimental data is analyzed appropriately to test the hypotheses relevant to each project. In addition, the Integrative Systems Biology Core will provide infrastructure and oversight for secure management of all study data, working closely with the Bioreagents & Resource Core to facilitate accuracy and completeness of datasets for all projects and investigators. Our specific aims are: (1) To integrate cutting-edge analytic approaches in the design, analysis, and interpretation of experimental studies across projects in our program; and (2) To provide secure and accessible database systems and computational infrastructure to facilitate reliable and reproducible analyses conducted by all program investigators. The Integrative Systems Biology Core leverages faculty and resources in the Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine and the Duke Molecular Physiology Institute. Dr. Thomas LaFramboise will direct the Core, with Dr. Simon Gregory as co-director. The Integrative Systems Biology Core will serve as a centralized resource for all personnel, including the leaders of the three research projects and the Bioreagents & Resource Core. The Core will assist investigators with all facets of design, computational analysis and interpretation. Established as well as novel tailored analytic methods are available to promote scientific discovery for investigators within the Core. Core personnel will interact with investigators in all stages of research, from data management, data analysis, interpretation, writing scientific manuscripts and grants, to dissemination of results. The Core will also facilitate access to secure and accessible database systems, facilitating analysis, discovery and collaboration. The Core will assist all investigators with development, management and reliability of their project data and will also integrate information across databases, such as incorporating clinical and experimental data with biospecimen data as provided by the Bioreagents & Resource Core. The Integrative Systems Biology Core will provide a natural foundation for cross-pollination among the projects and Cores, the Core personnel collaborating with all project investigators and Core directors.

项目概要/摘要综合系统生物学核心将与所有研究人员互动，以开发和应用适当的分析最有效地实现项目目标的方法和设计。我们将确保实验数据进行适当的分析以测试与每个项目相关的假设。此外，综合系统 Biology Core 将为所有研究数据的安全管理提供基础设施和监督，并密切合作与生物试剂和资源核心，以促进所有项目和数据集的准确性和完整性调查人员。我们的具体目标是：（1）将尖端分析方法整合到设计、分析、以及对我们项目中各个项目的实验研究的解释； (2) 提供安全和可访问的数据库系统和计算基础设施，以促进可靠和可重复的分析由所有项目调查员进行。综合系统生物学核心利用师资和资源在凯斯综合癌症中心、凯斯西储大学医学院和杜克分子生理学研究所。 Thomas LaFramboise 博士将与 Simon Gregory 博士一起领导核心项目作为联合导演。综合系统生物学核心将作为所有人员的集中资源，包括三个研究项目以及生物试剂和资源核心的领导者。核心将协助具有设计、计算分析和解释各个方面的研究人员。既成立又新颖定制的分析方法可用于促进核心研究人员的科学发现。核工作人员将在研究的各个阶段与研究人员互动，从数据管理、数据分析、解释、撰写科学手稿和资助、传播结果。核心还将促进对安全且可访问的数据库系统的访问，促进分析、发现和合作。核心将协助所有研究人员进行项目的开发、管理和可靠性数据，还将整合跨数据库的信息，例如整合临床和实验数据包含生物试剂和资源核心提供的生物样本数据。综合系统生物学核心将为项目和核心、核心人员之间的异花授粉提供天然基础与所有项目调查员和核心董事合作。