Neurobiology of Hormone-Mediated Behaviors

激素介导行为的神经生物学

基本信息

批准号：
7861232
负责人：
ANN S. CLARK
金额：
$ 0.99万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-01 至 2010-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7861232
关键词：
Address Affect American Animal Model Arousal Behavior Behavioral Behavioral Assay Blood flow Brain Data Diagnosis Disease Dyspareunia Estrogen Receptors Estrogen Replacements Estrogens Feeling Female Functional disorder Genital system Goals Hormones Hyperalgesia ICI 182780 Knowledge Laboratories Laser-Doppler Flowmetry Lesion Lordosis Measures Mechanics Medial Mediating Neurobiology Nociception Orgasm Pain Pain Disorder Partner in relationship Peripheral Phosphodiesterase Inhibitors Physiological Physiology Preoptic Areas Prevalence Progesterone Receptors Quality of life Rattus Reflex action Research Role Sex Behavior Sex Functioning Sexual Arousal Sexual Dysfunction Testing Time Training Uterus Vagina Woman base improved inhibitor/antagonist male phosphoric diester hydrolase pleasure relating to nervous system research study response

项目摘要

DESCRIPTION (provided by applicant): Sexual dysfunction, including disorders of sexual desire, arousal, orgasm and sexual pain, affects approximately 40% of American women, often with significant consequences on quality of life. Despite the prevalence, the causes of female sexual dysfunction remain poorly understood, and treatments are accordingly limited. Animal models of female sexual function have focused on the mechanics of sexual interaction, e.g., the lordosis reflex, limiting the generalizability of such findings for the understanding of sexual dysfunction in women. The goal of the proposed research is to take advantage of the tractability afforded by animal models, but to extend our analysis to include an integrated assessment of female sexual arousal and nociception; facets of sexual functioning that are applicable to women. Studies in Aim 1 will test the role of the medial preoptic area (mPOA) in sexual arousal in anesthetized female rats. In addition, the effects of inhibitors of phosphodiesterase type 5 (PDE-5) on female sexual functioning will be tested. In Aim 2, the role of peripheral estrogen receptors in vaginal nociception will be tested. The results garnered from these studies will address gaps in knowledge of the physiology of female sexual function that may improve the ability to diagnose and to treat sexual dysfunction in women.

描述（由申请人提供）：性功能障碍，包括性欲，唤醒，性高潮和性痛苦的疾病，会影响约40％的美国女性，通常对生活质量产生重大影响。尽管存在普遍存在，但女性性功能障碍的原因仍然很少了解，因此治疗受到限制。女性性功能的动物模型集中在性相互作用的机制上，例如，洛里森反射，限制了这种发现的普遍性，以理解女性性功能障碍。拟议研究的目的是利用动物模型提供的障碍性，但要扩展我们的分析，以包括对女性性唤醒和伤害感受的综合评估；适用于女性的性功能的方面。 AIM 1中的研究将测试麻醉雌性大鼠性唤醒中内侧前区域（MPOA）的作用。此外，将测试5型磷酸二酯酶（PDE-5）抑制剂对女性性功能的影响。在AIM 2中，将测试周围雌激素受体在阴道伤害感受中的作用。从这些研究中获得的结果将解决女性性功能生理学知识的差距，这可能会提高诊断和治疗女性性功能障碍的能力。