Acupuncture for the Treatment of Insomnia - A Pilot Study

针灸治疗失眠——一项初步研究

• 批准号: 7810329
• 负责人: Ronald M. Glick
• 金额: $ 8.23万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7810329
• 关键词: Accounting; Acupuncture procedure; Adult; Adverse event; Anxiety; Arousal; Behavioral; Blinded; Blood Pressure; Chinese Traditional Medicine; Chronic Insomnia; Clinical; Clinical Trials; Comorbidity; Complementary and alternative medicine; Consultations; Electroencephalography; Equipment and supply inventories; Fatigue; Funding; Hour; Impedance Cardiography; Individual; Intervention; Laboratories; Literature; Measures; Medical; Modality; Moods; Needles; Patient Self-Report; Patients; Photoplethysmography; Physiological; Physiology; Pilot Projects; Placebos; Polysomnography; Protocols documentation; Psychophysiology; Randomized; Reporting; Research Design; Research Support; Severities; Sleep; Sleep Fragmentations; Sleeplessness; Symptoms; Testing; Treatment Protocols; base; depressive symptoms; heart rate variability; indexing; public health relevance; response; stressor; success; trait

DESCRIPTION (provided by applicant): In this R21, we are undertaking a 3-year randomized sham-controlled blinded study of acupuncture for the treatment of chronic insomnia. A secondary aim of the study is to explore the effect of acupuncture on hyperarousal, as measured by both heart rate variability (HRV) and quantitative EEG (QEEG) during polysomnography (PSG). We are requesting supplemental funds to add a 1-hour psychophysiological testing (PPT) protocol at baseline and end-of-intervention (EOI), which fits within the above specific aim. We are proposing to add PPT because: insomnia is associated with hyperarousal; acupuncture can result in a shift from sympathetic to parasympathetic predominance; this will provide us with a potentially useful mechanism to account for the clinical benefit of acupuncture for insomnia and potentially other conditions. Given the prominence of daytime symptoms among insomnia patients, our study would be strengthened by the inclusion of PPT in a laboratory setting. PUBLIC HEALTH RELEVANCE: Insomnia is a common and disabling condition associated with psychiatric and medical comorbidities and often persists despite currently available treatments. Acupuncture has been reported to benefit individuals with insomnia and can decrease hyperarousal. This blinded RCT will investigate the impact of a standardized acupuncture protocol on insomnia, daytime symptoms, and hyperarousal.

描述（由申请人提供）：在此R21中，我们正在进行一项为期3年的随机假手术对照针灸研究，以治疗慢性失眠。该研究的次要目的是探索针灸对高阳极的影响，如心率变异性（HRV）和多个脑电图（PSG）期间的定量EEG（QEEG）所测量。我们要求补充资金在基线和干预终止（EOI）上添加1小时的心理生理测试（PPT）方案，该方案适合上述特定目的。我们提议添加PPT是因为：失眠与高伴侣有关；针灸会导致从交感神经到副交感神经的转变。这将为我们提供一种潜在有用的机制，以说明针灸对失眠和可能其他情况的临床益处。鉴于失眠患者白天症状的突出性，我们的研究将通过将PPT纳入实验室环境来加强。 公共卫生相关性：失眠是与精神病和医学合并症有关的常见且残疾的疾病，尽管目前可用的治疗方法经常持续存在。据报道，针灸可以使失眠的个体受益，并可以减少高音。该盲人RCT将研究标准化针灸方案对失眠，白天症状和高音的影响。